Clinical Trials

Title Sponsor Keywords Start Date Completion Date
Community Health Workers and mHealth for Sickle Cell Disease CareChildren's Hospital of Philadelphia1 Nov 201830 Nov 2022
Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease PatientsNovartis Pharmaceuticals30 Aug 201831 Mar 2022
Vitamin D Supplementation in Children With Sickle Cell DiseaseSt. Justine's Hospital1 May 201831 Jul 2019
Hydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy TrialColumbia University1 May 20181 Jun 2021
Complications in Children With B- Thalassemia MajorAssiut University1 May 20181 Oct 2019
Fetal Birth Defects: Toward a Precision-based ApproachUniversity of California, San Francisco1 Apr 20181 Dec 2025
Hyperbaric Oxygen Therapy in Sickle Cell PainUniversity of Nebraska1 Mar 20181 Mar 2019
A Study to Assess the Safety, Tolerability, and Efficacy of ST-400 for Treatment of Transfusion-Dependent Beta-thalassemia (TDT)Sangamo Therapeutics1 Mar 20181 May 2022
Shared-Decision Making for HydroxyureaChildren's Hospital Medical Center, Cincinnati1 Mar 201830 Nov 2020
Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell TransplantUniversity of Michigan1 Mar 20181 Mar 2023
Stem Cell Transplant in Patients With Severe Sickle Cell DiseaseKathleen Dorritie15 Feb 201815 Feb 2023
Risk Factors for Allo-immunization in Sickle Cell DiseaseHanane EL KENZ1 Feb 20181 Dec 2018
Transfusion in Sickle Cell Disease: Risk Factors for AlloimmunizationHanane EL KENZ1 Feb 20181 Jan 2020
Transfusion in Sickle Cell Disease: Screening of Sickle Cell Disease Trait in Blood DonorsHanane EL KENZ1 Feb 20181 Jan 2020
Predictors and Outcomes in Patients With Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Feb 20181 Feb 2022
HRV-B for Symptom Management in Sickle Cell PatientsGreenville Health System22 Jan 20181 Oct 2018
iCanCope With Sickle Cell PainSeattle Children's Hospital1 Jan 20181 Dec 2022
A Phase - IIa - IIb, Open Label Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCDHaEmek Medical Center, Israel1 Jan 201830 Jun 2020
Efficacy and Safety of RBCs Derived From Mirasol-treated Whole Blood in Patients Requiring Chronic Transfusion (PRAISE)Terumo BCTbio1 Jan 20181 Jun 2020
A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-ThalassemiaCelgene1 Jan 20181 Feb 2020
A Study of IMR-687 in Adult Patients With Sickle Cell Anaemia (Homozygous HbSS or Sickle-β0 Thalassemia)Imara, Inc.1 Jan 20181 Jun 2019
Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)Duke University1 Jan 20181 Jul 2018
Ketamine for Acute Painful Crisis in Sickle Cell Disease PatientsDammam University1 Jan 201827 Feb 2019
A Study of the Effect of IW-1701, a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)Ironwood Pharmaceuticals, Inc.1 Dec 20171 Jul 2019
Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Dec 20171 Dec 2020
Quality of Life and Treatment Satisfaction in β-Thalassemia Patients Receiving DeferasiroxAssiut University1 Dec 20171 Mar 2020
Study on the Mechanism of Colla Corri Asini in the Treatment of Thalassemia Patients With Pregnancy AnemiaThe First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine1 Dec 201728 Feb 2019
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood CancerRoswell Park Cancer Institute20 Nov 20176 Sep 2022
Non-Myeloablative Conditioning Regimen With Haploidentical T-Cell-Depleted Peripheral Blood Transplant for Patients With Severe Sickle Cell DiseaseCity of Hope Medical Center1 Nov 20171 Nov 2021
Re-Aiming at Hydroxyurea Adherence for Sickle Cell With mHealthSt. Jude Children's Research Hospital1 Nov 20171 Nov 2021
A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent Beta-ThalassemiaHoffmann-La Roche30 Oct 20171 May 2018
Sickle Cell Disease: Targeting Alloantibody Formation Reduction; Risk Factors, and GeneticsSanquin Research & Blood Bank Divisions8 Oct 201731 Dec 2019
Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)Duke University1 Oct 20171 Oct 2019
Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell DiseaseCity of Hope Medical Center1 Oct 20171 Aug 2022
Gene Transfer for Sickle Cell DiseaseDavid Williams1 Oct 20171 Oct 2024
Muscle Function and Its Biological and Physiological Determinants in Sickle Cell DiseaseHospices Civils de Lyon30 Sep 201730 Sep 2019
Gene Therapy for Beta-Thalassemia Major Using Autologous Hematopoietic Stem Cell Genetically ModifiedNanfang Hospital of Southern Medical University15 Sep 201715 Sep 2021
iCanCope With Sickle Cell Disease: a Computerized Cognitive Behavioral Therapy Program for Pain ManagementUniversity of Pittsburgh1 Sep 20171 Sep 2019
Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia PatientsAsmaa Nady Hussein1 Sep 20171 Mar 2020
HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell DiseaseCentre Hospitalier Intercommunal Creteil1 Sep 20171 Sep 2020
sPLA2 in EBC During Acute Chest SyndromeVirginia Commonwealth University1 Sep 201728 Feb 2018
Haploidentical Bone Marrow Transplantation in Sickle Cell PatientsMedical College of Wisconsin1 Sep 20171 Dec 2024
Kidney Function in Sickle Cell AnemiaUniversity of North Carolina, Chapel Hill1 Sep 201731 Aug 2022
Mesenchymal Stromal Cells for Haplo Hematopoietic Cell Transplantation for Sickle Cell DiseaseEmory University1 Sep 20171 Sep 2021
A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCTPhoenix Children's Hospital1 Aug 20171 Oct 2018
Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) PatientsNational Heart, Lung, and Blood Institute (NHLBI)25 Jul 201728 Feb 2027
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling DonorUniversity of Calgary5 Jul 20171 Jul 2023
Laboratory-based Hypnosis Intervention on Pain Responsivity in Adolescents With Sickle Cell Disease and Healthy ControlsUniversity of California, Los Angeles1 Jul 20171 Jun 2020
BEATS 2: Music Therapy in Sickle CellUniversity Hospitals Cleveland Medical Center26 Jun 201731 Dec 2018
An Open Label Randomized Controlled Trial to Evaluate the Efficacy and Safety of HYDROXYUREA in Management of Beta Thalassemia Patients in Karachi PakistanDr.Saqib Hussain Ansari13 Jun 201730 Jan 2018
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Healthy VolunteersIonis Pharmaceuticals, Inc.6 Jun 201731 Mar 2018
Erythrocyte Glutamine/Glutamate Ratio Relation to Pulmonary Hypertension Risk in Thalassemic ChildrenAssiut University1 Jun 20171 Jun 2018
Sleep and Pain in Sickle Cell DiseaseJohns Hopkins University1 Jun 201730 May 2021
Evaluation of Nutritional Status in Thalassemia Major Patients in Assiut Children HospitalAssiut University1 Jun 20171 Dec 2018
Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical CareNational Human Genome Research Institute (NHGRI)1 Jun 201730 Jun 2018
A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Subjects With Transfusion-Dependent β-Thalassemia, Who Have a β0/β0 Genotypebluebird bio1 Jun 20171 Apr 2021
A Study to Compare if the Uptake of Ticagrelor in the Body Differs When Different Tablets Are Administered.AstraZeneca4 May 20173 Jul 2017
The Effective and Safety of Thalidomide in TIXiao-Lin Yin2 May 20172 May 2019
A Study to Evaluate Safety, Pharmacokinetic, and Biological Activity of INCB059872 in Subjects With Sickle Cell DiseaseIncyte Corporation1 May 20171 Jun 2017
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell DiseaseUniversity of Illinois at Chicago28 Apr 201728 Oct 2026
Denosumab Versus Zoledronic Acid in Thalassemia-Induced OsteoporosisHamad Medical Corporation1 Apr 20171 Apr 2018
EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine TransfusionsSanquin-LUMC J.J van Rood Center for Clinical Transfusion Research1 Apr 20171 Aug 2020
Evaluation of Knowledge Among Adolescents With Sickle Cell Disease.Adele CARLIER-GONOD10 Mar 20171 Mar 2018
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)8 Mar 201731 Aug 2026
Sofosbuvir/Ledipasvir for Hepatitis C Genotype 1-6 in Patients With Transfusion-Dependent Thalassemia: An Open Label TrialAla'a Sharara15 Feb 201715 Aug 2017
In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)University of California, San Francisco1 Feb 20171 Feb 2024
Hydroxyurea Management in Kids: Intensive Versus Stable Dosage StrategiesSt. Jude Children's Research Hospital1 Feb 20171 Jun 2020
New Hemolysis Parameters in Sickle Cell DiseaseQueen Fabiola Children's University Hospital1 Feb 201727 Feb 2019
Pathophysiology of Acute Pain in Patients With Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)31 Jan 201731 Oct 2021
Gaming Technology to Engage Adolescent Sickle Cell Patients in Pain ManagementKlein Buendel, Inc.15 Jan 201730 Sep 2017
Omega-3 Fatty Acids in Sickle Cell DiseaseRobin E. Miller1 Jan 20171 Apr 2019
Dose-Finding Study of SC411 in Children With Sickle Cell DiseaseSancilio and Company, Inc.1 Jan 20171 Jul 2017
A Pilot Study of Fecal Microbiome and Neutrophil Cellular Adhesion Molecules in Patients With Sickle Cell Disease (SCD)Rhode Island Hospital1 Jan 20171 Dec 2017
A Phase Ib Study of NVX-508 in Sickle Cell DiseaseAmma Owusu-Ansah, MD1 Jan 20171 Dec 2017
Sickle-cell Disease Registry of the GPOHUniversity Hospital Heidelberg15 Dec 201631 Dec 2040
A Study of EPEG in Beta Thalassemia PatientsProlong Pharmaceuticals1 Dec 20161 Jun 2017
Precision Medical Research of Non-immune Fetal Hydrops (NIFH)-From Prenatal Diagnosis to Intrauterine TreatmentShanghai First Maternity and Infant Hospital1 Dec 20161 Aug 2018
The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia MajorCairo University1 Dec 20161 May 2018
Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell Disease Pilot and Feasibility Trial of Plerixafor for Hematopoietic Stem Cell (HSC) Mobilization in Patients With Sickle Cell DiseaseAlessandra Biffi1 Dec 20161 Jan 2018
Study to Evaluate the Effect of GBT440 Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE)Global Blood Therapeutics1 Dec 20161 Jun 2019
Fetal Hemoglobin Induction Treatment MetforminBaylor College of Medicine1 Nov 20161 Nov 2022
A Study of IMR-687 in Healthy Adult VolunteersImara, Inc.1 Nov 20161 Jun 2017
SCD-PROMIS: A Software Platform to Enhance Self-efficacy and Patient-provider Engagement for Patients With Sickle Cell PainChildren's Research Institute1 Nov 20161 Sep 2018
Hydoxyurea Exposure in Lactation: A Pharmacokinetics Study (HELPS)Children's Hospital Medical Center, Cincinnati1 Oct 20161 Nov 2019
Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization.Francis Corazza1 Oct 20161 Oct 2018
Oxygen Therapy and Pregnancy in Sickle Cell DiseaseAssistance Publique - Hôpitaux de Paris1 Sep 20161 Jun 2021
Mobile-Directly Observed Therapy on Adherence to HydroxyureaMuhimbili University of Health and Allied Sciences1 Sep 20161 Aug 2017
Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell DiseaseVanderbilt University1 Sep 20161 Oct 2018
The Effective and Safety of Thalidomide in NTDTXiao-Lin Yin1 Sep 20161 Mar 2018
Patient-Empowered Mobile Technology in Hospitalized Patients: Technology Resources to Understand Pain Assessment in Patients With Pain (TRU-PAIN)Duke University1 Aug 20161 Aug 2018
Monitoring of Chimerism After Transplantation in Patients With β Thalassemia Major and the Treatment Strategies for the Reduction of ChimerismFirst Affiliated Hospital of Guangxi Medical University1 Aug 201631 Dec 2017
Extended Evaluation of Deferasirox Film-coated Tablet (FCT) FormulationNovartis Pharmaceuticals1 Jul 20161 Sep 2018
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell DiseaseGeorgia Regents University1 Jul 20161 Jul 2018
Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell DiseaseMonica Bhatia1 Jul 20161 Dec 2017
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary HypertensionTanta University1 Jul 20161 Dec 2023
Transfusion Treatment in Patients With SCDSocietà Italiana Talassemie ed Emoglobinopatie1 Jul 201631 Dec 2020
Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)Medical College of Wisconsin1 Jun 20161 Oct 2022
Benefits of Nigella Sativa in Children With Beta Thalassemia MajorTanta University1 Jun 20161 Aug 2016
Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive CrisisChildren's Hospital & Research Center Oakland1 Jun 20161 Dec 2018
Zinc Supplementation in Children With Sickle Cell Disease in Western KenyaLucas Otieno Tina, MD MSc20 May 201619 Jan 2017
Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent TransfusionsDuke University1 May 20161 Jun 2017
SACRED A Prospective Research Study to Reduce Stroke in Children With Sickle Cell AnemiaChildren's Hospital Medical Center, Cincinnati1 May 20161 Oct 2020
HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning RegimenNational Guard Health Affairs1 May 20161 Dec 2019
Identifying Barriers and Strategies to Support Self-efficacy for Medication Adherence With Text MessagingVanderbilt University1 May 20161 May 2017
Study of Hydroxyurea to Treat Sickle Cell DiseaseMersin University1 May 20161 Jul 2016
A Multi-Center Study of Riociguat in Patients With Sickle Cell DiseasesGregory J. Kato, MD1 Apr 20161 Jun 2019
A Study of SANGUINATE for the Treatment of Vaso-occlusive Crisis (VOC) in Adult Sickle Cell Disease PatientsProlong Pharmaceuticals1 Apr 20161 Sep 2017
