Clinical Trials

Title Sponsor Keywords Start Date Completion Date
A Long-term Follow-up Study in Subjects Who Received CTX001Vertex Pharmaceuticals Incorporated1 Feb 20211 Sep 2039
Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease.AstraZenecaTicagrelor, Vaso-Occlusive Crises, Paediatric Patients, 6 Months to <18 Years, Sickle Cell Disease, Sickle Cell Anemia, Platelet aggregation, Brillinta, Acute Chest Syndrome, painful crisis30 Jun 202010 Oct 2022
RHD Genotype Matching for Anti-DChildren's Hospital of PhiladelphiaChronic Transfusion1 Jun 20201 Jul 2024
Thalassemic Iron Overload Cardiomyopathy is Ameliorated by Taurine SupplementationUniversity Health Network, Toronto1 Jun 202031 May 2023
Prevalence of Osteoporosis in Sickle Cell DiseaseHospices Civils de Lyonsickle cell disease1 Jun 20201 Dec 2021
A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCDUniversity of Regensburg1 Apr 202031 Mar 2027
Dermatological Abnormalities in Beta-thalassemia MajorAssiut University2 Mar 20202 Apr 2021
SMYLS: A Self-management Program for Youth Living With Sickle Cell DiseaseMedical University of South Carolina2 Mar 202031 Dec 2020
β-globin Restored Autologous HSC in β-thalassemia Major PatientsShanghai Bioray Laboratory Inc.1 Mar 20201 Mar 2022
Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem CellsShanghai Bioray Laboratory Inc.1 Mar 20201 Jan 2022
Links Between Cognitive Functions and Clinical, Biological and Neuroradiological Outcomes in Adults With Sickle Cell Disease.Hospices Civils de LyonSickle Cell Disease, Drepanocytosis1 Mar 20201 Sep 2022
Safety of Single Ascending Doses of CSL889 in Adult Patients With Stable Sickle Cell DiseaseCSL Behring1 Mar 20201 Mar 2021
Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients (THALA-RAP)Università degli Studi di Ferrararapamycin, erythroid differentiation, γ-globin, fetal haemoglobin28 Feb 202030 May 2021
Effect of Exercise on Biomarkers in SCTSt. Louis UniversitySickle Cell Trait17 Feb 202014 May 2021
A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Diseasebluebird bio14 Feb 20201 Nov 2023
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell DiseaseEpiDestiny, Inc.3 Feb 20203 Mar 2021
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell DiseaseGlobal Blood TherapeuticsSickle Cell Disease, Transcranial Doppler Ultrasound (TCD)1 Feb 20201 Mar 2026
High-flow Oxygen for Vaso-occlusive Pain CrisisAssistance Publique - Hôpitaux de ParisSickle Cell Disease, vaso-occlusive pain crisis, HFNO, ACS1 Feb 202029 May 2021
RH Genotype Matched RBC TransfusionsChildren's Hospital of PhiladelphiaChronic Transfusion1 Feb 20201 Jul 2024
Dissemination and Implementation of Stroke Prevention Looking at the Care EnvironmentUniversity of Alabama at Birmingham1 Feb 20201 Jun 2022
Daily Vitamin D for Sickle-cell Respiratory ComplicationsGary M Brittenham, MDSickle Cell Disease, Acute Chest Syndrome, Respiratory Complication, Vitamin D Deficiency1 Feb 20201 Dec 2024
Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS TMPRSS6-LRxIonis Pharmaceuticals, Inc.Thalassaemia, Beta Thalassemia, IONIS TMPRSS6-LRx1 Feb 20201 Oct 2022
Acupuncture for Adults With Sickle Cell Disease (SCD): A Feasibility StudyUniversity of Illinois at Chicagosickle cell disease, pain, chronic pain, acupuncture15 Jan 202015 Apr 2020
Qualitative Survey of Potential Exercise Activity in Adults With Sickle Cell Anemia (SCA)University of Alabama at Birmingham15 Jan 202015 Jan 2021
FOCUS for Pediatric Sickle Cell Disease and CancerGeorgia State UniversityPediatric cancer, Pediatric Sickle Cell Disease, Quality of Life, Randomized Controlled Trial, Intervention, Photography, Narrative Psychology, Adolescence10 Jan 202030 Jul 2020
Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCDGlobal Blood TherapeuticsSickle Cell Disease, SCD9 Jan 20201 Dec 2021
Folic Acid Supplementation in Children With Sickle Cell DiseaseUniversity of British ColumbiaFolic Acid, Unmetabolized Folic Acid, Pediatrics3 Jan 20201 Jan 2022
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)Mark Gladwin1 Jan 202030 Apr 2026
Ketamine Infusion for Sickle Cell Pain CrisisDuke UniversityKetamine, Intravenous Infusions, Anemia; Sickle-Cell, with Crisis, Acute Pain1 Jan 202031 Aug 2020
Thrombophilia In Beta ThalassemiaAssiut University1 Jan 20201 Jan 2021
Is the Preoperative Preparation of Sickle Cell Patients Optimal: Assessment of Practices and Post-operative ComplicationsQueen Fabiola Children's University Hospital1 Jan 202030 Jun 2020
Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia PatientsAl-Neelain Universitysickle cell anemia, Gum Arabic, Fetal Hemoglobin15 Dec 201915 Jul 2020
Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell DiseaseNovartis PharmaceuticalsSEG101, SCD, Crizanlizumab, Sickle cell nephropathy, chronic kidney disease, CKD, albuminuria (ACR), renal function, standard of care10 Dec 201917 Sep 2022
Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell DiseaseUniversity of Chicago1 Dec 20191 Nov 2027
A Study to Assess the Safety and Pharmacokinetics of HBI-002, an Oral Carbon Monoxide Therapeutic, in Healthy VolunteersHillhurst Biopharmaceuticals, Inc.Anemia, Sickle Cell, Anemia, Hemolytic, Congenital, Anemia, Hemolytic, Anemia, Hematologic Diseases, Hemoglobinopathies, Genetic Diseases, Inborn, Carbon Monoxide, CO, Heme Oxygenase, HO-11 Dec 20191 May 2020
DREPAMASSE Study - Evaluation of a Newborn Screening for Sickle Cell Disease by Tandem Mass SpectrometryHospices Civils de Lyon1 Dec 20191 Dec 2020
Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating TherapyWeill Medical College of Cornell UniversityQuantitative Susceptibility Mapping, Iron chelating therapy, Iron overload, Liver iron concentration, erythrocyte transfusion, liver transplantation, magnetic resonance imaging, thalassemia major1 Dec 201931 Jan 2024
Phase 2a Pilot Study of NBMI Treatment in Patients With Beta Thalassemia Major, Requiring Iron ChelationEmeraMed21 Nov 201930 Jun 2020
Pediatric Open-Label Extension of VoxelotorGlobal Blood Therapeutics18 Nov 20191 Jan 2026
Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE)Assistance Publique - Hôpitaux de Paris15 Nov 201915 Nov 2024
Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea UtilizationSt. Jude Children's Research Hospitalimplementation science, sickle cell anemia, digital medicine, adherence, hydroxycarbamide, health innovation11 Nov 20191 Jun 2022
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Subjects Who Require Regular RBC Transfusions Due to Beta (β)-Thalassemia.CelgeneACE-536, Luspatercept, Pharmacokinetics, Beta-Thalassemia, Red Blood Cell Transfusion7 Nov 20192 Sep 2026
iPeer2Peer Program for Youth With Sickle Cell DiseaseThe Hospital for Sick Children1 Nov 20191 May 2020
Intranasal Ketamine For Pain Control In Patients With Sickle Cell Disease And Vaso-occlusive Episode (VOE) In The PEDAbigail Nixon1 Nov 20191 Jan 2021
Algorithm for Apherisis Monitoring and Prescription Assistance in Sickle Cell Patients (ALGODREP)Etablissement Français du SangAlgorithm, Apherisis, Sickle cell patients1 Nov 20191 Nov 2021
Cystatin c and Beta 2 Microglobulin in Thalassemic Children.Assiut Universityrenal impairment1 Nov 20191 Mar 2021
Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major ThalassemiaBeni-Suef Universitythymoquinone, omega3, hydroxyurea, pediatric Thalassemia Major, oxidative stress, iron chelation, iron overload, chelation activity of thymoquinone, antioxidant effect of omega3, anti-hemolysis effect of hydroxyurea1 Nov 20191 Nov 2020
Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell AnemiaBeni-Suef Universityomega3, Vaso-occlusive painful crisis, Pediatric sickle cell anemia, comparative effective analysis in VOC, Anti-inflammatory effect of Vit-D, Anti-hemolytic effect of Vit-D, Anti-hyperlipidemia of Vit-D, effect of omega-3 on blood rheology, effect of omega-3 on blood viscosity, Antiaggregation effect of omega-3, Anti-inflammatory effect of statins, Anti-inflammatory effect of zinc supplements, effect of zinc supplements on blood viscosity, effect of zinc supplements on blood rheology, Antiaggregation effect of zinc supplements, pediatric sickle cell disease1 Nov 20191 Nov 2020
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic ConditionsDuke University29 Oct 201929 Feb 2024
A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell DiseaseBoston Children’s HospitalSickle Cell, MRI, Near Infrared Spectroscopy (NIRS)25 Oct 20191 Aug 2020
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism LevelsNational Heart, Lung, and Blood Institute (NHLBI)Graft-Versus-Host Disease, Donor Apheresis, Host-Donor Chimerism24 Oct 20191 Jan 2030
A Study of SHP655 (rADAMTS13) in Sickle Cell DiseaseShire21 Oct 201927 Aug 2021
Cerebral Oxygen Metabolism in ChildrenWashington University School of Medicineextracorporeal membrane oxygenation17 Oct 20191 Dec 2027
A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related PriapismNovartis PharmaceuticalsPriapism, sickle cell disease, crizanlizumab, P-selectin, SEG101, monoclonal antibody, prolonged erection, painful erection16 Oct 20194 Mar 2022
Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced Intensity Conditioning Regimen With Standard of Care in Adolescents and Adults With Severe Sickle Cell DiseaseAssistance Publique - Hôpitaux de Paris15 Oct 201915 Oct 2024
CSL200 Gene Therapy in Adults With Severe Sickle Cell DiseaseCSL Behring2 Oct 20191 Jul 2021
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell AnemiaUniversity of PittsburghBasal platelet activation, MitoQ, mitochondrial ROS (Reactive Oxygen Species)1 Oct 201931 Dec 2020
The Impact of Oxidative Stress on Erythrocyte BilogyVersiti1 Oct 20191 Oct 2023
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell DepletionMitchell Cairoallogeneic stem cell transplantation, t-cell depletion, alpha beta cell depletion1 Oct 201931 Dec 2024
Collection of Human Biospecimens for Basic and Clinical Research Into Alpha Globin VariantsNational Institute of Allergy and Infectious Diseases (NIAID)Assay Development, Malaria, Sickle Cell Disease, Alpha Thalassemia25 Sep 201931 Jul 2028
To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell DiseaseAxcella Health, IncAmino Acid, Food Study25 Sep 20191 Oct 2020
Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive TroponinDr. med. Mahir KarakasAspirin, Atorvastatin, Troponin1 Sep 20191 Apr 2022
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant TransplantEmory UniversityPediatrics, Non-malignant hematologic diseases, Severe aplastic anemia, Fanconi anemia, Sickle cell disease, Hematopoietic stem cell transplantation, Thalassemia, Mismatched unrelated donor22 Aug 20191 Dec 2023
Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124Silence Therapeutics plc20 Aug 201914 Oct 2021
A Study to Evaluate Long-term Safety in Subjects Who Have Participated in Other Luspatercept (ACE-536) Clinical TrialsCelgeneACE-536, Luspatercept, MDS, Beta-thalassemia, Myeloproliferative neoplasm (MPN)-associated myelofibrosis12 Aug 201924 Jan 2028
Comparing Individualized vs. Weight Based Protocols to Treat VOE in SCD Occlusive Episodes in Sickle Cell DiseaseDuke University6 Aug 20197 Jan 2022
Deferoxamine for Sickle Cell Chronic Leg Ulcer TreatmentTauTona Groupchronic sickle cell leg ulcer1 Aug 20191 Apr 2021
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease PatientsNovartis PharmaceuticalsSickle Cell Disease, SEG101, Crizanlizumab, Hydroxyurea/ Hydroxycarbamide Therapy, Vaso-Occlusive Crises, SCA, blood disorders, hemoglobin, red blood cells, sickle-like shape, mutation in hemoglobin gene, sickle-cell trait, sickle-cell crisis26 Jul 20196 Dec 2027
Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell DiseaseYale University26 Jul 201931 Dec 2020
Hydroxyurea Exposure Limiting Pregnancy and Follow-Up LactationChildren's Hospital Medical Center, CincinnatiHydroxyurea22 Jul 20191 Jul 2022
Neuropathic Pain in Jamaicans With Sickle Cell DiseaseThe University of The West IndiesQuantitative sensory testing, Jamaica15 Jul 20191 Jul 2020
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects With Stable Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)HbS polymerization, pyruvate kinase, 2,3- diphosphoglycerate, ATP in red blood cells, acute sickle pain11 Jul 201931 Dec 2020
Sickle Cell Pain: Intervention With Capsaicin ExposureChildren's Hospital of MichiganCapsaicin, Topical Analgesia, Quantitative Sensory Testing, Pain3 Jul 201930 Jun 2020
Screening for Hemoglobinopathies in Pregnant WomenUniversity Hospital, Basel, Switzerlandthalassemia, sickle cell anaemia, molecular genetic analysis3 Jul 20191 Jul 2020
Sickle Cell Uric Acid (SCUA) - Cohort RepositoryVirginia Commonwealth UniversityUric acid1 Jul 20191 Oct 2024
Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent PatientsRare Partners srl Impresa SocialeFetal hemoglobin, Sirolimus, Red Blood Cells27 Jun 201930 Sep 2020
Near Infrared Spectroscopy in Sickle Cell Pediatric PatientsChildren's Research Institute26 Jun 201930 Jun 2022
Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic TransplantationCenter for International Blood and Marrow Transplant Research14 Jun 20191 Mar 2025
A Program to Increase Sickle Cell Trait Knowledge Among Parent of Infants Identified in Newborn ScreeningNationwide Children's HospitalSickle Cell Trait, Education13 Jun 201931 Dec 2021
