Thalassaemia International Federation (TIF) has published the 4th Edition 2021 Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT) in collaboration with editors Cappellini MD., Farmakis D., Porter J., and Taher A.  The TIF Guidelines are adopted and used extensively by academics, researchers and healthcare professionals all over the world as the only evidence-based reference text concerning the treatment of patients with TDT. The newly launched edition includes brand new chapters on the recently approved modalities of patient treatment, the value of patient engagement at the decision-making level, the Reference Centres’ contribution to patient care, and much more. You can access the publication here.