The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENTUniversity of Florida1 Apr 20161 Apr 2018
Transplantation Using Reduced Intensity Approach for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone MarrowEmory University1 Apr 20161 Dec 2020
Improving Self-Management in Adolescents With Sickle Cell DiseaseChildren's Hospital Medical Center, Cincinnati1 Apr 20161 Apr 2018
Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell DiseaseWashington University School of Medicine1 Mar 20161 May 2020
Investigation of the Genetics of Hematologic DiseasesSt. Jude Children's Research Hospital1 Mar 20161 Aug 2026
Plasma DNA and Vascular Remodelling in Patients With Sickle Cell DiseaseADDMEDICA SASA1 Mar 20161 Sep 2018
Evaluating Thromboelastography (TEG) and ETP in Sickle AdultsGuy's and St Thomas' NHS Foundation Trust1 Mar 20161 Jun 2016
Myeloablative Conditioning and Haplo AlloSCT for Patients With Sickle Cell DiseaseNew York Medical College1 Feb 20161 Dec 2021
Screening for Alpha Thalassemia in Healthy VolunteersNational Heart, Lung, and Blood Institute (NHLBI)1 Feb 20161 Dec 2018
A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest SyndromeUniversity of Mississippi Medical Center1 Feb 20161 Dec 2017
Arginine Therapy for Sickle Cell Disease PainEmory University1 Jan 20161 Aug 2019
SANGUINATE™ in Sickle Cell Disease Associated Leg UlcerProlong Pharmaceuticals1 Jan 20161 Jan 2017
Multi-center Study of SC411 for Sickle Cell DiseaseSancilio and Company, Inc.1 Jan 20161 Dec 2017
Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell DiseaseMontefiore Medical Center1 Jan 20161 Jun 2018
Measures of Respiratory Health (MRH)The Hospital for Sick Children1 Jan 20161 Dec 2018
Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE)Baylor College of Medicine1 Dec 20151 Dec 2020
Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis CTanta University1 Dec 20151 Dec 2016
Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis CTanta University1 Dec 20151 Dec 2016
The Prevalence and Severity of HCV Infection in Thalassemia Major and Thalassemia Intermedia in Siriraj HospitalMahidol University1 Nov 20151 Feb 2017
Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain CrisesCameroon Baptist Convention Health1 Oct 20151 Feb 2017
the Potential Immunomodulatory Effects of Spirulina on Thalassemic ChildrenTanta University1 Oct 20151 Oct 2017
Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH)ADDMEDICA SASA1 Sep 20151 Jun 2016
Prevention of Vaso-occlusive Painful Crisis by Using Omega-3 Fatty Acid SupplementsSultan Qaboos University1 Sep 20151 Mar 2019
Evaluation of the Hemostatic Potential in Sickle Cell Disease PatientsBrugmann University Hospital1 Sep 20151 Sep 2017
A Single-Dose Relative Bioavailability Study Of GBT440 300 mg Capsules in Healthy SubjectsGlobal Blood Therapeutics1 Sep 20151 Feb 2016
Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy SubjectsGlobal Blood Therapeutics1 Sep 20151 Feb 2016
Comparison of Two Methods of Transfusion for Stroke Prevention in Sickle CellChattanooga-Hamilton County Hospital Authority1 Aug 20151 Jun 2017
Comparison of Patient Centered Outcomes for People With SCD in the Acute Care SettingJohns Hopkins University1 Jul 20151 Dec 2018
Safety Of Rivipansel (GMI-1070) In The Treatment Of One or More Vaso-occlusive Crises In Hospitalized Subjects With Sickle Cell DiseasePfizer1 Jul 20151 Feb 2020
Sevuparin Infusion for the Management of Acute VOC in Subjects With SCDDilaforette AB1 Jul 20151 Jun 2016
Carbon Monoxide Measurement to Screen for Sickle Cell DiseaseChildren's Hospital & Research Center Oakland1 Jul 20151 Dec 2015
Macitentan in Pulmonary Hypertension of Sickle Cell DiseaseBoston University1 Jul 20151 Dec 2016
Evaluation of Repeat Administration of Purified Poloxamer 188Mast Therapeutics, Inc.1 Jun 20151 Jun 2016
Music Therapy in Sickle Cell Transition StudyUniversity Hospital Case Medical Center1 Jun 20151 Aug 2016
Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia PatientsKevin H.M. Kuo, MD, MSc, FRCPC1 Jun 20151 Jun 2018
SMART Mobile Application Technology Utilization in the Treatment of Sickle Cell Disease Post Day Hospital DischargeDuke University1 Jun 20151 May 2017
A Study to Evaluate the Effect of Ticagrelor in Reducing the Number of Days With Pain in Patients With Sickle Cell DiseaseAstraZeneca1 Jun 20151 Jun 2016
A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male SubjectsGlobal Blood Therapeutics1 Jun 20151 Dec 2015
Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other AnemiasApoPharma1 May 20151 Oct 2018
Arginine Therapy for the Treatment of Pain in Children With Sickle Cell DiseaseEmory University1 May 20151 Jul 2019
Gene Therapy for Transfusion Dependent Beta-thalassemiaIRCCS San Raffaele1 May 20151 Aug 2019
Study of SANGUINATE™ In the Treatment of Sickle Cell Disease Patients With Vaso-Occlusive CrisisProlong Pharmaceuticals1 Apr 20151 Apr 2016
Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta ThalassemiaTanta University1 Apr 20151 Apr 2017
Mental Health Treatment in Sickle Cell DiseaseUniversity of Pittsburgh1 Mar 20151 Dec 2015
Effect of Spirulina on Liver Iron Concentration in Beta Thalassemic Children With Hepatitis CTanta University1 Mar 20151 Dec 2016
Comparing Acute Pain Management Protocols for Patients With Sickle Cell DiseaseDuke University1 Feb 20151 Sep 2016
Dose-Escalation Study of SCD-101 in Sickle Cell DiseaseInvenux, LLC1 Feb 20151 Jan 2016
Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?Ain Shams University1 Feb 20151 Dec 2017
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell DiseaseGlobal Blood Therapeutics1 Jan 20151 May 2016
Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Genotype 1 or 4 HCV Infected Adults With Sickle Cell DiseaseGilead Sciences1 Dec 20141 Mar 2016
Treatment of Hemoglobin Sickle Cell DiseaseBaylor College of Medicine1 Dec 20141 Dec 2019
PATient Navigator to rEduce ReadmissionsUniversity of Illinois at Chicago1 Oct 20141 Apr 2016
A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Oct 20141 May 2017
ACE-536 Extension Study - Beta ThalassemiaAcceleron Pharma, Inc.1 Oct 20141 Apr 2017
Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-ThalassemiaSideris Pharmaceuticals1 Oct 20141 Jul 2015
Feasibility and Efficacy of a Home-based, Computerized Cognitive Training Program in Pediatric Sickle Cell DiseaseSteven J. Hardy1 Oct 20141 Aug 2017
Vitamin D3 in Patients With Sickle Cell DiseaseIcahn School of Medicine at Mount Sinai1 Oct 20141 Dec 2017