Hydroxyurea Therapy: Optimizing Access in Pediatric Populations EverywhereSt. Jude Children's Research Hospital10 Jun 201930 Jun 2020
The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia MajorBeni-Suef University3 Jun 201930 Dec 2019
Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical StudyFirst Affiliated Hospital of Guangxi Medical Universitythalassemia major, hematopoietic stem cell transplantation1 Jun 201931 May 2023
Red Cell Distribution Width Index Versus Red Cell Distribution Width as Discriminating Guide for Iron Deficiency Anaemia and Beta Thalassemia Trait .Assiut University1 Jun 20191 Jun 2022
SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial)ADDMEDICA SASAalbuminuria, hydroxycarbamide28 May 20191 Jun 2021
Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle NephropathyNational Heart, Lung, and Blood Institute (NHLBI)Sickle Nephropathy, Iothalamate, Cystatin-C24 May 20191 May 2021
An Extension Study of IMR-687 in Adult Patients With Sickle Cell AnemiaImara, Inc.22 May 20191 Jun 2024
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific ProductsChildren's Hospital of Philadelphia15 May 201931 Dec 2020
Safety Study for Beta Thalassemia Subjects on PTG-300Protagonist TherapeuticsChronic anemia, β-thalassemia10 May 201910 May 2023
Expanded Access to Voxelotor for Patients With Sickle Cell Disease Who Have No Alternative Treatment OptionsGlobal Blood Therapeutics9 May 201919 Dec 2019
TAPS2 Transfusion Antenatally in Pregnant Women With SCDGuy's and St Thomas' NHS Foundation Trustpregnancy, exchange transfusion, perinatal complications2 May 20191 May 2021
Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome. A Bi-centric, Open, Parallel-group, Randomized Controlled StudyAssistance Publique - Hôpitaux de ParisAcute chest syndrome, SCD, PCR multiplex, antibiotic treatment1 May 20191 Jun 2020
Choroidal Thickness in Beta-thalassemia PatientsUniversity Hospital of Patrasbeta-thalassemia, choroidal thickness, enhanced depth imaging, optical coherence tomography1 May 20191 Sep 2019
SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare AnemiasAbfero Pharmaceuticals, Incchelator1 May 20191 Jan 2022
Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)Children's Hospital Medical Center, CincinnatiSickle Celll Anemia, Transcranial Doppler, Tanzania, Hydroxyurea, Stroke24 Apr 201931 Mar 2022
Sexual Maturation in β-Thalassemia Major Patients in Assiut University HospitalAssiut University15 Apr 201915 Apr 2020
Pulmonary Ultrasound in the Diagnosis of Acute Thoracic Syndrome in Vaso-occlusive Sickle Cell CrisisCentre Hospitalier Intercommunal Creteil4 Apr 20191 Aug 2020
Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia MajorNational Taiwan University Hospital1 Apr 20191 Apr 2020
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell TransplantationEmory UniversityPediatrics, Hematopoietic stem cell transplantation, HLA matched sibling22 Mar 20191 Jan 2027
Apotransferrin in Patients With β-thalassemiaSanquin Plasma Products BV21 Mar 20191 May 2021
Role of Ajwa Derived Polyphenols in DyslipidaemiasAga Khan UniversityAjwa (Pheonix Dactylfera) Derived polyphenol, Dyslipidemia, Cardioprotection, HDL, Transferulic Acid, Gallic Acid20 Mar 20197 Dec 2019
Collect of Cord Blood From Subjects at Risk for Sickle Cell Disease, for the Purpose of Laboratory ResearchInstitut National de la Santé Et de la Recherche Médicale, France1 Mar 20191 Mar 2022
Detection Of β-thalassemia Carriers In AssiutAssiut UniversityHbA2, HPLC1 Mar 20191 Jun 2021
Resistance Exercise on Postprandial Hyperglycemia in Patients With B-thalassemia Exhibiting Resistance to InsulinUniversity of Thessaly11 Feb 201930 Oct 2019
Whole Exome Sequencing and Whole Genome Sequencing for Non-immune Fetal/Neonatal HydropsThomas Jefferson Universityhydrops, prenatal diagnosis, amniocentesis, whole genome sequencing15 Jan 20191 Dec 2021
Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic AnemiaProtagonist Therapeuticschronic anemia, β-thalassemia19 Dec 20181 Dec 2020
A SAD/MAD to Assess the Safety, Pharmacokinetics and Pharmacodynamics of FT-4202 in Healthy Volunteers and Sickle Cell Disease PatientsForma Therapeutics, Inc.11 Dec 20181 Sep 2020
Short-term Clinical Study of CN128 in Thalassemia PatientsHangzhou Zede Pharma-Tech Co., Ltd.3 Dec 201817 Dec 2019
Outcomes Mandate National Integration With Cannabis as MedicineOMNI Medical Services, LLC1 Dec 201831 Dec 2025
Impact on the Length of Stay in Incentive Spirometry and Pain in the Decompensation of Sickle Cell Disease: .Centre Hospitalier Régional d'OrléansSickle cell disease, incentive spirometry, pain, children6 Nov 20186 Apr 2019
Community Health Workers and mHealth for Sickle Cell Disease CareChildren's Hospital of PhiladelphiaSickle Cell Disease1 Nov 201830 Nov 2022
Acupuncture for Pain in Sickle Cell DiseaseDeepika DarbariPain, Acupuncture23 Oct 201823 Oct 2026
Study of a Red Blood Cell Deformability Parameter in Patients With Sickle Cell DiseaseAssistance Publique Hopitaux De Marseille14 Sep 201814 Sep 2021
Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease PatientsNovartis PharmaceuticalsSEG101, Sickle cell disease, crizanlizumab, pediatric, pharmacokinetic, P-selectin30 Aug 201831 Mar 2022
Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal DemiseMedical College of WisconsinFetal Magnetocardiography, Stillbirth, Intrauterine Fetal Demise, Mobile Medical Technologies, Fetal Heart Rate Variability, Fetal Arrhythmias, High Risk Pregnancy, Pregnancy, Fetal Anomaly, Fetal Echocardiography, Non-Stress Testing, New Technology, Birth Defects, Fetal Research1 Jul 201830 Apr 2022
Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic PatientsUniversità degli Studi di FerraraPacked RBCs, leukodepletion, buffy-coat, transfusion14 May 20181 Jun 2019
Vitamin D Supplementation in Children With Sickle Cell DiseaseSt. Justine's HospitalBolus supplementation, Pilot randomised controlled trial, Vitamin D1 May 201831 Jul 2019
Hydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy TrialColumbia UniversityHydroxyurea, Community health worker (CHW), Text messages, Medication adherence1 May 20181 Jun 2021
Complications in Children With B- Thalassemia MajorAssiut University1 May 20181 Oct 2019
Fetal Birth Defects: Toward a Precision-based ApproachUniversity of California, San Franciscohydrops fetalis, birth defect, fetal anomaly, whole exome sequencing1 Apr 20181 Dec 2025
Immunomodulatory Vitamin D in ThalassemiaUniversitas Padjadjaran1 Apr 201815 Aug 2018
Hemoglobin Desaturation in Sickle Cell DiseaseUniversity Hospitals Cleveland Medical Center23 Mar 20181 Dec 2022
Hyperbaric Oxygen Therapy in Sickle Cell PainUniversity of Nebraska1 Mar 20181 Mar 2019
A Study to Assess the Safety, Tolerability, and Efficacy of ST-400 for Treatment of Transfusion-Dependent Beta-thalassemia (TDT)Sangamo TherapeuticsBeta thalassemia, Beta-thalassemia, Thalassemia major, Cooley's anemia, ZFN mediated genome editing, zinc finger nuclease1 Mar 20181 May 2022
Shared-Decision Making for HydroxyureaChildren's Hospital Medical Center, Cincinnatishared decision making, parent-provider communication, hydroxyurea, sickle cell disease1 Mar 201830 Nov 2020
Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell TransplantUniversity of Michiganbone marrow cellularity, bone marrow transplant1 Mar 20181 Mar 2023
Stem Cell Transplant in Patients With Severe Sickle Cell DiseaseKathleen Dorritie15 Feb 201815 Feb 2023
Risk Factors for Allo-immunization in Sickle Cell DiseaseHanane EL KENZSickle cell disease, Allo-immunization1 Feb 20181 Dec 2018
Transfusion in Sickle Cell Disease: Risk Factors for AlloimmunizationHanane EL KENZSickle cell disease, Allo-immunization, Blood transfusion1 Feb 20181 Jan 2020
Transfusion in Sickle Cell Disease: Screening of Sickle Cell Disease Trait in Blood DonorsHanane EL KENZSickle cell, Heterozygous, Blood donor1 Feb 20181 Jan 2020
Predictors and Outcomes in Patients With Sickle Cell DiseaseSt. Jude Children's Research HospitalHealth Care Transition, Adolescent, Young Adult1 Feb 20181 Feb 2022
HRV-B for Symptom Management in Sickle Cell PatientsGreenville Health SystemHeart Rate Variability Biofeedback22 Jan 20181 Oct 2018
Defibrotide in Sickle Cell Disease-Related Acute Chest SyndromeNew York Medical College12 Jan 20181 Jan 2022
Autonomic Nervous System and Sickle Cell DiseaseAssistance Publique - Hôpitaux de Parissickle cell disease; asthma; beta-agonist; hear rate variability5 Jan 201831 May 2019
iCanCope With Sickle Cell PainSeattle Children's Hospital1 Jan 20181 Dec 2022
A Phase - IIa - IIb, Open Label Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCDHaEmek Medical Center, Israel1 Jan 201830 Jun 2020
Efficacy and Safety of RBCs Derived From Mirasol-treated Whole Blood in Patients Requiring Chronic Transfusion (PRAISE)Terumo BCTbioThalassemia, pathogen reduction therapy1 Jan 20181 Jun 2020
A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-ThalassemiaCelgene(β)-Thalassemia, Beta-Thalassemia, Phase 2, Luspatercept, ACE-536, Safety, Efficacy, Placebo, Red Blood Cell Transfusions, Erythrocyte transfusion, Hb increase, NTDT1 Jan 20181 Feb 2020
A Study of IMR-687 in Adult Patients With Sickle Cell Anaemia (Homozygous HbSS or Sickle-β0 Thalassemia)Imara, Inc.1 Jan 20181 Jun 2019
Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)Duke University1 Jan 20181 Jul 2018
Ketamine for Acute Painful Crisis in Sickle Cell Disease PatientsDammam University1 Jan 201827 Feb 2019
A Study of the Effect of IW-1701, a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)Ironwood Pharmaceuticals, Inc.Sickle Cell Disease, SCD1 Dec 20171 Jul 2019
Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell DiseaseSt. Jude Children's Research HospitalVirtual reality, Pain, Nonpharmacological1 Dec 20171 Dec 2020
Quality of Life and Treatment Satisfaction in β-Thalassemia Patients Receiving DeferasiroxAssiut University1 Dec 20171 Mar 2020
Study on the Mechanism of Colla Corri Asini in the Treatment of Thalassemia Patients With Pregnancy AnemiaThe First Affiliated Hospital, Guangzhou University of Traditional Chinese MedicineThalassemia, Pregnancy, Globin expression, Colla corii asini1 Dec 201728 Feb 2019
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood CancerRoswell Park Cancer Institute20 Nov 20176 Sep 2022
Non-Myeloablative Conditioning Regimen With Haploidentical T-Cell-Depleted Peripheral Blood Transplant for Patients With Severe Sickle Cell DiseaseCity of Hope Medical CenterSickle Cell Disease, Sickle Cell Disorders, Hemoglobinopathies, Thalassemia, Anemia, Sickle Cell, Haploidentical Transplant, Nonmyeloablative Conditioning, CD4+ T cell, CD4+ T cell-depleted Hematopoietic Cell Transplant, Mixed Chimerism1 Nov 20171 Nov 2021
Re-Aiming at Hydroxyurea Adherence for Sickle Cell With mHealthSt. Jude Children's Research HospitalmHealth, Medication adherence, Barriers to adherence1 Nov 20171 Nov 2021
A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent Beta-ThalassemiaHoffmann-La Roche30 Oct 20171 May 2018
Sickle Cell Disease: Targeting Alloantibody Formation Reduction; Risk Factors, and GeneticsSanquin Research & Blood Bank Divisions8 Oct 201731 Dec 2019
Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)Duke University1 Oct 20171 Oct 2019
Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell DiseaseCity of Hope Medical CenterSickle Cell Disease, Hematopoietic stem cell transplantation, Haploidentical stem cell transplantation, Post-transplant Cytoxan1 Oct 20171 Aug 2022
Gene Transfer for Sickle Cell DiseaseDavid WilliamsGene therapy, lentivirus vector, BCL11A, Fetal Hemoglobin1 Oct 20171 Oct 2024
Hyalornic Acid Level in β-Thalassemic Children Treated for Hepatitis C VirusTanta University1 Oct 20171 Mar 2019
Muscle Function and Its Biological and Physiological Determinants in Sickle Cell DiseaseHospices Civils de LyonSickle Cell Disease, Muscle function, Hemorheological disorders30 Sep 201730 Sep 2019
Sickle Cell Trait and Exercise, Effect of Hot EnvironmentUniversity of the French West Indies and French GuianaExercise, sickling, rhamdomyolysis, oxidative stress25 Sep 20171 Jul 2019
Gene Therapy for Beta-Thalassemia Major Using Autologous Hematopoietic Stem Cell Genetically ModifiedNanfang Hospital of Southern Medical UniversityBeta thalassemia, Gene therapy, Beta-globin, Hematopoietic stem cells, Lentiviral vector15 Sep 201715 Sep 2021
iCanCope With Sickle Cell Disease: a Computerized Cognitive Behavioral Therapy Program for Pain ManagementUniversity of Pittsburgh1 Sep 20171 Sep 2019
Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia PatientsAsmaa Nady Hussein1 Sep 20171 Mar 2020
HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell DiseaseCentre Hospitalier Intercommunal Creteilsickle cell disease, haploidentical, graft, marrow1 Sep 20171 Sep 2020
sPLA2 in EBC During Acute Chest SyndromeVirginia Commonwealth Universityacute chest syndrome, secretory phospholipases A2, exhaled breath condensate, sickle cell disease1 Sep 201728 Feb 2018
Haploidentical Bone Marrow Transplantation in Sickle Cell PatientsMedical College of WisconsinReduced Intensity Conditioning, Haploidentical, Bone Marrow, Transplant, Sickle Cell Disease1 Sep 20171 Dec 2024