Assessment of Tolerance of Mobilizing Peripheral Hematopoietic Stem Cells by Plerixafor in Sickle Cell PatientsAssistance Publique - Hôpitaux de Paris1 Sep 20141 Jun 2017
A Pharmacokinetic (PK) and Pharmacodynamic (PD) Dose-ranging Phase II Study of Ticagrelor Followed by a 4 Weeks Extension Phase in Paediatric Patients With Sickle Cell DiseaseAstraZeneca1 Sep 20141 Sep 2015
Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant DiseasesBellicum Pharmaceuticals1 Sep 20141 Dec 2018
Music Therapy in Sickle Cell Pain RCTUniversity Hospital Case Medical Center1 Sep 20141 Jun 2016
Decision Aid for Therapeutic Options In Sickle Cell DiseaseEmory University1 Sep 20141 Dec 2016
Denosumab vs Placebo in Patients With Thalassemia Major and OsteoporosisErsi Voskaridou1 Sep 20141 Dec 2016
A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in Severe Sickle Cell Diseasebluebird bio1 Aug 20141 Jan 2018
Haploidentical Hematopoietic Stem Cell Transplantation for Children With Sickle Cell Disease and Thalassemia Using CD34+ Positive Selected GraftsCatherine Bollard1 Aug 20141 Dec 2019
Fertility Preservation in Women Who Will be Undergoing Gonadotoxic Therapy, Hematopoietic Stem Cell Transplantation, and in Women With Sickle Cell DiseaseEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)1 Aug 20141 Aug 2019
Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell DiseaseNational Heart, Lung, and Blood Institute (NHLBI)1 Aug 20141 May 2018
Working Memory and School Readiness in Preschool-Aged Children With Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Aug 20141 Mar 2017
Study of Beet Juice for Patients With Sickle Cell AnemiaDaniel Kim-Shapiro1 Jul 20141 Apr 2015
Stem Cell Gene Therapy for Sickle Cell DiseaseDonald B. Kohn, M.D.1 Jul 20141 Apr 2018
Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Study Of PF-04447943, Co-Administered With And Without Hydroxyurea, In Subjects With Stable Sickle Cell DiseasePfizer1 Jun 20141 Apr 2015
Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia MajorAffiliated hospital of guangxi medical university,china1 Jun 20141 Dec 2018
Patient Centered Comprehensive Medication Adherence Management System in Patients With Sickle Cell DiseaseEmory University1 Jun 20141 Dec 2018
Sickle Cell Disease (SCD) Decision AidEmory University15 May 201431 Mar 2015
Phase II Study to Investigate the Benefits of an Improved Deferasirox Formulation (Film-coated Tablet)Novartis Pharmaceuticals1 May 20141 Dec 2015
Use of Mobile Technology for Intensive Training in Medication ManagementDuke University1 May 20141 May 2016
Medication Adherence in Youth With Sickle Cell Disease (SCD)St. Jude Children's Research Hospital1 May 20141 May 2015
Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg UlcersNational Human Genome Research Institute (NHGRI)1 May 20141 Apr 2016
Sickle Cell Hemoglobinopathies and Bone HealthUniversity of Connecticut Health Center1 May 20141 May 2017
Feasibility Study of Unfractionated Heparin in Acute Chest SyndromeUniversity of Pittsburgh1 Apr 20141 Apr 2016
Gum Arabic as Fetal Hemoglobin Agent in Sickle Cell AnemiaAl-Neelain University1 Apr 20141 Jan 2015
Androgen Regulation of Priapism in Sickle Cell DiseaseJohns Hopkins University1 Mar 20141 Sep 2017
Hematopoietic Stem Cell Transplant for Sickle Cell DiseaseCase Comprehensive Cancer Center1 Mar 20141 Nov 2016
Effect of Deferasirox on Endocrine Complications in Subjects With Transfusion Dependent ThalassemiaNovartis Pharmaceuticals1 Mar 20141 Mar 2018
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant FailureNational Heart, Lung, and Blood Institute (NHLBI)1 Mar 20141 Aug 2021
Sickle Cell Clinical Research and Intervention ProgramSt. Jude Children's Research Hospital1 Mar 20141 Dec 2044
Hepcidin Levels in Sickle Cell Disease (SCD)Kenneth Ataga, MD1 Mar 20141 May 2015
Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other AnemiasApoPharma1 Feb 20141 Mar 2016
Study of Efficacy and Safety of INC424 in Regularly Transfused Patients With Thalassemia.Novartis Pharmaceuticals1 Feb 20141 Feb 2016
Amlodipine for Myocardial Iron in ThalassemiaAga Khan University1 Feb 20141 May 2015
The Effect of Rivaroxaban in Sickle Cell DiseaseUniversity of North Carolina, Chapel Hill1 Feb 20141 Sep 2016
Novel Use Of Hydroxyurea in an African Region With MalariaUniversity of Minnesota - Clinical and Translational Science Institute1 Jan 20141 Jan 2017
Allograft for Sickle Cell Disease and ThalassemiaUniversity of Texas Southwestern Medical Center1 Jan 20141 Jan 2018
Reduced Intensity Conditioning in Patients Aged ≤30 With Non-Malignant Disorders Undergoing Cord Blood TransplantationUniversity of Pittsburgh1 Dec 20131 Nov 2018
Survey in a Population of Sickle Cell Disease Patients to Evaluate the Transition Between the Queen Fabiola Children Hospital and the CHU Brugmann Hospital, and the Quality of the Hospital Care Within the CHU Brugmann Hospital.Brugmann University Hospital1 Dec 20131 Dec 2016
Phase 2 Study of Montelukast for the Treatment of Sickle Cell AnemiaVanderbilt University1 Nov 20131 Oct 2017
SCD-Haplo: A Phase II Study of HLA-Haploidentical Stem Cell Transplation to Treat Clinically Aggressive Sickle Cell DiseaseDamiano Rondelli, MD1 Nov 20131 Oct 2018
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell TransplantDiane George, MD1 Nov 20131 Dec 2017
Added Value of Speckle Tracking in the Evaluation of Patients With Sickle Cell DiseaseBrugmann University Hospital1 Nov 20131 Mar 2016
Feasibility of a Stress Reduction Intervention Study in Sickle Cell DiseaseUniversity of Illinois at Chicago1 Nov 20131 Nov 2014
Ph. 2 Study of MP4CO to Treat Vaso-occlusive Sickle CrisisSangart1 Oct 20131 Oct 2015
Treatment of Iron Overload Requiring Chelation TherapyShire Development LLC1 Oct 20131 Jul 2015
Pain Management in Children and Young Adults With Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Oct 20131 Oct 2017
Evaluation of Nocturnal Enuresis and Barriers to Treatment Among Pediatric Patients With Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Oct 20131 Oct 2015
Hydroxyurea Therapy, Sickle Cell Disease, NDEPTHBaylor College of Medicine1 Oct 20131 Oct 2018
Utility of Fibroscan in Estimating Hepatic Iron ConcentrationUniversity of British Columbia1 Oct 20131 Oct 2014
Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain CrisisSt. Louis University1 Sep 20131 Sep 2015
Deferasirox BID in Transfusion Dependent Thalassemia Patients With Indadequate Response to High DosesNovartis Pharmaceuticals1 Sep 20131 Sep 2015
Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABITColumbia University1 Sep 20131 May 2015
Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in IndonesiaFakultas Kedokteran Universitas Indonesia1 Sep 20131 Feb 2014
Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell DiseaseDuke University1 Aug 20131 Feb 2020
Improving Disease Knowledge in Adolescents With Sickle Cell DiseaseThe University of The West Indies1 Aug 20131 Aug 2015
Evaluation of Sickle Cell Liver DiseaseNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Aug 20131 May 2018
Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesSelexys Pharmaceuticals Corporation1 Jul 20131 Aug 2015
An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years OldNovartis Pharmaceuticals1 Jun 20131 Oct 2014
Efficacy/Safety Study of Deferiprone Compared to Deferasirox in Paediatric PatientsConsorzio per Valutazioni Biologiche e Farmacologiche1 Jun 20131 Dec 2014
Exhaled Carbon Monoxide as a Marker of Hemolysis in Sickle Cell Disease- an Exploratory StudyUniversity Hospital Case Medical Center1 Jun 20131 Jun 2015
Nitrous Oxide Analgesia Vaso-occlusive CrisisColumbia University1 Jun 20131 Jun 2014
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell DiseaseUniversity Hospital Case Medical Center1 Jun 20131 Jun 2015
Reproductive Capacity and Iron Burden in ThalassemiaChildren's Hospital & Research Center Oakland1 Jun 20131 Jun 2016
Evaluation of the Free α-hemoglobin Pool in the Red Blood Cells : Prognostic Marker and Severity Index in Thalassemic SyndromesAssistance Publique - Hôpitaux de Paris1 Jun 20131 Jun 2016
Absorption, Metabolism, and Excretion of a Single Dose of Ferriprox® in Patients With Sickle Cell DiseaseApoPharma1 May 20131 Jul 2013
Non-Myeloablative Conditioning and Bone Marrow TransplantationVanderbilt-Ingram Cancer Center1 May 20131 May 2016
A Phase II Trial of Regadenoson in Sickle Cell AnemiaDana-Farber Cancer Institute1 Apr 20131 Apr 2015
N-Acetylcysteine in Patients With Sickle Cell DiseaseAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)1 Apr 20131 Oct 2014
A Study Evaluating the Safety and Efficacy of the Gene Therapy LentiGlobin® BB305 Drug Product in Subjects With Beta-Thalassemia MajorBluebird Bio1 Mar 20131 Jul 2017
A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)Eli Lilly and Company1 Mar 20131 Jun 2015
CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant DiseaseDiane George, MD1 Mar 20131 Mar 2017
Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD)NKT Therapeutics1 Feb 20131 Aug 2014
Sickle Cell Disease - Stroke Prevention in Nigeria TrialVanderbilt University1 Feb 20131 Aug 2014
Microvascular and Fibrosis Imaging StudyDuke University1 Jan 20131 Jan 2017
Vaporized Cannabis for Chronic Pain Associated With Sickle Cell DiseaseUniversity of California, San Francisco1 Jan 20131 Mar 2016
Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC TransfusionCerus Corporation1 Dec 20121 Jun 2014
Pharmacokinetic Study of Deferiprone in Paediatric PatientsConsorzio per Valutazioni Biologiche e Farmacologiche1 Dec 20121 Apr 2013
Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC)Adventrx Pharmaceuticals1 Dec 20121 Aug 2015
An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study)Novartis Pharmaceuticals1 Dec 20121 Jul 2014
Study of ACE-536 to Evaluate the Effects of ACE-536 in Patients With Beta-thalassemia IntermediaAcceleron Pharma, Inc.1 Dec 20121 Nov 2014
Evaluation of Spectra Optia RBC Exchange in Sickle Cell PatientsCaridianBCT1 Nov 20121 May 2013
Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood DisordersMassachusetts General Hospital1 Nov 20121 Jan 2015
Zinc and Diabetes in Patients With Thalassemia: a Pilot StudyChildren's Hospital & Research Center Oakland1 Nov 20121 Dec 2014
The Use of Warmed Saline in Vaso-occlusive EpisodesNationwide Children's Hospital1 Nov 20121 Jun 2014
Single-center Prospective Evaluation of Sickle Cell Patient Care in the CHU Brugmann Emergency DepartmentBrugmann University Hospital1 Nov 20121 May 2015
An Open Label, Multi-center, Efficacy and Safety Study of Deferasirox in Iron Overloaded Patients With Non-transfusion Dependent ThalassemiaNovartis Pharmaceuticals1 Oct 20121 Apr 2014
Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) Follow-up Observational Study II ProtocolNational Heart, Lung, and Blood Institute (NHLBI)1 Oct 20121 Dec 2016
Cognitive Rehabilitation in Sickle Cell DiseaseDuke University1 Oct 20121 Mar 2014
Carbon Monoxide Monitor for the Measurement of End-Tidal Carbon Monoxide Levels in Children With or Without HemolysisAshutosh Lal1 Oct 20121 Oct 2013
Sickle Cell Trait in Football PlayersUniversity of South Florida1 Oct 20121 Aug 2013
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient NavigatorsVirginia Commonwealth University1 Oct 20121 Aug 2016
Combination Deferasirox and Deferiprone for Severe Iron Overload in ThalassemiaChildren's Hospital of Philadelphia1 Sep 20121 Aug 2015
Unrelated Umbilical Cord Blood Following HLA-haploidentical Hematopoietic Stem Cell Transplantation in Patients With β-thalassemia MajorNanfang Hospital of Southern Medical University1 Sep 20121 Jun 2015
ß-Thalassemia Major With Autologous CD34+ Hematopoietic Progenitor Cells Transduced With TNS9.3.55 a Lentiviral Vector Encoding the Normal Human ß-Globin GeneMemorial Sloan-Kettering Cancer Center1 Jul 20121 Jul 2014
Liver Fibrosis in Sickle Cell DiseaseUniversity of Miami1 Jul 20121 Dec 2017
Post Hematopoietic Stem Cell TransplantationNovartis Pharmaceuticals1 Jun 20121 Jul 2014
Therapeutic Effect and Safety of Combined Hydroxyurea With Recombinant Human Erythropoietin.Ain Shams University1 Jun 20121 Dec 2012
Immunomodulatory Effects of Silymarin in Patients With Beta-Thalassemia MajorShiraz University of Medical Sciences1 Jun 20121 Sep 2012
Use of a Mobile-based App for SCD PatientsJude C. Jonassaint1 Jun 20121 Jun 2014
Trial of HQK-1001 in Beta Thalassemia Intermedia in LebanonBoston University1 May 20121 Jan 2013
Massive Iron Deposit AssessmentSt. Jude Children's Research Hospital1 Apr 20121 Apr 2017
Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta( β)- Thalassemia.Celgene Corporation1 Mar 20121 Jun 2014
Study of SDMB in Beta Thalassemia Intermedia in ThailandBoston University1 Mar 20121 Dec 2012
Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused PopulationsAssistance Publique - Hôpitaux de Paris1 Mar 20121 Mar 2015
Effects of Transfusion of Older Red Blood Cells on Patients With HemoglobinopathiesColumbia University1 Feb 20121 Feb 2015
Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron OverloadAin Shams University1 Feb 20121 Feb 2013
Prevalence of Pulmonary Hypertension (PAH) in Patients With ThalassemiaEnte Ospedaliero Ospedali Galliera1 Jan 20121 Jan 2013
Safety Study of MP4CO in Adult Sickle Cell PatientsSangart1 Jan 20121 Mar 2013
Effect of Metoprolol on Thalassemia CardiomyopathyShiraz University of Medical Sciences1 Jan 20121 Dec 2012
Functional Neuroimaging of Pain Using EEG and fMRIUniversity of Minnesota - Clinical and Translational Science Institute1 Jan 20121 May 2015
Demographic, Clinical, Laboratory and Genetical Characteristics of Patients With Beta Thalassemia IntermediaHaEmek Medical Center, Israel1 Oct 20111 Dec 2012
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)Center for International Blood and Marrow Transplant Research1 Oct 2011
Providing Access to Cord Blood Units for TransplantsNational Cancer Institute (NCI)1 Oct 20111 Nov 2012
Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia MajorUniversity of Campinas, Brazil1 Aug 20111 Dec 2013
Study of Effects of YisuiShengxueGranules on ThalassemiaGuang'anmen Hospital of China Academy of Chinese Medical Sciences1 Jul 20111 Jan 2012
Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron OverloadShire Development LLC1 Jul 20111 Dec 2013
The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response StudyWeill Medical College of Cornell University1 Jun 20111 Dec 2014
Stem Cell Transplantation for Sickle Cell AnemiaHackensack University Medical Center1 Jun 20111 Jun 2018
Patient-Provider Tools to Improve the Transition to Adult Care in Sickle Cell DiseaseChildren's Hospital Medical Center, Cincinnati1 Jun 20111 Jul 2015
Phase I/II Pilot Study of Mixed Chimerism to Treat HemoglobinopathiesUniversity of Louisville1 May 20111 May 2030
High-Tc Susceptometer to Monitor Transfusional Iron OverloadColumbia University1 Mar 20111 May 2014
Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood DisordersNational Heart, Lung, and Blood Institute (NHLBI)1 Mar 20111 Apr 2013
Study of Panobinostat (LBH589) in Patients With Sickle Cell DiseaseAbdullah Kutlar1 Nov 20101 Dec 2014
Evaluating the Safety and Effectiveness of Mozobil Mobilization in Adults With Beta-Thalassemia MajorUniversity of Washington1 Oct 20101 Dec 2012
A Randomized Trial of LOVAZA in Pediatric Sickle Cell Disease (SCD)Thomas Jefferson University1 Oct 20101 Mar 2012
B Memory Cell Response to Vaccination With the 13-valent Pneumococcal Conjugate Vaccine in Asplenic IndividualsAghia Sophia Children's Hospital of Athens1 Oct 20101 Feb 2012
Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationEmory University1 Sep 20101 Sep 2015
GDF 15 in Sickle Cell Disease and Hereditary SpherocytosisWolfson Medical Center1 Sep 20101 Sep 2011
Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron OverloadShire Development LLC1 Aug 20101 Jan 2013
Genes Influencing Iron Overload StateSt. Jude Children's Research Hospital1 Aug 20101 Jul 2016
Safety and Efficacy of Deferasirox in β-thalassaemia Patients With Severe Cardiac Iron OverloadNovartis Pharmaceuticals1 Jul 20101 Dec 2014
Sickle Cell Trait and the Risk of Venous ThromboembolismAlbert Einstein College of Medicine of Yeshiva University1 Jul 20101 Dec 2012
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell DiseaseUniversity of Miami1 Jun 20101 Dec 2016
A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemiaEmmaus Medical, Inc.1 May 20101 Feb 2013
Perceptions of Thalassemia Major in Singapore: An Exploratory Study of StigmaNational Human Genome Research Institute (NHGRI)1 Apr 2010
Beta-thalassemia and MicroparticlesAssistance Publique Hopitaux De Marseille1 Mar 20101 Mar 2013
Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension Study (THALASSA)Novartis Pharmaceuticals1 Mar 20101 Jun 2012
Multi-Center Study of Iron Overload: Survey Study (MCSIO)Children's Hospital & Research Center Oakland1 Mar 20101 Oct 2013
Efficacy and Safety of Desferal Versus Osveral in Transfusional Iron OverloadHormozgan University of Medical Sciences1 Feb 20101 May 2011
Reduced Intensity Transplant Conditioning Regimen for Severe ThalassemiaWashington University School of Medicine1 Jan 20101 Sep 2011
This Study Will Evaluate Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndromes (MDS), Thalassemia and Rare Anemia Types Having Transfusion-induced Iron Overload.Novartis Pharmaceuticals1 Dec 20091 Sep 2011
Zoledronic Acid for the Prevention of Bone Loss Post-bone Marrow Transplantation for Thalassemia Major PatientsTehran University of Medical Sciences1 Nov 20091 Dec 2011
Multi-Center Study of Iron Overload: Pilot StudyChildren's Hospital & Research Center Oakland1 Nov 20091 Sep 2012
Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron OverloadFerroKin BioSciences, Inc.1 Nov 20091 Dec 2010
Demographic, Clinical and Laboratory Characteristics of Children With Alpha Thalassemia in Northern IsraelHaEmek Medical Center, Israel1 Oct 20091 Dec 2010
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-ThalassemiaNational Heart, Lung, and Blood Institute (NHLBI)1 Sep 20091 Aug 2015
Assessment of Pain in People With Thalassemia Who Are Treated With Regular Blood TransfusionsNational Heart, Lung, and Blood Institute (NHLBI)1 Jul 20091 Oct 2010
Traditional Chinese Medicine in the Supportive Management of Anaemic and Cytopenic (Leukopenia, Thrombocytopenia) Haematological DisordersSingapore General Hospital1 Jul 20091 Aug 2011
Treosulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited DisordersFred Hutchinson Cancer Research Center/University of Washington Cancer Consortium1 Jul 20091 Jul 2017
Families Taking Control (FTC): Family-based Problem-solving Intervention for Children With Sickle Cell DiseaseUniversity of Pennsylvania1 Jul 20091 Aug 2012
Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E PatientsMahidol University1 Jun 20091 Jun 2011
Blood Transfusions in Thalassemia Patients, Complications and Adverse EffectsHaEmek Medical Center, Israel1 May 20091 Nov 2010
Phase 1/2 Study of HQK-1001 in Patients With Beta ThalassemiaHemaQuest Pharmaceuticals Inc.1 Mar 20091 May 2010
Sildenafil to Improve Exercise Capacity in People With Thalassemia and Pulmonary HypertensionNational Heart, Lung, and Blood Institute (NHLBI)1 Mar 20091 Nov 2010
Therapeutic Effects of Silymarin in Patients With B-thalassemia MajorIsfahan University of Medical Sciences1 Mar 20091 Dec 2009