Kidney Function in Sickle Cell AnemiaUniversity of North Carolina, Chapel Hill1 Sep 201731 Aug 2022
Mesenchymal Stromal Cells for Haplo Hematopoietic Cell Transplantation for Sickle Cell DiseaseEmory UniversityHematopoietic cell transplantation (HCT), Haploidentical, Mesenchymal stromal cells1 Sep 20171 Sep 2021
The Implementation of the Automated Erythrocytapheresis in Egyptian Sickle Cell Disease CenterAin Shams University16 Aug 20171 Jan 2020
A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCTPhoenix Children's Hospital1 Aug 20171 Oct 2018
Zinc Supplementation in Patients With β-Thalassemia Major Complicated With Diabetes MellitusAin Shams UniversityZinc, blood glucose, diabetes, beta thalassemia1 Aug 201728 Aug 2018
Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) PatientsNational Heart, Lung, and Blood Institute (NHLBI)Plerixafor, Leukapheresis, Mobilization, Stem Cells, Sickle Cell Disease25 Jul 201728 Feb 2027
Sickle Cell Disease, HemechipUniversity Hospitals Cleveland Medical Center11 Jul 201730 May 2022
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling DonorUniversity of Calgarysickle cell disease, stem cell transplant, red blood cell engraftment, nonmyeloablative, pure red cell aplasia5 Jul 20171 Jul 2023
Laboratory-based Hypnosis Intervention on Pain Responsivity in Adolescents With Sickle Cell Disease and Healthy ControlsUniversity of California, Los AngelesAdolescence, Autonomic Nervous System, Hypnosis, Pain, Sickle Cell Disease1 Jul 20171 Jun 2020
BEATS 2: Music Therapy in Sickle CellUniversity Hospitals Cleveland Medical Center26 Jun 201731 Dec 2018
An Open Label Randomized Controlled Trial to Evaluate the Efficacy and Safety of HYDROXYUREA in Management of Beta Thalassemia Patients in Karachi PakistanDr.Saqib Hussain Ansari13 Jun 201730 Jan 2018
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Healthy VolunteersIonis Pharmaceuticals, Inc.Thalassaemia, IONIS TMPRSS6-Lrx6 Jun 201731 Mar 2018
Erythrocyte Glutamine/Glutamate Ratio Relation to Pulmonary Hypertension Risk in Thalassemic ChildrenAssiut UniversityThalassemia, Glutamine/glutamate ratio, Pulmonary hypertension1 Jun 20171 Jun 2018
Sleep and Pain in Sickle Cell DiseaseJohns Hopkins University1 Jun 201730 May 2021
Evaluation of Nutritional Status in Thalassemia Major Patients in Assiut Children HospitalAssiut Universitythalassemia - nutrition -growth1 Jun 20171 Dec 2018
Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical CareNational Human Genome Research Institute (NHGRI)CRISPR, Gene Editing, Qualitative, Participation Clinical Trials, Genetic Literacy1 Jun 201730 Jun 2018
A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Subjects With Transfusion-Dependent β-Thalassemia, Who Have a β0/β0 Genotypebluebird bio1 Jun 20171 Apr 2021
A Study to Compare if the Uptake of Ticagrelor in the Body Differs When Different Tablets Are Administered.AstraZenecaAbnormal hemoglobin (called hemoglobin S or sickle hemoglobin) in the red blood cells, Thrombotic cardiovascular events, Acute coronary syndrome, P2Y12 platelet inhibitor, Brilinta4 May 20173 Jul 2017
The Effective and Safety of Thalidomide in TIXiao-Lin YinThalidomide TI2 May 20172 May 2019
A Study to Evaluate Safety, Pharmacokinetic, and Biological Activity of INCB059872 in Subjects With Sickle Cell DiseaseIncyte CorporationSickle cell disease (SCD), sickle cell SS, lysine demethylase 1 (LSD1) inhibition1 May 20171 Jun 2017
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell DiseaseUniversity of Illinois at Chicago28 Apr 201728 Oct 2026
Precision Exercise in Children With Malignant HemopathiesUniversity of Milano Bicoccaexercise, children, adolescent, cancer, malignant hemopathies, leukemia, lymphoma, hematopoietic stem cell transplant, survivor, oxidative metabolism, strength, balance, flexibility, quality of life3 Apr 20173 Apr 2022
Denosumab Versus Zoledronic Acid in Thalassemia-Induced OsteoporosisHamad Medical CorporationOsteoporosis, Beta-Thalassemia Major, Denosumab, Zoledronic Acid1 Apr 20171 Apr 2018
EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine TransfusionsSanquin-LUMC J.J van Rood Center for Clinical Transfusion ResearchHemolytic disease of the fetus and newborn, HDFN, Red blood cell alloimmunization1 Apr 20171 Aug 2020
Evaluation of Knowledge Among Adolescents With Sickle Cell Disease.Adele CARLIER-GONOD10 Mar 20171 Mar 2018
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)Peripheral Blood Stem Cells, Host-Donor Chimerism, Graft Versus Host Disease, Haploidentical, Donor Apheresis8 Mar 201731 Aug 2026
Sofosbuvir/Ledipasvir for Hepatitis C Genotype 1-6 in Patients With Transfusion-Dependent Thalassemia: An Open Label TrialAla'a ShararaThalassemia, HCV, Sofosbuvir, Ledipasvir15 Feb 201715 Aug 2017
In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)University of California, San Franciscointrauterine transfusion, in utero human stem cell transplantation1 Feb 20171 Feb 2024
Hydroxyurea Management in Kids: Intensive Versus Stable Dosage StrategiesSt. Jude Children's Research HospitalSickle cell, Hydroxyurea, Infants1 Feb 20171 Jun 2020
New Hemolysis Parameters in Sickle Cell DiseaseQueen Fabiola Children's University Hospital1 Feb 201727 Feb 2019
Pathophysiology of Acute Pain in Patients With Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)Pain, Cell Free DNA, Inflammatory Markers, Microparticles, NETosis31 Jan 201731 Oct 2021
Gaming Technology to Engage Adolescent Sickle Cell Patients in Pain ManagementKlein Buendel, Inc.Sickle Cell Disease, Adolescence, Pain Assessment, Tablet Application, Pain, mHealth15 Jan 201730 Sep 2017
Omega-3 Fatty Acids in Sickle Cell DiseaseRobin E. MillerSickle Cell Disease, omega-3 fatty acids, Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid (EPA)1 Jan 20171 Apr 2019
Dose-Finding Study of SC411 in Children With Sickle Cell DiseaseSancilio and Company, Inc.1 Jan 20171 Jul 2017
A Pilot Study of Fecal Microbiome and Neutrophil Cellular Adhesion Molecules in Patients With Sickle Cell Disease (SCD)Rhode Island Hospital1 Jan 20171 Dec 2017
A Phase Ib Study of NVX-508 in Sickle Cell DiseaseAmma Owusu-Ansah, MD1 Jan 20171 Dec 2017
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia MajorIndonesia UniversityHaptoglobin, Hemopexin, Hemolysis, Malondialdehyde, Glutathione, Oxidative stress, Alpha-Tocopherol30 Dec 20161 Aug 2017
Sickle-cell Disease Registry of the GPOHUniversity Hospital HeidelbergAnemia, Sickle Cell, Sickle Cell disease15 Dec 201631 Dec 2040
A Study of EPEG in Beta Thalassemia PatientsProlong Pharmaceuticals1 Dec 20161 Jun 2017
Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine TreatmentShanghai First Maternity and Infant Hospital1 Dec 20161 Aug 2018
The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia MajorCairo UniversityBeta Thalassemia, Metformin, Oxidative stress, Iron overload, Liver function1 Dec 20161 May 2018
Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell DiseaseAlessandra BiffiPlerixafor1 Dec 20161 Jan 2018
Study to Evaluate the Effect of GBT440 Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE)Global Blood Therapeutics1 Dec 20161 Jun 2019
Fetal Hemoglobin Induction Treatment MetforminBaylor College of MedicineMetformin, Sickle Cell Anemia, Sickle Cell Disease, Hemoglobinopathies, Hemoglobin Disorder, Blood Disease, Hemoglobin Disease; Sickle-Cell, Thalassemia, Hemoglobin Disease1 Nov 20161 Nov 2022
A Study of IMR-687 in Healthy Adult VolunteersImara, Inc.Sickle Cell Disease, Sickle Beta 0 Thalassemia1 Nov 20161 Jun 2017
SCD-PROMIS: A Software Platform to Enhance Self-efficacy and Patient-provider Engagement for Patients With Sickle Cell PainChildren's Research Institute1 Nov 20161 Sep 2018
Hydoxyurea Exposure in Lactation: A Pharmacokinetics Study (HELPS)Children's Hospital Medical Center, CincinnatiHydroxyurea1 Oct 20161 Nov 2019
Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization.Francis CorazzaSickle Cell Disease, Heme oxidase-1 (HO-1)1 Oct 20161 Oct 2018
Oxygen Therapy and Pregnancy in Sickle Cell DiseaseAssistance Publique - Hôpitaux de Parissickle cell disease, oxygen therapy, pregnancy, pregnancy in sickle cell disease1 Sep 20161 Jun 2021
Mobile-Directly Observed Therapy on Adherence to HydroxyureaMuhimbili University of Health and Allied SciencesSickle cell disease, Hydroxyurea, Adherence, randomized trial, medication possession ratio1 Sep 20161 Aug 2017
Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell DiseaseVanderbilt Universitysickle cell disease, pulmonary complications, reduced FEV1, azithromycin, lung function1 Sep 20161 Oct 2018
The Effective and Safety of Thalidomide in NTDTXiao-Lin YinThalidomide NTDT1 Sep 20161 Mar 2018
Patient-Empowered Mobile Technology in Hospitalized Patients: Technology Resources to Understand Pain Assessment in Patients With Pain (TRU-PAIN)Duke Universityoncology, bone marrow transplant, sickle cell disease1 Aug 20161 Aug 2018
Monitoring of Chimerism After Transplantation in Patients With β Thalassemia Major and the Treatment Strategies for the Reduction of ChimerismFirst Affiliated Hospital of Guangxi Medical Universitythalassemia, transplantation, chimerism, donor ymphocytes1 Aug 201631 Dec 2017
Extended Evaluation of Deferasirox Film-coated Tablet (FCT) FormulationNovartis PharmaceuticalsAnemia., Myelodysplastic Syndrome, Thalassemia, Film coated tablet1 Jul 20161 Sep 2018
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell DiseaseGeorgia Regents University1 Jul 20161 Jul 2018
Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell DiseaseMonica BhatiaSickle Cell Disease, Graft Versus Host Disease, Abatacept, Hematopoietic Stem Cell Transplantation1 Jul 20161 Dec 2017
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary HypertensionTanta University1 Jul 20161 Dec 2023
Transfusion Treatment in Patients With SCDSocietà Italiana Talassemie ed Emoglobinopatie1 Jul 201631 Dec 2020
Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)Medical College of WisconsinSickle Cell Disease, Young Adults, Phase II Trial, Hematopoietic Cell Transplantation (HCT), Human Leukocyte Antigen (HLA)1 Jun 20161 Oct 2022
Benefits of Nigella Sativa in Children With Beta Thalassemia MajorTanta University1 Jun 20161 Aug 2016
Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive CrisisChildren's Hospital & Research Center OaklandKetamine, Sickle Cell Disease, Vaso-Occlusive Crisis1 Jun 20161 Dec 2018
Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle PatientsAin Shams University1 Jun 20161 Jun 2019
Zinc Supplementation in Children With Sickle Cell Disease in Western KenyaLucas Otieno Tina, MD MScChildren, Sickle Cell Disease, Zinc20 May 201619 Jan 2017
Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent TransfusionsDuke University1 May 20161 Jun 2017
SACRED A Prospective Research Study to Reduce Stroke in Children With Sickle Cell AnemiaChildren's Hospital Medical Center, Cincinnati1 May 20161 Oct 2020
HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning RegimenNational Guard Health Affairs1 May 20161 Dec 2019
Identifying Barriers and Strategies to Support Self-efficacy for Medication Adherence With Text MessagingVanderbilt University1 May 20161 May 2017
Study of Hydroxyurea to Treat Sickle Cell DiseaseMersin UniversitySickle cell disease, Hydroxyurea, Compliance1 May 20161 Jul 2016
A Multi-Center Study of Riociguat in Patients With Sickle Cell DiseasesGregory J. Kato, MDSCD, Sickle Cell Disease, Riociguat, Adempas1 Apr 20161 Jun 2019
A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease PatientsProlong Pharmaceuticals1 Apr 20161 Sep 2017
The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENTUniversity of Florida1 Apr 20161 Apr 2018
Transplantation Using Reduced Intensity Approach for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone MarrowEmory Universitybone marrow transplant1 Apr 20161 Dec 2020
Improving Self-Management in Adolescents With Sickle Cell DiseaseChildren's Hospital Medical Center, CincinnatiAnemia, Sickle Cell, Self Care, Adolescent, Young Adult, Disease Management, Behavioral Activation, Peer Communication1 Apr 20161 Apr 2018
Coordinated HEalthcare for Complex KidsUniversity of Illinois at Chicagocare coordination, Children, Young adults, Chronic disease1 Apr 201631 Aug 2018
Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell DiseaseWashington University School of Medicine1 Mar 20161 May 2020
Investigation of the Genetics of Hematologic DiseasesSt. Jude Children's Research HospitalGenetics, Whole genome sequencing, Pediatrics and hematology1 Mar 20161 Aug 2026
Plasma DNA and Vascular Remodelling in Patients With Sickle Cell DiseaseADDMEDICA SASA1 Mar 20161 Sep 2018
Evaluating Thromboelastography (TEG) and ETP in Sickle AdultsGuy's and St Thomas' NHS Foundation Trust1 Mar 20161 Jun 2016
Myeloablative Conditioning and Haplo AlloSCT for Patients With Sickle Cell DiseaseNew York Medical Collegestem cell transplantation, sickle cell disease, haploidentical, defibrotide1 Feb 20161 Dec 2021
Screening for Alpha Thalassemia in Healthy VolunteersNational Heart, Lung, and Blood Institute (NHLBI)Alpha Thalassemia, Double Deletion1 Feb 20161 Dec 2018
A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest SyndromeUniversity of Mississippi Medical Centersickle cell disease, citrulline1 Feb 20161 Dec 2017
Arginine Therapy for Sickle Cell Disease PainEmory UniversityArginine Therapy1 Jan 20161 Aug 2019
SANGUINATE™ in Sickle Cell Disease Associated Leg UlcerProlong PharmaceuticalsLeg Ulcer, LU, SANGUINATE, QOL, SCD, Sickle Cell Disease, Sickle Cell, Anemia, Leg Wound, Leg, Skin Lesion1 Jan 20161 Jan 2017
Multi-center Study of SC411 for Sickle Cell DiseaseSancilio and Company, Inc.hemoglobin SS, hemoglobin SC, hemoglobin S/β°-thalassemia1 Jan 20161 Dec 2017
Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell DiseaseMontefiore Medical Center1 Jan 20161 Jun 2018
Measures of Respiratory Health (MRH)The Hospital for Sick ChildrenCF, Multiple Breath Washout, Lung Clearance Index, Pediatrics1 Jan 20161 Dec 2018
Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE)Baylor College of Medicine1 Dec 20151 Dec 2020
Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis CTanta University1 Dec 20151 Dec 2016
Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis CTanta University1 Dec 20151 Dec 2016
The Prevalence and Severity of HCV Infection in Thalassemia Major and Thalassemia Intermedia in Siriraj HospitalMahidol UniversityTransient elastography, Fibrotest1 Nov 20151 Feb 2017
Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain CrisesCameroon Baptist Convention HealthKetamine, Intranasal, Pain crisis, Vasoocclusive Pain, Sickle cell disease1 Oct 20151 Feb 2017
the Potential Immunomodulatory Effects of Spirulina on Thalassemic ChildrenTanta University1 Oct 20151 Oct 2017
Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH)ADDMEDICA SASAPharmacokinetics of Hydroxyurea1 Sep 20151 Jun 2016
Prevention of Vaso-occlusive Painful Crisis by Using Omega-3 Fatty Acid SupplementsSultan Qaboos UniversityPrevention of Vaso Occlusive Painful Crisis1 Sep 20151 Mar 2019
Evaluation of the Hemostatic Potential in Sickle Cell Disease PatientsBrugmann University HospitalHemostatic potential, Sickle cell disease, Thrombin generation test1 Sep 20151 Sep 2017
A Single-Dose Relative Bioavailability Study Of GBT440 300 mg Capsules in Healthy SubjectsGlobal Blood Therapeutics1 Sep 20151 Feb 2016
Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy SubjectsGlobal Blood Therapeuticsanemia, sickle cell1 Sep 20151 Feb 2016
Nonpharmacological Approaches and Parental Education in Children With Sickle Cell DiseaseAkdeniz Universitysickle cell disease, nonpharmacological approaches, pain, parent, nurse1 Sep 20152 Feb 2016
Comparison of Two Methods of Transfusion for Stroke Prevention in Sickle CellChattanooga-Hamilton County Hospital Authority1 Aug 20151 Jun 2017
Comparison of Patient Centered Outcomes for People With SCD in the Acute Care SettingJohns Hopkins University1 Jul 20151 Dec 2018
Safety Of Rivipansel (GMI-1070) In The Treatment Of One or More Vaso-occlusive Crises In Hospitalized Subjects With Sickle Cell DiseasePfizerRivipansel, GMI-1070, Selectin Inhibitor, SCD, VOC1 Jul 20151 Feb 2020
Sevuparin Infusion for the Management of Acute VOC in Subjects With SCDDilaforette AB1 Jul 20151 Jun 2016
Carbon Monoxide Measurement to Screen for Sickle Cell DiseaseChildren's Hospital & Research Center OaklandSickle Cell Anemia1 Jul 20151 Dec 2015
Macitentan in Pulmonary Hypertension of Sickle Cell DiseaseBoston UniversityPulmonary Hypertension, Sickle Cell Disease, Pulmonary Arterial Hypertension, Macitentan1 Jul 20151 Dec 2016
Evaluation of Repeat Administration of Purified Poloxamer 188Mast Therapeutics, Inc.Sickle cell, vaso-occlusive crisis1 Jun 20151 Jun 2016
Music Therapy in Sickle Cell Transition StudyUniversity Hospital Case Medical Center1 Jun 20151 Aug 2016
Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia PatientsKevin H.M. Kuo, MD, MSc, FRCPC1 Jun 20151 Jun 2018
SMART Mobile Application Technology Utilization in the Treatment of Sickle Cell Disease Post Day Hospital DischargeDuke UniversitySickle Cell Disease1 Jun 20151 May 2017
A Study to Evaluate the Effect of Ticagrelor in Reducing the Number of Days With Pain in Patients With Sickle Cell DiseaseAstraZenecaSickle cell disease, Young adults, Hestia2, Ticagrelor1 Jun 20151 Jun 2016
A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male SubjectsGlobal Blood Therapeutics1 Jun 20151 Dec 2015
Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other AnemiasApoPharmaIron overload, Sickle cell disease, Deferiprone, Ferriprox, Iron chelation1 May 20151 Oct 2018
Arginine Therapy for the Treatment of Pain in Children With Sickle Cell DiseaseEmory University1 May 20151 Jul 2019
Gene Therapy for Transfusion Dependent Beta-thalassemiaIRCCS San RaffaeleBeta thalassemia, Gene therapy, Lentiviral vector1 May 20151 Aug 2019
Study of SANGUINATE™ In the Treatment of Sickle Cell Disease Patients With Vaso-Occlusive CrisisProlong Pharmaceuticals1 Apr 20151 Apr 2016
Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta ThalassemiaTanta University1 Apr 20151 Apr 2017
Mental Health Treatment in Sickle Cell DiseaseUniversity of Pittsburgh1 Mar 20151 Dec 2015
Effect of Spirulina on Liver Iron Concentration in Beta Thalassemic Children With Hepatitis CTanta University1 Mar 20151 Dec 2016
Comparing Acute Pain Management Protocols for Patients With Sickle Cell DiseaseDuke UniversitySickle Cell Disease, Emergency Department, Vaso-occlusive Crisis, Pain Management, Pilot Project1 Feb 20151 Sep 2016
Dose-Escalation Study of SCD-101 in Sickle Cell DiseaseInvenux, LLCHomozygous Sickle Cell Disease S/Beta 0 Thalassemia1 Feb 20151 Jan 2016
Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?Ain Shams University1 Feb 20151 Dec 2017
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell DiseaseGlobal Blood Therapeutics1 Jan 20151 May 2016
Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Genotype 1 or 4 HCV Infected Adults With Sickle Cell DiseaseGilead SciencesSickle Cell Disease, Gilead, Hepatitis C1 Dec 20141 Mar 2016
Treatment of Hemoglobin Sickle Cell DiseaseBaylor College of MedicineHemoglobin SC disease, hydroxyurea, quality of life, viscosity, red cell density1 Dec 20141 Dec 2019
Biological, Genetic and Environmental Involved in the Complications of Sickle Cell DiseaseErasme University Hospitalsickle cell disease, nephropathy20 Oct 20141 Jan 2025
PATient Navigator to rEduce ReadmissionsUniversity of Illinois at ChicagoPatient Navigators, Readmissions, Peer Coaching1 Oct 20141 Apr 2016
A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell DiseaseSt. Jude Children's Research HospitalParvovirus B19 Infection1 Oct 20141 May 2017
ACE-536 Extension Study - Beta ThalassemiaAcceleron Pharma, Inc.1 Oct 20141 Apr 2017
Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-ThalassemiaSideris PharmaceuticalsChelation, Iron Overload, Thalassemia, Transfusion, Iron Chelation1 Oct 20141 Jul 2015
Feasibility and Efficacy of a Home-based, Computerized Cognitive Training Program in Pediatric Sickle Cell DiseaseSteven J. HardyNeurocognitive, Working memory, Cogmed, Cognitive training1 Oct 20141 Aug 2017
Vitamin D3 in Patients With Sickle Cell DiseaseIcahn School of Medicine at Mount SinaiSickle Cell Disease, Vitamin D1 Oct 20141 Dec 2017
Assessment of Tolerance of Mobilizing Peripheral Hematopoietic Stem Cells by Plerixafor in Sickle Cell PatientsAssistance Publique - Hôpitaux de ParisSickle cell disease, Open monocenter study, Phase I/II, hematopoietic stem cells, Plerixafor1 Sep 20141 Jun 2017
A Pharmacokinetic (PK) and Pharmacodynamic (PD) Dose-ranging Phase II Study of Ticagrelor Followed by a 4 Weeks Extension Phase in Paediatric Patients With Sickle Cell DiseaseAstraZenecasickle cell anemia, paediatric1 Sep 20141 Sep 2015
Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant DiseasesBellicum PharmaceuticalsSevere Combined Immune Deficiency, Congenital T-cell Defect, Congenital T-cell Deficiency, Chronic Granulomatous Disease, Shwachman Diamond Syndrome, Diamond Blackfan Anemia, Dyskeratosis Congenita, Fanconi Anemia, Sickle Cell Disease, Thalassemia, Mucopolysaccharidosis, Sphingolipidoses1 Sep 20141 Dec 2018
Music Therapy in Sickle Cell Pain RCTUniversity Hospital Case Medical CenterMusic Therapy, Sickle Cell Disease, Pain1 Sep 20141 Jun 2016
Decision Aid for Therapeutic Options In Sickle Cell DiseaseEmory UniversityHydroxyurea, Bone marrow transplant, Chronic blood transfusion, Treatment options for sickle cell disease, Decision making1 Sep 20141 Dec 2016
Denosumab vs Placebo in Patients With Thalassemia Major and OsteoporosisErsi Voskaridou1 Sep 20141 Dec 2016
A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in Severe Sickle Cell Diseasebluebird bio1 Aug 20141 Jan 2018
Haploidentical Hematopoietic Stem Cell Transplantation for Children With Sickle Cell Disease and Thalassemia Using CD34+ Positive Selected GraftsCatherine Bollard1 Aug 20141 Dec 2019
Fertility Preservation in Women Who Will be Undergoing Gonadotoxic Therapy, Hematopoietic Stem Cell Transplantation, and in Women With Sickle Cell DiseaseEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Bone Marrow Transplant, Fertility, Ovary1 Aug 20141 Aug 2019
Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)Hydroxyurea, Sickle Cell Disease, Fetal Hemoglobin Induction1 Aug 20141 May 2018
Working Memory and School Readiness in Preschool-Aged Children With Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Aug 20141 Mar 2017
Study of Beet Juice for Patients With Sickle Cell AnemiaDaniel Kim-ShapiroErythrocyte Deformability, Platelet Activation, Platelet Aggregation, Nitrite, Sickle Cell Anemia, Diet Therapy1 Jul 20141 Apr 2015
Stem Cell Gene Therapy for Sickle Cell DiseaseDonald B. Kohn, M.D.Sickle Cell Disease (SCD), Gene Therapy, Lentiviral Vector, Beta Globin1 Jul 20141 Apr 2018
Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Study Of PF-04447943, Co-Administered With And Without Hydroxyurea, In Subjects With Stable Sickle Cell DiseasePfizer1 Jun 20141 Apr 2015
Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia MajorAffiliated hospital of guangxi medical university,chinabeta-Thalassemia major1 Jun 20141 Dec 2018
Patient Centered Comprehensive Medication Adherence Management System in Patients With Sickle Cell DiseaseEmory University1 Jun 20141 Dec 2018
Sickle Cell Disease (SCD) Decision AidEmory University15 May 201431 Mar 2015
Phase II Study to Investigate the Benefits of an Improved Deferasirox Formulation (Film-coated Tablet)Novartis PharmaceuticalsIron overload, Chelation, Thalassemia, Myelodysplastic syndrome (MDS), Transfusional hemisiderosis, Deferasirox, ICL670, Dispersible tablet, Film-coated tablet1 May 20141 Dec 2015
Use of Mobile Technology for Intensive Training in Medication ManagementDuke UniversitySickle cell, Thalassemia, Adherence1 May 20141 May 2016
Medication Adherence in Youth With Sickle Cell Disease (SCD)St. Jude Children's Research HospitalMedication Adherence, Hydroxyurea1 May 20141 May 2015
Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg UlcersNational Human Genome Research Institute (NHGRI)Genetic Disorders, Sickle Cell Disease, African American, Leg Ulcers, Skin1 May 20141 Apr 2016
Sickle Cell Hemoglobinopathies and Bone HealthUniversity of Connecticut Health CenterSickle Cell Disease (SCD), Sickle Cell Trait (SCT)1 May 20141 May 2017
Feasibility Study of Unfractionated Heparin in Acute Chest SyndromeUniversity of PittsburghSickle cell disease, Acute chest syndrome, Hemoglobinopathy, Hemolytic anemia, Heparin, Anticoagulant1 Apr 20141 Apr 2016
Gum Arabic as Fetal Hemoglobin Agent in Sickle Cell AnemiaAl-Neelain University1 Apr 20141 Jan 2015
Androgen Regulation of Priapism in Sickle Cell DiseaseJohns Hopkins UniversityPriapism, Sickle cell disease, Male1 Mar 20141 Sep 2017
Hematopoietic Stem Cell Transplant for Sickle Cell DiseaseCase Comprehensive Cancer CenterSickle Cell Disease, Sickle Cell Anemia, GvHD, fludarabine1 Mar 20141 Nov 2016
Effect of Deferasirox on Endocrine Complications in Subjects With Transfusion Dependent ThalassemiaNovartis PharmaceuticalsEndocrine complications, transfusion dependent thalassemia1 Mar 20141 Mar 2018
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant FailureNational Heart, Lung, and Blood Institute (NHLBI)Sickle Cell Disease, Allogeneic Hematopoietic Stem Cell Transplant, Pentostatin (Nipent), Cyclophosphamide, Alemtuzumab (Campath)1 Mar 20141 Aug 2021
Sickle Cell Clinical Research and Intervention ProgramSt. Jude Children's Research HospitalSickle Cell Anemia, Sickle Cell Disease, Survival, Mortality, End-Order Dysfunction1 Mar 20141 Dec 2044
Hepcidin Levels in Sickle Cell Disease (SCD)Kenneth Ataga, MDsickle cell disease1 Mar 20141 May 2015
Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other AnemiasApoPharmasickle cell disease, Iron overload, Deferiprone, Ferriprox, deferoxamine, Chelation1 Feb 20141 Mar 2016
Study of Efficacy and Safety of INC424 in Regularly Transfused Patients With Thalassemia.Novartis Pharmaceuticalsthalassemia, spleen enlargement1 Feb 20141 Feb 2016
Amlodipine for Myocardial Iron in ThalassemiaAga Khan UniversityThalassemia, Amlodipine, Chelation, T2*, MRI, Myocardial Iron1 Feb 20141 May 2015
The Effect of Rivaroxaban in Sickle Cell DiseaseUniversity of North Carolina, Chapel Hillsickle cell anemia, sickle cell disease, rivaroxaban, direct Xa inhibition, coagulation, anticoagulation1 Feb 20141 Sep 2016
Novel Use Of Hydroxyurea in an African Region With MalariaUniversity of Minnesota - Clinical and Translational Science InstituteHydroxyurea1 Jan 20141 Jan 2017