Assessment of Pain in People With ThalassemiaNational Heart, Lung, and Blood Institute (NHLBI)1 Mar 20091 Dec 2010
Glutamine Therapy for Hemolysis-Associated Pulmonary HypertensionChildren's Hospital & Research Center Oakland1 Mar 20091 Mar 2013
Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCsStanford University1 Mar 20091 Aug 2013
The Spleen in Sickle Cell Anemia and Sickle Cell ThalassemiaHaEmek Medical Center, Israel1 Feb 20091 Aug 2010
Effect of Deferasirox on Patients With Cardiac MRI T2* < 20 MsecNovartis Pharmaceuticals1 Feb 20091 May 2011
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell AnemiaHaEmek Medical Center, Israel1 Jan 20091 Jul 2010
Interferon and Ribavirin Treatment in Patients With HemoglobinopathiesAzienda Ospedaliera V. Cervello1 Jan 20091 Dec 2013
European Sickle Cell Disease Cohort - HydroxyureaADDMEDICA SASA1 Jan 20091 Dec 2018
Fresh Versus Old Red Blood Cells for TransfusionColumbia University1 Dec 20081 Mar 2011
HSCT For Patients With High Risk Hemoglobinopathies Using Reduced IntensityNorth Shore Long Island Jewish Health System1 Dec 20081 Jan 2017
Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron OverloadNovartis Pharmaceuticals1 Nov 20081 Jun 2011
Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia MajorUniversity of Campinas, Brazil1 Sep 20081 Jul 2011
Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell ThalassemiaHaEmek Medical Center, Israel1 Sep 20081 Dec 2010
Evaluation of Non-invasive Endothelial Function in Children Sickle by Vascular UltrasoundUniversity Hospital, Toulouse1 Sep 20081 Sep 2016
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood CellsChildren's Hospital Los Angeles1 Aug 20081 Aug 2012
Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant DisordersDuke University1 Aug 20081 Dec 2013
Iron Balance Study of Deferasirox, Deferoxamine and the Combination of BothWeill Medical College of Cornell University1 Aug 20081 Dec 2009
Oral Nifedipine to Treat Iron OverloadNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Jun 20081 Sep 2010
Sickle Cell Anemia Screening and Prevention in Northern IsraelHaEmek Medical Center, Israel1 May 2008
Clinical Diagnosis of Teenagers Admitted to Pediatric DepartmentsHaEmek Medical Center, Israel1 May 2008
Clinical and Laboratory Characteristics of Sickle Cell Anemia Patients Admitted With FeverHaEmek Medical Center, Israel1 May 20081 Nov 2008
Diabetic Retinopathy and Sickle TraitMedical University of South Carolina1 May 20081 Jul 2010
Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia MajorMemorial Sloan-Kettering Cancer Center1 Apr 20081 Feb 2011
Pilot Study for Patients With Poor Response to DeferasiroxChildren's Hospital Boston1 Mar 20081 Nov 2008
Evaluating the Safety and Effectiveness of Decitabine in People With Thalassemia IntermediaNational Heart, Lung, and Blood Institute (NHLBI)1 Jan 20081 Sep 2010
MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions.Sheba Medical Center1 Jan 20081 May 2010
Far Infrared Radiation for Sickle Cell Pain ManagementGAAD Medical Research Institute Inc.1 Jan 20081 Jan 2009
Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron OverloadNovartis Pharmaceuticals1 Dec 20071 Jul 2011
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron OverloadNovartis Pharmaceuticals1 Nov 20071 Mar 2013
Blood Sampling for Research Related to Sickle Cell DiseaseNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Oct 2007
Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell ThalassemiaHaEmek Medical Center, Israel1 Sep 20071 Dec 2010
Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron OverloadNovartis Pharmaceuticals1 Sep 20071 Sep 2012
Combo Chelation TrialChildren's Hospital & Research Center Oakland1 Sep 20071 Oct 2012
Retroviral Vector Mediated Globin Gene Transfer to Correct Sickle Cell Anemia or ThalassemiaSt. Jude Children's Research Hospital1 Jul 20071 Jul 2016
Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia PatientsChina Medical University Hospital1 Jul 20071 Jul 2008
Combination Therapy of Hydroxyurea With L-Carnitine and Magnesium Chloride in Thalassemia IntermediaShiraz University of Medical Sciences1 Jun 20071 Dec 2007
Evaluating People With Thalassemia: The Thalassemia Longitudinal Cohort (TLC) StudyNew England Research Institutes1 May 20071 Jun 2011
Endocrine and Nutritional Assessment in B Thalassemia MajorHaEmek Medical Center, Israel1 May 20071 Dec 2009
Pegasys® Plus Ribavirin in Thalassemic Patients With Hepatitis C Virus InfectionBaqiyatallah Medical Sciences University1 May 20071 Sep 2009
Long Term Follow up in Sickle Cell Patients Treated by HydroxyureaHaEmek Medical Center, Israel1 May 20071 Dec 2008
A Single-arm Safety Study of Transplantation Using Umbilical Cord Blood and Human Placental-derived Stem Cells From Partially Matched Related Donors in Persons With Certain Malignant Blood Diseases and Non-malignant DisordersCelgene Corporation1 May 20071 Dec 2013
Sickle Cell Anemia in an Arab Bedouin Village in the Northern IsraelHaEmek Medical Center, Israel1 May 20071 Dec 2008
Detection of β Thalassemia Carriers by Red Cell Parameters Obtained From the H2 Automatic CounterHaEmek Medical Center, Israel1 Mar 20071 Jun 2007
T2* in Transfusion Dependant Anemia, MI, LVF, Normal PatientsImperial College London1 Jan 20071 Aug 2007
Hydroxyurea and Magnesium Pidolate to Treat People With Hemoglobin Sickle Cell DiseaseSt. Jude Children's Research Hospital1 Jan 20071 Aug 2009
Autologous Bone Marrow Stem Cell Transplantation for Hip Osteonecrosis in Sickle Cell DiseaseFederal University of Bahia1 Aug 20061 Aug 2015
Autologous Bone Marrow Stem Cells for Chronic Leg Ulcer Treatment in Sickle Cell DiseaseFederal University of Bahia1 Aug 20061 Aug 2016
Evaluating the Safety of G-CSF Mobilization in Individuals With Beta Thalassemia MajorUniversity of Washington1 Jul 20061 Aug 2010
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary HypertensionNational Heart, Lung, and Blood Institute (NHLBI)1 Jul 20061 Mar 2010
Efficacy and Safety of Deferasirox in Patients With Transfusion-Dependent Iron OverloadNovartis Pharmaceuticals1 Jul 20061 May 2009
The Change of Coagulation Markers in Children With β-Thalassemia Disease After Stem Cell TransplantationMahidol University1 Jun 20061 Dec 2009
Zinc & Bone Health in Thalassemia: The Think Zinc StudyChildren's Hospital & Research Center Oakland1 Apr 20061 Feb 2011
Compassionate Use of Deferiprone for Patients With Thalassemia and Iron-Induced Heart DiseaseChildren's Hospital of Philadelphia1 Mar 2006