Allograft for Sickle Cell Disease and ThalassemiaUniversity of Texas Southwestern Medical CenterSickle Cell Disease, Thalassemia1 Jan 20141 Jan 2018
Reduced Intensity Conditioning in Patients Aged ≤30 With Non-Malignant Disorders Undergoing Cord Blood TransplantationUniversity of PittsburghSevere Combined Immune Deficiency (SCID) with NK cell activity, Omenn Syndrome, Bare Lymphocyte Syndrome (BLS), Combined Immune Deficiency (CID) syndromes, Combined Variable Immune Deficiency (CVID) syndrome, Wiskott-Aldrich Syndrome, Leukocyte adhesion deficiency, Chronic granulomatous disease (CGD), X-linked Hyper IgM (XHIM) syndrome, IPEX syndrome, Chediak -Higashi Syndrome, Autoimmune Lymphoproliferative Syndrome (ALPS), Hemophagocytic Lymphohistiocytosis (HLH) syndromes, Lymphocyte Signaling defects, Other primary immune defects where HSCT may be beneficial, Dyskeratosis Congenita (DC), Congenital Amegakaryocytic Thrombocytopenia (CAMT), Osteopetrosis, Mucopolysaccharidoses, Hurler syndrome (MPS I), Hunter syndrome (MPS II), Sanfilippo syndrome (MPS II), Leukodystrophies, Krabbe Disease, also known as globoid cell leukodystrophy, Metachromatic leukodystrophy (MLD), X-linked adrenoleukodystrophy (ALD), Other inherited metabolic disorders, alpha mannosidosis, Other inheritable metabolic diseases where HSCT may be beneficial., Thalassemia major, Sickle cell disease (SCD), Diamond Blackfan Anemia (DBA), other congenital transfusion dependent anemias1 Dec 20131 Nov 2018
Survey in a Population of Sickle Cell Disease Patients to Evaluate the Transition Between the Queen Fabiola Children Hospital and the CHU Brugmann Hospital, and the Quality of the Hospital Care Within the CHU Brugmann Hospital.Brugmann University Hospitalpediatric hospital care, adult hospital care, sickle cell disease1 Dec 20131 Dec 2016
Phase 2 Study of Montelukast for the Treatment of Sickle Cell AnemiaVanderbilt University1 Nov 20131 Oct 2017
SCD-Haplo: A Phase II Study of HLA-Haploidentical Stem Cell Transplation to Treat Clinically Aggressive Sickle Cell DiseaseDamiano Rondelli, MD1 Nov 20131 Oct 2018
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell TransplantDiane George, MDUnrelated donor transplant, Allogenic Stem Cell Transplant, Adult Bone Marrow Transplant, Pediatric Bone Marrow Transplant, Related donor transplant, Haploidentical donor transplant, Peripheral blood stem cell transplantation, Non-malignant disease, Malignant disease, Bone marrow failure syndrome, Severe Aplastic Anemia, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia, Diamond-Blackfan Anemia, Schwachman Diamond Syndrome, Primary Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome, Histiocytic Syndrome, Familial Hemophagocytic Lymphocytosis, Lymphohistiocytosis, Macrophage Activation Syndrome, Langerhans Cell Histiocytosis (LCH), Hemoglobinopathies, Reduced-Intensity Conditioning, Sickle Cell Disease, Sickle Cell-beta-thalassemia1 Nov 20131 Dec 2017
Added Value of Speckle Tracking in the Evaluation of Patients With Sickle Cell DiseaseBrugmann University HospitalSickle Cell Disease, Echocardiography, Speckle tracking1 Nov 20131 Mar 2016
Feasibility of a Stress Reduction Intervention Study in Sickle Cell DiseaseUniversity of Illinois at Chicago1 Nov 20131 Nov 2014
Ph. 2 Study of MP4CO to Treat Vaso-occlusive Sickle CrisisSangartSickle cell anemia, Sickle cell disease, Sickling crisis, Vaso-occlusive crisis, Carboxyhemoglobin, Oxygen therapeutic, Ischemic rescue therapy, Hemoglobin solution, Pegylated hemoglobin1 Oct 20131 Oct 2015
Treatment of Iron Overload Requiring Chelation TherapyShire Development LLC1 Oct 20131 Jul 2015
Pain Management in Children and Young Adults With Sickle Cell DiseaseSt. Jude Children's Research HospitalPain control1 Oct 20131 Oct 2017
Evaluation of Nocturnal Enuresis and Barriers to Treatment Among Pediatric Patients With Sickle Cell DiseaseSt. Jude Children's Research HospitalNocturnal enuresis, Barriers to treatment1 Oct 20131 Oct 2015
Hydroxyurea Therapy, Sickle Cell Disease, NDEPTHBaylor College of MedicineSickle cell, Hydroxyurea, Dose prediction, Maximum tolerated dose1 Oct 20131 Oct 2018
Utility of Fibroscan in Estimating Hepatic Iron ConcentrationUniversity of British ColumbiaBeta Thalassemia Major1 Oct 20131 Oct 2014
Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain CrisisSt. Louis UniversitySickle Cell Pain Crisis, Abciximab, Integrins, Cell Adhesion Molecules1 Sep 20131 Sep 2015
Deferasirox BID in Transfusion Dependent Thalassemia Patients With Indadequate Response to High DosesNovartis Pharmaceuticals1 Sep 20131 Sep 2015
Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABITColumbia UniversitySickle cell disease, Medication adherence, Hydroxyurea, Community health worker intervention, Sickle Cell Treatment1 Sep 20131 May 2015
Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in IndonesiaFakultas Kedokteran Universitas Indonesia1 Sep 20131 Feb 2014
Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell DiseaseDuke Universitysickle cell disease, pulmonary hypertension, airway hyperreactivity, acute chest syndrome1 Aug 20131 Feb 2020
Improving Disease Knowledge in Adolescents With Sickle Cell DiseaseThe University of The West IndiesEducational intervention, Formal Counselling, Knowledge, Illness Perception1 Aug 20131 Aug 2015
Evaluation of Sickle Cell Liver DiseaseNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Microbiome, Sickle Cell Disease, Bone Marrow Transplant1 Aug 20131 May 2018
Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesSelexys Pharmaceuticals CorporationSelG1, P-selectin, monoclonal antibody, sickle cell disease, sickle cell anemia, sickle cell, pain crisis, pain crises, vasoocclusion, vaso-occlusion, priapism, hepatic sequestration, splenic sequestration, chest syndrome1 Jul 20131 Aug 2015
An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years OldNovartis Pharmaceuticalsdeferasirox1 Jun 20131 Oct 2014
Efficacy/Safety Study of Deferiprone Compared to Deferasirox in Paediatric PatientsConsorzio per Valutazioni Biologiche e Farmacologichechronic iron overload, hereditary haemoglobinopathy, beta thalassaemia major, chelating agents, deferiprone, deferasirox, children, paediatrics1 Jun 20131 Dec 2014
Exhaled Carbon Monoxide as a Marker of Hemolysis in Sickle Cell Disease- an Exploratory StudyUniversity Hospital Case Medical Centercarbon mono oxide, sickle cell, hemolysis1 Jun 20131 Jun 2015
Nitrous Oxide Analgesia Vaso-occlusive CrisisColumbia UniversitySickle cell disease, Vaso-occlusive crisis, Nitrous oxide, Emergency department1 Jun 20131 Jun 2014
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell DiseaseUniversity Hospital Case Medical CenterSickle cell disease, Chronic kidney disease, Bicarbonate therapy1 Jun 20131 Jun 2015
Reproductive Capacity and Iron Burden in ThalassemiaChildren's Hospital & Research Center OaklandInfertility, Thalassemia, Iron overload, Pituitary Iron Load, Oxidative Stress, REPRODUCTIVE CAPACITY AND ASSOCIATION TO IRON BURDEN AND CHELATION PATTERNS IN THALASSEMIA MAJOR PATIENTS1 Jun 20131 Jun 2016
Evaluation of the Free α-hemoglobin Pool in the Red Blood Cells : Prognostic Marker and Severity Index in Thalassemic SyndromesAssistance Publique - Hôpitaux de ParisAlpha-Hemoglobin Stabilizing Protein, alpha-Hb pool, thalassemias, diagnostic method, biomarker1 Jun 20131 Jun 2016
Absorption, Metabolism, and Excretion of a Single Dose of Ferriprox® in Patients With Sickle Cell DiseaseApoPharmasickle cell disease, iron overload, pharmacokinetics, Ferriprox, deferiprone1 May 20131 Jul 2013
Non-Myeloablative Conditioning and Bone Marrow TransplantationVanderbilt-Ingram Cancer Center1 May 20131 May 2016
Effect of Exercise With and Without HMB on Body Composition and Muscle Strength in Sickle Cell AnaemiaThe University of The West Indies30 Apr 201315 Nov 2019
A Phase II Trial of Regadenoson in Sickle Cell AnemiaDana-Farber Cancer Institute1 Apr 20131 Apr 2015
N-Acetylcysteine in Patients With Sickle Cell DiseaseAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Sickle Cell Disease, Sickle Cell Anemia, Pain, N-Acetylcysteine, Acetylcysteine, Oxidative stress1 Apr 20131 Oct 2014
A Study Evaluating the Safety and Efficacy of the Gene Therapy LentiGlobin® BB305 Drug Product in Subjects With Beta-Thalassemia MajorBluebird Biogene therapy, beta thalassemia, hemoglobin, anemia, CD341 Mar 20131 Jul 2017
A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)Eli Lilly and Company1 Mar 20131 Jun 2015
CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant DiseaseDiane George, MDUnrelated donor transplant, Haploidentical donor transplant, Peripheral blood stem cell transplantation, CD34+ selection, Non-malignant disease, Bone marrow failure syndrome, Severe Aplastic Anemia, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia, Diamond-Blackfan Anemia, Schwachman Diamond Syndrome, Primary Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome, Histiocytic Syndrome, Familial Hemophagocytic Lymphocytosis, Lymphohistiocytosis, Macrophage Activation Syndrome, Langerhans Cell Histiocytosis (LCH), Hemoglobinopathies, Sickle Cell Disease, Sickle Cell-beta-thalassemia1 Mar 20131 Mar 2017
Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD)NKT TherapeuticsSickle cell disease1 Feb 20131 Aug 2014
Sickle Cell Disease - Stroke Prevention in Nigeria TrialVanderbilt Universitytranscranial Doppler, stroke, sickle cell anemia, Nigeria, hydroxyurea, low income country1 Feb 20131 Aug 2014
Implications of a Paediatrician-psychologist Tandem for Sickle Cell Disease Care and Impact on Cognitive FunctioningFondation Ophtalmologique Adolphe de Rothschildpaediatric-psychological partnership, child, mental health, integrated care, well-being1 Feb 20131 Apr 2014
Microvascular and Fibrosis Imaging StudyDuke UniversityAutoimmune diseases with cutaneous involvement, Systemic sclerosis, Scleroderma, Morphea, Dermatomyositis, Cutaneous lupus, Vasculitis, Sickle Cell Disease, Graft versus Host Disease1 Jan 20131 Jan 2017
Vaporized Cannabis for Chronic Pain Associated With Sickle Cell DiseaseUniversity of California, San Francisco1 Jan 20131 Mar 2016
Anthropometric Measurements in Children Having Transfusion-dependent Beta ThalassemiaAga Khan University1 Jan 201331 Dec 2014
Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC TransfusionCerus CorporationS303 treated RBCs1 Dec 20121 Jun 2014
Pharmacokinetic Study of Deferiprone in Paediatric PatientsConsorzio per Valutazioni Biologiche e Farmacologichechronic iron overload, hereditary haemoglobinopathy, beta thalassaemia major1 Dec 20121 Apr 2013
Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC)Adventrx Pharmaceuticalssickle cell disease, vaso-occlusive crisis1 Dec 20121 Aug 2015
An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study)Novartis Pharmaceuticals1 Dec 20121 Jul 2014
Study of ACE-536 to Evaluate the Effects of ACE-536 in Patients With Beta-thalassemia IntermediaAcceleron Pharma, Inc.1 Dec 20121 Nov 2014
Evaluation of Spectra Optia RBC Exchange in Sickle Cell PatientsCaridianBCT1 Nov 20121 May 2013
Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood DisordersMassachusetts General HospitalKidney, Chronic Kidney Disease, CKD, Bone Marrow, Bone Marrow Transplant, BMT, Leukemia, AML, ALL, CML, CLL, MM, NHL, MDS1 Nov 20121 Jan 2015
Zinc and Diabetes in Patients With Thalassemia: a Pilot StudyChildren's Hospital & Research Center OaklandThalassemia, Diabetes, Zinc, Iron-Overload1 Nov 20121 Dec 2014
The Use of Warmed Saline in Vaso-occlusive EpisodesNationwide Children's Hospital1 Nov 20121 Jun 2014
Single-center Prospective Evaluation of Sickle Cell Patient Care in the CHU Brugmann Emergency DepartmentBrugmann University HospitalSickle Cell Disease, Vaso-occlusive crisis, Emergency management1 Nov 20121 May 2015
An Open Label, Multi-center, Efficacy and Safety Study of Deferasirox in Iron Overloaded Patients With Non-transfusion Dependent ThalassemiaNovartis PharmaceuticalsNon-transfusion dependent thalassemia, NTDT1 Oct 20121 Apr 2014
Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) Follow-up Observational Study II ProtocolNational Heart, Lung, and Blood Institute (NHLBI)1 Oct 20121 Dec 2016
Cognitive Rehabilitation in Sickle Cell DiseaseDuke Universitysickle cell disease, pediatric, learning disability, cognitive impairment, memory, attention, Children with sickle cell disease1 Oct 20121 Mar 2014
Carbon Monoxide Monitor for the Measurement of End-Tidal Carbon Monoxide Levels in Children With or Without HemolysisAshutosh Lal1 Oct 20121 Oct 2013
Sickle Cell Trait in Football PlayersUniversity of South FloridaSickle Cell Trait, Football, Sickling, Heat Illness, SCT1 Oct 20121 Aug 2013
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient NavigatorsVirginia Commonwealth Universitysickle cell disease, hydroxyurea, patient navigator, community health worker, public health worker, fetal hemoglobin, health services research1 Oct 20121 Aug 2016
Combination Deferasirox and Deferiprone for Severe Iron Overload in ThalassemiaChildren's Hospital of PhiladelphiaThalassemia, Chelation, Transfusion, Safety1 Sep 20121 Aug 2015
Unrelated Umbilical Cord Blood Following HLA-haploidentical Hematopoietic Stem Cell Transplantation in Patients With β-thalassemia MajorNanfang Hospital of Southern Medical UniversityCord Blood Transplant, Haploidentical HSCT, Thalassemia major1 Sep 20121 Jun 2015
ß-Thalassemia Major With Autologous CD34+ Hematopoietic Progenitor Cells Transduced With TNS9.3.55 a Lentiviral Vector Encoding the Normal Human ß-Globin GeneMemorial Sloan-Kettering Cancer CenterBUSULFAN, G-CSF, CliniMACS-CD34 Reagent System, Blood transfusion, 10-164, Autologous CD34+ cells transduced with TNS9.3.55, a lentiviral vector encoding the human β-globin gene1 Jul 20121 Jul 2014
Liver Fibrosis in Sickle Cell DiseaseUniversity of Miamisickle cell disease, hemochromatosis, liver fibrosis, liver cirrhosis, FibroScan, MRI R2*, liver iron1 Jul 20121 Dec 2017
Post Hematopoietic Stem Cell TransplantationNovartis Pharmaceuticalshematopoietic stem cell transplantation, beta-thalassemia major, deferasirox, iron overload1 Jun 20121 Jul 2014
Therapeutic Effect and Safety of Combined Hydroxyurea With Recombinant Human Erythropoietin.Ain Shams UniversityHydroxyurea, Erythropoitin therapy, Thalassemia intermedia1 Jun 20121 Dec 2012
Immunomodulatory Effects of Silymarin in Patients With Beta-Thalassemia MajorShiraz University of Medical SciencesFocus, immunomodulatory effect, of silymarin, on cell mediated immunity, Beta-Thalassemia, major patients.1 Jun 20121 Sep 2012
Use of a Mobile-based App for SCD PatientsJude C. JonassaintSickle cell, Pain1 Jun 20121 Jun 2014
Trial of HQK-1001 in Beta Thalassemia Intermedia in LebanonBoston UniversityThalassemia intermedia, Fetal hemoglobin, Hemoglobin1 May 20121 Jan 2013
Massive Iron Deposit AssessmentSt. Jude Children's Research HospitalSickle cell disease, Thalassemia, Hemochromatosis, Cancer1 Apr 20121 Apr 2017
Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta( β)- Thalassemia.Celgene CorporationBeta-Thalassaemia1 Mar 20121 Jun 2014
Study of SDMB in Beta Thalassemia Intermedia in ThailandBoston UniversityThalassemia, Anemia, Fetal hemoglobin1 Mar 20121 Dec 2012
Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused PopulationsAssistance Publique - Hôpitaux de ParisThalassemia, sickle cell disease, myelodysplasia, transfusion, chelation1 Mar 20121 Mar 2015
Effects of Transfusion of Older Red Blood Cells on Patients With HemoglobinopathiesColumbia Universityiron, transfusion, red blood cells, sickle cell disease, thalassemia, blood donors1 Feb 20121 Feb 2015
Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron OverloadAin Shams UniversityIron chelation, Iron balance, Secondary iron overload, deferoxamine, deferasirox, Deferiprone, 1- Beta-thalassemia major patients;, Patients with high iron stores, Serum ferritin consistently > 2500 mcg/l and or increasing trend over previous 12 months, Liver iron >14 mg/g dry weight- by R2 MRI, 2- Sickle cell disease, 3- Other causes of transfusional iron hemosiderosis1 Feb 20121 Feb 2013
Prevalence of Pulmonary Hypertension (PAH) in Patients With ThalassemiaEnte Ospedaliero Ospedali GallieraThalassemia, Pulmonary Arterial Hypertension1 Jan 20121 Jan 2013
Safety Study of MP4CO in Adult Sickle Cell PatientsSangartSickle cell anemia, Sickle cell disease, Sickling crisis, Vaso-occlusive crisis, Carboxyhemoglobin, Oxygen therapeutic, Hemoglobin solutions, Pegylated hemoglobin1 Jan 20121 Mar 2013
Effect of Metoprolol on Thalassemia CardiomyopathyShiraz University of Medical SciencesThalassemia cardiomyopathy, metoprolol succinate, echocardiography, six minute walk test1 Jan 20121 Dec 2012
Functional Neuroimaging of Pain Using EEG and fMRIUniversity of Minnesota - Clinical and Translational Science InstituteSickle Cell1 Jan 20121 May 2015
Demographic, Clinical, Laboratory and Genetical Characteristics of Patients With Beta Thalassemia IntermediaHaEmek Medical Center, IsraelBeta globin gene, Alfa globin gene, xmn1 polymorphism1 Oct 20111 Dec 2012
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)Center for International Blood and Marrow Transplant Research1 Oct 2011
Providing Access to Cord Blood Units for TransplantsNational Cancer Institute (NCI)Adult and Pediatric, Unlicensed Cord Blood Unit IND, NMDP, Transplant, Hematologic Malignancies, Leukemia, Multiple Myeloma, Non-Hodgkin Lymphoma, CML, Chronic Myelogenous Leukemia, Myelodyplastic Syndrome, MDS, Thalassemia, Lysosomal Storage Diseases1 Oct 20111 Nov 2012
Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia MajorUniversity of Campinas, BrazilMagnetic resonance imaging, Thalassemia, Iron overload1 Aug 20111 Dec 2013
Study of Effects of YisuiShengxueGranules on ThalassemiaGuang'anmen Hospital of China Academy of Chinese Medical Sciencestraditional chinese medicine and thalassemia1 Jul 20111 Jan 2012
Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron OverloadShire Development LLCBeta-Thalassemia, Sickle Cell Anemia, Transfusional iron overload, Iron Overload, Iron Chelation1 Jul 20111 Dec 2013
The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response StudyWeill Medical College of Cornell UniversityThalassemia, hypercalciuria, vitamin D, To conduct a pilot study to determine the effect of various doses of, vitamin D supplementation on vitamin D stores and their association with calcium excretion1 Jun 20111 Dec 2014
Stem Cell Transplantation for Sickle Cell AnemiaHackensack University Medical CenterStem cell transplant, Sickle cell, Stem cell transplantation, Related, Unrelated1 Jun 20111 Jun 2018
Patient-Provider Tools to Improve the Transition to Adult Care in Sickle Cell DiseaseChildren's Hospital Medical Center, CincinnatiAnemia, Sickle Cell, Transition to Adult Care, Self Care, Personal Electronic Health Records, Adolescent, Young Adult, Disease Management, Physician-Patient Relations1 Jun 20111 Jul 2015
Phase I/II Pilot Study of Mixed Chimerism to Treat HemoglobinopathiesUniversity of Louisvilleother hemoglobinopathies, chimerism, sickle cell, thalassemia, Marrow/Enriched Hematopoetic Stem Cell Transplant1 May 20111 May 2030
High-Tc Susceptometer to Monitor Transfusional Iron OverloadColumbia UniversityIron, Iron overload, Hepatic iron concentration, High-temperature superconductivity, Magnetic susceptibility, Susceptometer1 Mar 20111 May 2014
Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood DisordersNational Heart, Lung, and Blood Institute (NHLBI)Sickle Cell Disease, Hemolysis, Anemia, Nitric Oxide, Blood Flow, Leg Ulcer, Sickle Cell Anemia, Thalassemia, Hemolytic Blood Disorder1 Mar 20111 Apr 2013
Study of Panobinostat (LBH589) in Patients With Sickle Cell DiseaseAbdullah Kutlarsickle cell anemia, sickle cell thalassemia, HDAC inhibitor, hemoglobin F, sickle beta thalassemia1 Nov 20101 Dec 2014
Evaluating the Safety and Effectiveness of Mozobil Mobilization in Adults With Beta-Thalassemia MajorUniversity of WashingtonBeta Thalassemia Major, Hematopoietic Stem Cell Mobilization, Gene Transfer Techniques1 Oct 20101 Dec 2012
A Randomized Trial of LOVAZA in Pediatric Sickle Cell Disease (SCD)Thomas Jefferson UniversitySickle Cell Anemia, Sickle Cell Disease, Hemoglobin SS Disease, Hemoglobin S beta-0 Thalassemia, Inflammation, Quality of Life, Sickle Thalassemia, C-Reative Protein, Hemolytic Anemia, Hemostasis, Biomarkers, Coagulation, Omega-3 Fatty Acids, Eicosapentaenoic Acid, Docosahexaenoic Acid, Fish Oils, Drug: Placebo, Drug: LOVAZA1 Oct 20101 Mar 2012
B Memory Cell Response to Vaccination With the 13-valent Pneumococcal Conjugate Vaccine in Asplenic IndividualsAghia Sophia Children's Hospital of Athens1 Oct 20101 Feb 2012
Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationEmory Universitybone marrow transplant, sickle cell disease, thalassemia, Glanzmann thrombasthenia, Wiskott-Aldrich syndrome, chronic-granulomatous disease, severe congenital neutropenia, leukocyte adhesion deficiency, Schwachman-Diamond syndrome, Diamond-Blackfan anemia, Fanconi anemia, dyskeratosis-congenita, Chediak-Higashi syndrome, severe aplastic anemia1 Sep 20101 Sep 2015
GDF 15 in Sickle Cell Disease and Hereditary SpherocytosisWolfson Medical Center1 Sep 20101 Sep 2011
Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron OverloadShire Development LLCBeta-thalassemia, Sickle cell anemia, Transfusional iron overload, Iron overload, Iron chelation1 Aug 20101 Jan 2013
Genes Influencing Iron Overload StateSt. Jude Children's Research HospitalIron overload, Blood Transfusion1 Aug 20101 Jul 2016
Safety and Efficacy of Deferasirox in β-thalassaemia Patients With Severe Cardiac Iron OverloadNovartis PharmaceuticalsSevere cardiac iron overload, deferasirox, β-thalassaemia, cardiac dysfunction1 Jul 20101 Dec 2014
Sickle Cell Trait and the Risk of Venous ThromboembolismAlbert Einstein College of Medicine of Yeshiva Universitysickle cell trait, thrombosis, D-Dimer1 Jul 20101 Dec 2012
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell DiseaseUniversity of Miamisickle cell disease, propanolol, red blood cell adhesion1 Jun 20101 Dec 2016
A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemiaEmmaus Medical, Inc.Sickle Cell Anemia, Sickle Cell Pain Crises, Painful Crises, Sickle Cell Pain, Vaso-occlusive Crises1 May 20101 Feb 2013
Perceptions of Thalassemia Major in Singapore: An Exploratory Study of StigmaNational Human Genome Research Institute (NHGRI)Thalassemia Major, Stigma, Singapore, Qualitative1 Apr 2010
Beta-thalassemia and MicroparticlesAssistance Publique Hopitaux De MarseilleTM, TI, MP1 Mar 20101 Mar 2013
Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension Study (THALASSA)Novartis PharmaceuticalsThalassemia,, thalassemia intermedia,, alpha-thalassemia,, beta-thalassemia,, deferasirox,, iron overload,, non-transfusion dependent1 Mar 20101 Jun 2012
Multi-Center Study of Iron Overload: Survey Study (MCSIO)Children's Hospital & Research Center Oakland1 Mar 20101 Oct 2013
Efficacy and Safety of Desferal Versus Osveral in Transfusional Iron OverloadHormozgan University of Medical SciencesThalassemia, Iron overload, transfusion, osveral, desferal1 Feb 20101 May 2011
Reduced Intensity Transplant Conditioning Regimen for Severe ThalassemiaWashington University School of MedicineThalassemia, Alemtuzumab, Hematopoietic cell transplant, non-myeloablative1 Jan 20101 Sep 2011
This Study Will Evaluate Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndromes (MDS), Thalassemia and Rare Anemia Types Having Transfusion-induced Iron Overload.Novartis PharmaceuticalsIron Overload, hemotranfusion, deferasirox, ferritin, Rare anemia, Transfusional Iron Overload1 Dec 20091 Sep 2011
Zoledronic Acid for the Prevention of Bone Loss Post-bone Marrow Transplantation for Thalassemia Major PatientsTehran University of Medical SciencesThalassemia, BMT, HSCT1 Nov 20091 Dec 2011
Multi-Center Study of Iron Overload: Pilot StudyChildren's Hospital & Research Center Oakland1 Nov 20091 Sep 2012
Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron OverloadFerroKin BioSciences, Inc.Beta-thalassemia, Sickle cell anemia, Transfusional iron overload, Iron overload, Iron chelation1 Nov 20091 Dec 2010
Demographic, Clinical and Laboratory Characteristics of Children With Alpha Thalassemia in Northern IsraelHaEmek Medical Center, Israel1 Oct 20091 Dec 2010
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-ThalassemiaNational Heart, Lung, and Blood Institute (NHLBI)Peripheral Blood Stem Cell Transplantation, Anemia, Sickle Cell, Graft-Versus-Host Disease, Sirolimus (Rapamune(Registered Trademark)), Alemtuzumab (Campath(Registered Trademark)), Thalassemia, Sickle Cell Disease1 Sep 20091 Aug 2015
Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood TransfusionsNational Heart, Lung, and Blood Institute (NHLBI)Transfusion-Dependant Thalassemia, Pain, Mild Pain1 Jul 20091 Oct 2010
Traditional Chinese Medicine in the Supportive Management of Anaemic and Cytopenic (Leukopenia, Thrombocytopenia) Haematological DisordersSingapore General HospitalChronic cytopenic haematological diseases, Chinese herbal concoction, Supportive management1 Jul 20091 Aug 2011
Treosulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited DisordersFred Hutchinson Cancer Research Center/University of Washington Cancer ConsortiumNonmalignant diseases, nonmalignant inherited disorders, primary immunodeficiency diseases, primary immune deficiency disorders, Chronic granulomatous disease, IPEX syndrome, hemophagocytic lymphohistiocytosis, Wiskott Aldrich Syndrome, bone marrow failure syndromes, Shwachman Diamond Syndrome, Dyskeratosis Congenita, Diamond Blackfan Anemia, inborn errors of metabolism, metabolic diseases, hemoglobinopathies, sickle cell disease, thalassemia, reduced intensity transplantation, hematopoietic cell transplantation, bone marrow transplantation, umbilical cord blood transplantation1 Jul 20091 Jul 2017
Families Taking Control (FTC): Family-based Problem-solving Intervention for Children With Sickle Cell DiseaseUniversity of Pennsylvania1 Jul 20091 Aug 2012
Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E PatientsMahidol UniversityThalassemia, Oxidative stress, antioxidant cocktail1 Jun 20091 Jun 2011
Blood Transfusions in Thalassemia Patients, Complications and Adverse EffectsHaEmek Medical Center, IsraelBlood transfusions, Adverse events, Hepatitis C, HIV1 May 20091 Nov 2010
Phase 1/2 Study of HQK-1001 in Patients With Beta ThalassemiaHemaQuest Pharmaceuticals Inc.1 Mar 20091 May 2010
Sildenafil to Improve Exercise Capacity in People With Thalassemia and Pulmonary HypertensionNational Heart, Lung, and Blood Institute (NHLBI)Pulmonary Hypertension1 Mar 20091 Nov 2010
Therapeutic Effects of Silymarin in Patients With B-thalassemia MajorIsfahan University of Medical Sciencesiron overload condition, regular desferrioxamine administration, receiving continuous blood transfusions1 Mar 20091 Dec 2009
Assessment of Pain in People With ThalassemiaNational Heart, Lung, and Blood Institute (NHLBI)Transfusion-Dependent Thalassemia, Non-Transfusion-Dependent Thalassemia1 Mar 20091 Dec 2010
Glutamine Therapy for Hemolysis-Associated Pulmonary HypertensionChildren's Hospital & Research Center OaklandPulmonary Hypertension, Sickle Cell Disease, Thalassemia1 Mar 20091 Mar 2013
Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCsStanford University1 Mar 20091 Aug 2013
The Spleen in Sickle Cell Anemia and Sickle Cell ThalassemiaHaEmek Medical Center, IsraelSplenectomy, Thrombocytosis, Infections, Spleen, Sickle Cell Thalassemia1 Feb 20091 Aug 2010
Effect of Deferasirox on Patients With Cardiac MRI T2* < 20 MsecNovartis PharmaceuticalsThalassemia, cardiac MRI T2*1 Feb 20091 May 2011
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell AnemiaHaEmek Medical Center, IsraelThalassemia Major, Thalassemia Intermedia, Sickle Cell Anemia, Sickle Cell Thalassemia, Iron Overload, Growth Velocity1 Jan 20091 Jul 2010
Interferon and Ribavirin Treatment in Patients With HemoglobinopathiesAzienda Ospedaliera V. Cervelloantiviral treatment in hemoglobinopathies, management of chronic viral hepatitis C infection, antiviral treatment1 Jan 20091 Dec 2013
European Sickle Cell Disease Cohort - HydroxyureaADDMEDICA SASA1 Jan 20091 Dec 2018
Fresh Versus Old Red Blood Cells for TransfusionColumbia Universityred blood cells, transfusion, storage, sickle cell disease, β-thalassemia1 Dec 20081 Mar 2011
HSCT For Patients With High Risk Hemoglobinopathies Using Reduced IntensityNorth Shore Long Island Jewish Health SystemReduced Intensity Conditioning Regimen1 Dec 20081 Jan 2017
Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron OverloadNovartis PharmaceuticalsThalassemia, thalassemia intermedia, alpha-thalassemia, beta-thalassemia, deferasirox, iron overload, non-transfusion dependent1 Nov 20081 Jun 2011
Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia MajorUniversity of Campinas, Brazilthalassemia major, calcium channel blockade, magnetic resonance imaging1 Sep 20081 Jul 2011
Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell ThalassemiaHaEmek Medical Center, IsraelSickle Cell Anemia, Sickle Cell Thalassemia, Iron overload, Non transferrin binding iron, Hepcidin1 Sep 20081 Dec 2010
Evaluation of Non-invasive Endothelial Function in Children Sickle by Vascular UltrasoundUniversity Hospital, Toulouseendothelial function, flow-mediated dilation, vascular elastic properties1 Sep 20081 Sep 2016
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood CellsChildren's Hospital Los Angelesunrelated, BMT, HSCT, bone marrow transplantation, sickle cell disease, thalassemia, CGD, HLH, Blackfan-Diamond anemia, Hurler, leukodystrophy, LAD I, Genetic diseases, Red blood cell defects, Sickle cell disease, Thalassemia, Leukocyte defects and immune deficiencies, Hereditary Lymphohistiocytosis, chronic granulomatous disease, Wiskott-Aldrich syndrome, Chediak Higashi syndrome, CD40 ligand deficiency, Hyper IgM syndrome, leucocytes adhesion defect type 1, Osteopetrosis, congenital neutropenia, X-linked lymphoproliferative disease, Platelets defects, Congenital amegakaryocytic thrombocytopenia, Metabolic and storage disorders, Hurler disease, leukodystrophies, Niemann-Pick disease, Fucosidosis, Stem cell defects, reticular agenesis1 Aug 20081 Aug 2012
Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant DisordersDuke UniversityImmunodeficiencies, Congenital Marrow Failures, Hemoglobinopathies, Inborn Errors of Metabolism, SCIDS, Wiskott Aldrich, FEL, HLH, IPEX, LAD, Sickle Cell, Thalassemia, Omenn's Syndrome, Hurler's Syndrome, MLD, ALD, Sanfilippo, Krabbe, Hunter's syndrome, TaySachs, Diamond Blackfan Anemia, transplant, MPS, Gaucher1 Aug 20081 Dec 2013
Iron Balance Study of Deferasirox, Deferoxamine and the Combination of BothWeill Medical College of Cornell UniversityIron chelation, Iron balance, Secondary iron overload, deferoxamine, deferasirox1 Aug 20081 Dec 2009
Oral Nifedipine to Treat Iron OverloadNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Nifedipine, Thalassemia, Hemochromatosis, Iron Overload, Iron Excretion1 Jun 20081 Sep 2010
Sickle Cell Anemia Screening and Prevention in Northern IsraelHaEmek Medical Center, IsraelThalassemia, Sickle cell anemia, Carrier detection, Prenatal Diagnosis, Genetic counseling1 May 2008
Clinical Diagnosis of Teenagers Admitted to Pediatric DepartmentsHaEmek Medical Center, Israel1 May 2008
Clinical and Laboratory Characteristics of Sickle Cell Anemia Patients Admitted With FeverHaEmek Medical Center, IsraelFever, Blood cultures1 May 20081 Nov 2008
Diabetic Retinopathy and Sickle TraitMedical University of South CarolinaDiabetic Retinopathy, Sickle Cell Trait, Vision Loss, Eye disease1 May 20081 Jul 2010
Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia MajorMemorial Sloan-Kettering Cancer CenterGCSF1 Apr 20081 Feb 2011
Pilot Study for Patients With Poor Response to DeferasiroxChildren's Hospital BostonThalassemia, Iron, Chelation1 Mar 20081 Nov 2008
Evaluating the Safety and Effectiveness of Decitabine in People With Thalassemia IntermediaNational Heart, Lung, and Blood Institute (NHLBI)Thalassemia Intermedia1 Jan 20081 Sep 2010
MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions.Sheba Medical Centeriron overload, Thalassemia, Anemia, Sickle Cell, Magnetic Resonance Imaging1 Jan 20081 May 2010
Far Infrared Radiation for Sickle Cell Pain ManagementGAAD Medical Research Institute Inc.HEMOGLOBIN SC DISEASE, HEMOGLOBIN C DISEASE, SICKLE CELL TRAIT, THALASSEMIA1 Jan 20081 Jan 2009
Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron OverloadNovartis PharmaceuticalsMyelodysplastic Syndromes, beta-Thalassemia, Iron Overload, Iron Chelating Agents, deferasirox1 Dec 20071 Jul 2011
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron OverloadNovartis Pharmaceuticalsiron overload, cardiac iron, haemosiderosis, myocardial T2*, left ventricular ejection fraction, LVEF, cardiac dysfunction, thalassaemia, Diamond Blackfan anemia, DBA, sideroblastic anemia, myelodysplastic syndromes, MDS (low and INT-1 risk as per the IPSS for MDS), liver MRI, deferasirox, deferoxamine, ICL670, DFO, cardiovascular magnetic resonance imaging1 Nov 20071 Mar 2013
Blood Sampling for Research Related to Sickle Cell DiseaseNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sickle Hemoglobin, Erythrocytes, Drug Screen, Sickle Cell Trait, Sickle Cell Disease1 Oct 2007
Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell ThalassemiaHaEmek Medical Center, IsraelSickle Cell Anemia, Sickle Cell Thalassemia, Iron Overload, MRI1 Sep 20071 Dec 2010
Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron OverloadNovartis Pharmaceuticalsβ-thalassemia, transfusional iron overload, renal function, renal biomarkers, deferasirox1 Sep 20071 Sep 2012
Combo Chelation TrialChildren's Hospital & Research Center OaklandThalassemia, Chelation, Iron Overload, Thalassemia patients with Iron overload1 Sep 20071 Oct 2012
Retroviral Vector Mediated Globin Gene Transfer to Correct Sickle Cell Anemia or ThalassemiaSt. Jude Children's Research Hospital1 Jul 20071 Jul 2016
Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia PatientsChina Medical University Hospital1 Jul 20071 Jul 2008
Combination Therapy of Hydroxyurea With L-Carnitine and Magnesium Chloride in Thalassemia IntermediaShiraz University of Medical SciencesHydroxyurea, magnesium chloride, L-carnitine, β-thalassemia intermedia1 Jun 20071 Dec 2007
Evaluating People With Thalassemia: The Thalassemia Longitudinal Cohort (TLC) StudyNew England Research Institutes1 May 20071 Jun 2011
Endocrine and Nutritional Assessment in B Thalassemia MajorHaEmek Medical Center, IsraelThalassemia, Nutrition, Endocrine, BMI1 May 20071 Dec 2009
Pegasys® Plus Ribavirin in Thalassemic Patients With Hepatitis C Virus InfectionBaqiyatallah Medical Sciences UniversityHepatitis C, Thalassemia, Pegasys, Ribavirin1 May 20071 Sep 2009
Long Term Follow up in Sickle Cell Patients Treated by HydroxyureaHaEmek Medical Center, IsraelSickle cell anemia, Sickle cell thalassemia, Hydroxyurea1 May 20071 Dec 2008
A Single-arm Safety Study of Transplantation Using Umbilical Cord Blood and Human Placental-derived Stem Cells From Partially Matched Related Donors in Persons With Certain Malignant Blood Diseases and Non-malignant DisordersCelgene CorporationMyelodysplastic Syndrome (MDS), Acute myelogenous Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Sickle Cell Disease (SCD), Beta Thalassemia, Inborn Errors of Metabolism, Severe Combined Immunodeficiency Disease (SCID)1 May 20071 Dec 2013
Sickle Cell Anemia in an Arab Bedouin Village in the Northern IsraelHaEmek Medical Center, IsraelSickle cell disease, Sickle cell thalassemia, Population screening1 May 20071 Dec 2008
Detection of β Thalassemia Carriers by Red Cell Parameters Obtained From the H2 Automatic CounterHaEmek Medical Center, IsraelThalassemia, Iron Deficiency, Carrier screening1 Mar 20071 Jun 2007
T2* in Transfusion Dependant Anemia, MI, LVF, Normal PatientsImperial College London1 Jan 20071 Aug 2007
Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell DiseaseSt. Jude Children's Research HospitalSickle Cell Disease, Vaso-occlusive Event, Painful Crises, Acute Chest Syndrome1 Jan 20071 Aug 2009
Autologous Bone Marrow Stem Cell Transplantation for Hip Osteonecrosis in Sickle Cell DiseaseFederal University of BahiaCell therapy, Sickle cell disease, Hip Osteonecrosis, Autologous implantation, Mesenchymal stromal cell1 Aug 20061 Aug 2015
Autologous Bone Marrow Stem Cells for Chronic Leg Ulcer Treatment in Sickle Cell DiseaseFederal University of BahiaCell Therapy, Sickle cell disease, Autologous implantation, Mesenchymal stromal cell, Edothelial Progenitor cell1 Aug 20061 Aug 2016
Evaluating the Safety of G-CSF Mobilization in Individuals With Beta Thalassemia MajorUniversity of WashingtonBeta Thalassemia Major, Hematopoietic Stem Cell Mobilization, Gene Transfer Techniques1 Jul 20061 Aug 2010
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary HypertensionNational Heart, Lung, and Blood Institute (NHLBI)Nitric Oxide, PDE Inhibitors, Pulmonary Hypertension, Sickle Cell, Thalassemia, Sickle Cell Anemia1 Jul 20061 Mar 2010
Efficacy and Safety of Deferasirox in Patients With Transfusion-Dependent Iron OverloadNovartis PharmaceuticalsThalassemia, Myelodysplastic Syndrome, MDS, Sickle cell, Diamond-Blackfan anemia, Transfusion, Anemia, Fanconi, Chelation, Deferasirox1 Jul 20061 May 2009
The Change of Coagulation Markers in Children With β-Thalassemia Disease After Stem Cell TransplantationMahidol UniversityCoagulation markers, thalassemia disease post SCT1 Jun 20061 Dec 2009
Zinc & Bone Health in Thalassemia: The Think Zinc StudyChildren's Hospital & Research Center Oaklandzinc, thalassemia, bone mineral density1 Apr 20061 Feb 2011
Compassionate Use of Deferiprone for Patients With Thalassemia and Iron-Induced Heart DiseaseChildren's Hospital of PhiladelphiaIron overload, Thalassemia, Iron induced heart disease, deferoxamine (Desferal), Deferiprone1 Mar 2006
Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGRObstetrix Medical GroupNIH, Severe Symmetrical IUGR, Tandem Mass Spectrometry, Nonimmune Hydrops, Severe Symmetrical Intrauterine Growth Restriction1 Mar 20061 Aug 2009
Cardiac T2* in Beta-thalassemia Patients on Deferasirox TreatmentNovartisIron Chelation, Deferasirox, Chelator, Desferal, beta-thalassemia, Iron overload1 Feb 20061 Nov 2009
Invasive Infections in Children With HemoglobinopathiesHaEmek Medical Center, IsraelThalassemia, Sickle cell anemia, Splenectomy, Infections, Streptococcal Pneumonia1 Jan 20061 Jun 2006
Collection of Blood From Persons With Hemoglobin and Erythrocyte Polymorphisms for Laboratory Malaria ResearchNational Institute of Allergy and Infectious Diseases (NIAID)Sickle, Hemoglobinopathy, Thalassemia, G6PD, Plasmodium, Erythrocyte Variant, Hemoglobin Variant, Healthy Volunteer, HV1 Jan 20061 Jul 2010
Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron OverloadNovartis PharmaceuticalsDeferasirox, Congenital Anemias, Anemias, Red Blood Cell Disorders, Chronic Iron Overload, Transfusional Iron Overload, Iron Chelators, Oral Iron Chelators, Thalassemia, Sickle Cell Disease, Diamond Blackfan Anemia, Myelofibrosis, ICL670A1 Oct 20051 Oct 2008
Examination of Protective Factors Against Severe MalariaNational Institute of Allergy and Infectious Diseases (NIAID)Sickle Trait, Fetal Hemoglobin, Hemoglobin C, Beta-Thalassemia, Artesunate-Amodiaquine1 Aug 20051 Apr 2009
Factors Promoting Increased Rate and Success of Pregnancy in the Thalassemia Population in TorontoUniversity Health Network, Toronto1 Jul 2005
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOPBaylor College of MedicineSickle Cell Disease, SCD, Hemoglobin SS, Hemoglobin SC, Hemoglobin Sb0/+, HLA genotype, Severe anemia, Transfusion therapy1 Jul 20051 Jul 2015
Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)Novartis PharmaceuticalsTransfusional hemosiderosis, Beta-thalassemia major, Deferasirox, iron overload, rare anemia, iron overload due to transfusion1 Jun 20051 May 2008
Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac DiseasesNational Heart, Lung, and Blood Institute (NHLBI)1 Jun 20051 Apr 2009
Heart Disease in Sickle Cell AnemiaNational Institutes of Health Clinical Center (CC)Cardiac Arrhythmias, Diastolic Dysfunction, Pulmonary Hypertension, Sickle Cell Anemia, Sudden Death, Thalassemia1 Jun 20051 Oct 2007
A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-dependent Iron OverloadNovartis PharmaceuticalsThalassemia, Myelodysplastic Syndrome, MDS, Sickle cell, Diamond-Blackfan anemia, Transfusion, Anemia, Fanconi, Chelation, Deferasirox1 Apr 20051 Jun 2010
Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-dependent PatientsLipomedDeferiprone, L1, Desferrioxamine, Hemochromatosis, Iron overload, Thalassemia1 Mar 20051 May 2011
Aspirin Prophylaxis in Sickle Cell DiseaseUniversity of Rochestersickle cell disease, hemoglobin SS disease, hemoglobin S Beta-0 Thalassemia, silent infarction in sickle cell disease, overt stroke in sickle cell disease, aspirin, transcranial Doppler ultrasound, neurocognitive testing1 Mar 20051 Nov 2009
Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or ThalassemiaNational Institute of Allergy and Infectious Diseases (NIAID)1 Jan 20051 Dec 2005
An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron OverloadNovartis Pharmaceuticalsβ-thalassemia, iron overload, deferasirox1 Oct 20041 Apr 2008
Genetic Factors Affecting the Severity of Beta ThalassemiaHadassah Medical Organization1 Jul 20041 Apr 2012
A Study of Long-term Treatment With Deferasirox in Patients With Beta-thalassemia and Transfusional HemosiderosisNovartisThalassemia (beta-thal. major), Transfusional hemosiderosis, Deferasirox, Beta-thalassemia major patients, Unable to be chelated with deferoxamine or deferiprone1 May 20041 Nov 2006
Combined Chelation Treatment With Deferiprone and Deferoxamine in Thalassemia MajorRoyal Brompton & Harefield NHS Foundation TrustRandomized Controlled Trial, Deferiprone, Deferoxamine, Iron chelation, Beta Thalassemia Major1 May 20041 Jun 2005
Monitoring of Erythroid Lineage Specific Chimerism Following Allogeneic Hematopoietic Transplantation for Thalassemia MajorDana-Farber Cancer Institutechimerism, allogenic hematopoietic transplantation, assay1 Apr 20041 Oct 2005
Genetics of Alpha Thalassemia in Israeli Ethnic GroupsHadassah Medical Organization1 Apr 20041 Apr 2012
Natural History of Sickle Cell Disease and Other Hemolytic DisordersNational Heart, Lung, and Blood Institute (NHLBI)Acute Chest Syndrome, Hemoglobin, Nitric Oxide, Pulmonary Hypertension, Pain Crisis, Treatment Options, Sickle Cell Disease, Sickle Cell Trait, Red Blood Cell Disorder, Thalassemia, Paroxysmal Nocturnal Hemoglobinuria, Hemolytic Disorders1 Apr 2004
L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 ThalassemiaEmmaus Medical, Inc.sickle cell disease, sickle cell anemia, L-glutamine, Sickle Cell Anemia (homozygous), Sickle ß0-Thalassemia1 Mar 20041 Jul 2008
Evaluation of Efficacy of Zoledronic Acid in Patients With Haemoglobin Syndromes (Thalassemia and Sicle Cell Anaemia) and Risk of Skeletal EventsNovartis Pharmaceuticalsthalassemia, zoledronic acid, skeletal events1 Mar 20041 Mar 2006
Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With HemoglobinopathiesDana-Farber Cancer InstituteHemoglobinopathies, Sickle cell anemia, sickle cell-hemoglobin C disease, sickle cell-B-thalassemia, transfusion-dependant thalassemia, allogeneic transplant, nonmyeloablative transplant, Stem cell transfusion, graft vs. host disease1 Mar 20041 Jul 2009
Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia PatientsNovartis Pharmaceuticalsβ-thalassemia, rare chronic anemia, iron overload, deferasirox, chronic anemias, transfusional hemosiderosis1 Mar 20041 Oct 2008
Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLOBaylor College of Medicinetransfusion-dependent, homozygous b0/+-thalassemia, severe variants of b0/+-thalassemia, chronic transfusion therapy, iron chelating agents, severe, transfusion-dependent homozygous b0/+-thalassemia or severe variants of b0/+-thalassemia1 Feb 20041 Sep 2015
Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TIEnte Ospedaliero Ospedali GallieraThalassemia, Neridronate, Osteopenia, Osteoporosis1 Jan 20041 May 2010
Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-ThalassemiaGenzymeBeta Thalassemia1 Sep 2003
A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.Novartis Pharmaceuticalsβ-thalassemia major, iron overload, deferasirox, pediatric rare anemia1 Sep 20031 Feb 2008
A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot StudyNational Heart, Lung, and Blood Institute (NHLBI)Sickle Cell Disease, Sickle Cell, Memory, Learning, Achievement1 Sep 20031 Dec 2012
A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe ToxicityNovartis PharmaceuticalsDeferasirox, ICL670A, Iron chelators, Deferiprone, Transfusional hemosiderosis, Congenital aplastic anemia (Diamond Blackfan anemia), Red cell aplasia, Thalassemia, β thalassemia1 Jun 20031 Dec 2007
Safety & Efficacy of ICL670 vs. Deferoxamine in Beta-thalassemia Patients With Iron Overload Due to Blood TransfusionsNovartis PharmaceuticalsThalassemia, iron overload, deferoxamine, hemosiderosis1 May 20031 Nov 2004
Evaluating the Safety of Two Medications to Treat Hepatitis C in People With Thalassemia (The HepC Study)National Heart, Lung, and Blood Institute (NHLBI)1 May 20031 Aug 2006
Study of Deferasirox in Iron Overload From Beta-thalassemia Unable to be Treated With Deferoxamine or Chronic AnemiasNovartis Pharmaceuticalsbeta-thalassemia, iron overload, deferoxamine, Myelodysplastic Syndromes, Fanconi Syndrome, Anemia, Diamond-Blackfan, Anemia, Aplastic1 May 20031 Nov 2004
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital AnemiasNational Heart, Lung, and Blood Institute (NHLBI)Stem Cell Transplant, Low Dose Radiation, Alemtuzumab (Campath), Sirolimus (Rapamune), Donor Apheresis, Graft-Versus-Host Disease, Graft-Versus-Marrow, Host-Donor Chimerism, Peripheral Blood Stem Cells, Low Dose Irradiation, Sickle Cell Anemia, SCA, Thalassemia, Diamond-Blackfan Anemia, DBA1 May 20031 Feb 2018
Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension StudyNovartis Pharmaceuticalsiron overload, iron chelation therapy, B-thalassemia1 Feb 20031 Jan 2008
L-Glutamine Therapy for Sickle Cell AnemiaLos Angeles Biomedical Research Institutesickle cell disease, sickle cell anemia, L-glutamine, Sickle Cell Anemia (homozygous and heterozygous), Sickle ß0-Thalassemia1 Jan 20031 Nov 2009
Efficacy Study in Removing Excess Iron From the HeartApoPharmaIron Overload, Thalassemia, Haemosiderosis, Cardiac, Deferiprone, Chelation1 Dec 20021 Oct 2004
A Pilot Study of HSCT for Patients With High-Risk Hemoglobinopathy Using a Nonmyeloablative Preparative RegimenUniversity of PittsburghSickle Cell Disease, Thalassemia, Hemoglobinopathies1 Jun 20021 Dec 2012
Stem Cell Transplant for HemoglobinopathyMasonic Cancer Center, University of Minnesotahigh risk hemoglobinopathy, stem cell transplant, donor lymphocyte infusion, transfusion dependent, stem cell donor, cord blood, marrow, transfusion dependent non-malignant hematologic disorders1 Jun 20021 Jun 2016
Study With Deferiprone and/or Desferrioxamine in Iron Overloaded PatientsLipomedDeferiprone, L1, Desferrioxamine, Hemochromatosis, Iron overload, Thalassemia1 Jan 2002
Stem Cell Transplant in Sickle Cell Disease and ThalassemiaColumbia Universitystem cell transplant, sickle cell disease, thalassemia, moderately ablative, cord blood transplant, matched family donor1 Dec 20011 Jan 2014
Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia MajorOspedale Microcitemico1 Dec 20011 Jun 2006
Oral Magnesium Pidolate, Hemoglobin SC Disease, MG PidolateBaylor College of MedicineHemoglobin SC disease, sickle cell-hemoglobin1 Jan 20011 May 2006
Phase II Study of Azacitidine and Phenylbutyrate in Patients With Thalassemia MajorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)genetic diseases and dysmorphic syndromes, hematologic disorders, rare disease, thalassemia major1 Nov 2000
Efficacy Study of the Use of Sequential DFP-DFO Versus DFPAzienda Ospedaliera V. Cervellothalassemia major, chelation treatment, secondary hemochromatosis1 Sep 20001 Jan 2008
Arginine Therapy in Sickle Cell Disease-VOC Clinical TrialChildren's Hospital & Research Center Oaklandsickle cell disease, vaso-occlusive pain episodes, arginine, nitric oxide1 Sep 20001 Jun 2007
Bone Marrow Transplant From Related Donor for Patients With High Risk HemoglobinopathiesBaylor College of Medicine1 Aug 2000
Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk HemoglobinopathiesBaylor College of Medicine1 Aug 2000
Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)National Heart, Lung, and Blood Institute (NHLBI)chelator, iron, transfusion, anemia, thalassemia1 Jul 20001 Jul 2006
5-Azacytidine and Phenylbutyrate to Treat Severe ThalassemiaNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Fetal Hemoglobin, 5-Azacytidine, Phenylbutyrate, Thalassemia, Hemoglobin, Anemia, Blood, Thalassemia Major, Beta Thalassemia1 Jun 20001 Jun 2003
Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic DisordersFairview University Medical Centerchronic congenital neutropenia, chronic neutropenia, congenital pure red cell aplasia, disease-related problem/condition, genetic diseases and dysmorphic syndromes, hematologic disorders, neutropenia, pure red cell aplasia, rare disease, sickle cell anemia, thalassemia major1 Jun 2000
A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling DisordersNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Fetal Hemoglobin, Hematopoietic Growth Factor, Peripheral Blood CD34 Cells, Vasoocclusive Crisis, Sickle Cell Anemia, Sickle Cell Disease, Sickle Cell Disorder1 Mar 20001 Oct 2000
Mobilization and Handling of Stem Cells for Transplant From Healthy Volunteers With Sickle Cell TraitNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Donor Apheresis, Sickle Cell Trait, Red Cell Alloimmunization1 Jan 20001 Jul 2002
Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Gamma Gene, Hemoglobin Switching, Erythropoiesis, HbE Hemoglobin Chain Synthesis Imbalance, Cooley's Anemia, Beta-Thalassemia Intermedia1 Dec 19991 Feb 2002
Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia IntermediaBoston Universitygenetic diseases and dysmorphic syndromes, hematologic disorders, rare disease, thalassemia intermedia1 Mar 1999
Cord Blood Transplantation for Sickle Cell Anemia and ThalassemiaNational Heart, Lung, and Blood Institute (NHLBI)1 Jan 19991 Aug 2006
Combination Iron Chelation TherapyNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)chelation therapy, combination chemotherapy, iron poisoning, thalassemia, chelating agent, deferoxamine, drug screening /evaluation, therapy evaluation1 Dec 19981 Nov 2002
Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia MajorNational Center for Research Resources (NCRR)disease-related problem/condition, genetic diseases and dysmorphic syndromes, hematologic disorders, osteoporosis, rare disease, thalassemia major1 Jun 19981 Aug 2000
Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell UlcersFDA Office of Orphan Products Developmentdermatologic disorders, genetic diseases and dysmorphic syndromes, hematologic disorders, rare disease, sickle cell anemia, skin ulcers, thalassemia major1 Sep 1997
Stem Cell Transplantation (SCT) for Genetic DiseasesNational Center for Research Resources (NCRR)Fanconi's anemia, amegakaryocytic thrombocytopenia, aplastic anemia, congenital pure red cell aplasia, genetic diseases and dysmorphic syndromes, hematologic disorders, inborn errors of metabolism, metachromatic leukodystrophy, pure red cell aplasia, rare disease, sphingolipidoses, thalassemia major1 Jan 1995
Allogeneic Bone Marrow Transplantation for the Treatment of Genetic Disorders of ErythropoiesisMemorial Sloan-Kettering Cancer CenterERYTHROPOIESIS, Genetic Disorders, Sickle Cell Anemia, Thalassemia, Diamond Blackfan Anemia1 Jan 19941 Aug 2008
Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl HydrazoneNational Heart, Lung, and Blood Institute (NHLBI)1 Jun 1989
Deferoxamine for the Treatment of HemochromatosisNational Heart, Lung, and Blood Institute (NHLBI)Desferal, Thalassemia, Liver Iron Concentration, Endocrine Evaluation, Diabetes Mellitus, Cardiac Disease, Acquired Anemia1 Apr 1985
Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional HemochromatosisNational Heart, Lung, and Blood Institute (NHLBI)1 Jan 1978
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood TransplantsJoanne KurtzbergHaploidentical Donor, T-cell depleted Stem Cells, Allogeneic Transplant, Umbilical Cord Blood Donor, High Risk Malignancies, Metabolic Disorders, Immune Deficiency, Acute Lympoblastic Leukemia, Acute Myelogenous Leukemia, Myelodysplastic Syndrome, ALL, AML, MDS, CGD, SCID, Adrenoleukodystrophy, Metachromaticleukodystrophy, Krabbe, PMD, Hunter's, Hurler's, Severe Aplastic Anemia, Lymphoma, Sickle Cell Disease, Thalassemia
A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell DiseaseSuvankar Majumdar