Amniotic Fluid Tandem Mass Spectrometry for Pregnancies Complicated by NIH and Severe Symmetrical IUGRObstetrix Medical Group1 Mar 20061 Aug 2009
Cardiac T2* in Beta-thalassemia Patients on Deferasirox TreatmentNovartis1 Feb 20061 Nov 2009
Invasive Infections in Children With HemoglobinopathiesHaEmek Medical Center, Israel1 Jan 20061 Jun 2006
Collection of Blood From Persons With Hemoglobin and Erythrocyte Polymorphisms for Laboratory Malaria ResearchNational Institute of Allergy and Infectious Diseases (NIAID)1 Jan 20061 Jul 2010
Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron OverloadNovartis Pharmaceuticals1 Oct 20051 Oct 2008
Examination of Protective Factors Against Severe MalariaNational Institute of Allergy and Infectious Diseases (NIAID)1 Aug 20051 Apr 2009
Factors Promoting Increased Rate and Success of Pregnancy in the Thalassemia Population in TorontoUniversity Health Network, Toronto1 Jul 2005
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOPBaylor College of Medicine1 Jul 20051 Jul 2015
Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration)Novartis Pharmaceuticals1 Jun 20051 May 2008
Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac DiseasesNational Heart, Lung, and Blood Institute (NHLBI)1 Jun 20051 Apr 2009
Heart Disease in Sickle Cell AnemiaNational Institutes of Health Clinical Center (CC)1 Jun 20051 Oct 2007
A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-dependent Iron OverloadNovartis Pharmaceuticals1 Apr 20051 Jun 2010
Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-dependent PatientsLipomed1 Mar 20051 May 2011
Aspirin Prophylaxis in Sickle Cell DiseaseUniversity of Rochester1 Mar 20051 Nov 2009
Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or ThalassemiaNational Institute of Allergy and Infectious Diseases (NIAID)1 Jan 20051 Dec 2005
An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron OverloadNovartis Pharmaceuticals1 Oct 20041 Apr 2008
Genetic Factors Affecting the Severity of Beta ThalassemiaHadassah Medical Organization1 Jul 20041 Apr 2012
A Study of Long-term Treatment With Deferasirox in Patients With Beta-thalassemia and Transfusional HemosiderosisNovartis1 May 20041 Nov 2006
Combined Chelation Treatment With Deferiprone and Deferoxamine in Thalassemia MajorRoyal Brompton & Harefield NHS Foundation Trust1 May 20041 Jun 2005
Monitoring of Erythroid Lineage Specific Chimerism Following Allogeneic Hematopoietic Transplantation for Thalassemia MajorDana-Farber Cancer Institute1 Apr 20041 Oct 2005
Genetics of Alpha Thalassemia in Israeli Ethnic GroupsHadassah Medical Organization1 Apr 20041 Apr 2012
Natural History of Sickle Cell Disease and Other Hemolytic DisordersNational Heart, Lung, and Blood Institute (NHLBI)1 Apr 2004
L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 ThalassemiaEmmaus Medical, Inc.1 Mar 20041 Jul 2008
Evaluation of Efficacy of Zoledronic Acid in Patients With Haemoglobin Syndromes (Thalassemia and Sicle Cell Anaemia) and Risk of Skeletal EventsNovartis Pharmaceuticals1 Mar 20041 Mar 2006
Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With HemoglobinopathiesDana-Farber Cancer Institute1 Mar 20041 Jul 2009
Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia PatientsNovartis Pharmaceuticals1 Mar 20041 Oct 2008
Allogeneic Stem Cell Transplantation, Severe Homzygous 0/+Thalassemia or Sever Variants of Beta 0/+ Thalassemia, THALLOBaylor College of Medicine1 Feb 20041 Sep 2015
Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TIEnte Ospedaliero Ospedali Galliera1 Jan 20041 May 2010
Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-ThalassemiaGenzyme1 Sep 2003
A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload.Novartis Pharmaceuticals1 Sep 20031 Feb 2008
A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot StudyNational Heart, Lung, and Blood Institute (NHLBI)1 Sep 20031 Dec 2012
A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe ToxicityNovartis Pharmaceuticals1 Jun 20031 Dec 2007
Safety & Efficacy of ICL670 vs. Deferoxamine in Beta-thalassemia Patients With Iron Overload Due to Blood TransfusionsNovartis Pharmaceuticals1 May 20031 Nov 2004
Evaluating the Safety of Two Medications to Treat Hepatitis C in People With Thalassemia (The HepC Study)National Heart, Lung, and Blood Institute (NHLBI)1 May 20031 Aug 2006
Study of Deferasirox in Iron Overload From Beta-thalassemia Unable to be Treated With Deferoxamine or Chronic AnemiasNovartis Pharmaceuticals1 May 20031 Nov 2004
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital AnemiasNational Heart, Lung, and Blood Institute (NHLBI)1 May 20031 Feb 2018
Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension StudyNovartis Pharmaceuticals1 Feb 20031 Jan 2008
L-Glutamine Therapy for Sickle Cell AnemiaLos Angeles Biomedical Research Institute1 Jan 20031 Nov 2009
Efficacy Study in Removing Excess Iron From the HeartApoPharma1 Dec 20021 Oct 2004
A Pilot Study of HSCT for Patients With High-Risk Hemoglobinopathy Using a Nonmyeloablative Preparative RegimenUniversity of Pittsburgh1 Jun 20021 Dec 2012
Stem Cell Transplant for HemoglobinopathyMasonic Cancer Center, University of Minnesota1 Jun 20021 Jun 2016
Study With Deferiprone and/or Desferrioxamine in Iron Overloaded PatientsLipomed1 Jan 2002
Stem Cell Transplant in Sickle Cell Disease and ThalassemiaColumbia University1 Dec 20011 Jan 2014
Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia MajorOspedale Microcitemico1 Dec 20011 Jun 2006
Oral Magnesium Pidolate, Hemoglobin SC Disease, MG PidolateBaylor College of Medicine1 Jan 20011 May 2006
Phase II Study of Azacitidine and Phenylbutyrate in Patients With Thalassemia MajorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Nov 2000
Efficacy Study of the Use of Sequential DFP-DFO Versus DFPAzienda Ospedaliera V. Cervello1 Sep 20001 Jan 2008
Arginine Therapy in Sickle Cell Disease-VOC Clinical TrialChildren's Hospital & Research Center Oakland1 Sep 20001 Jun 2007
Bone Marrow Transplant From Related Donor for Patients With High Risk HemoglobinopathiesBaylor College of Medicine1 Aug 2000
Bone Marrow Transplant From Donor Using Less Toxic Conditioning for Patient With High Risk HemoglobinopathiesBaylor College of Medicine1 Aug 2000
Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)National Heart, Lung, and Blood Institute (NHLBI)1 Jul 20001 Jul 2006
5-Azacytidine and Phenylbutyrate to Treat Severe ThalassemiaNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Jun 20001 Jun 2003
Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic DisordersFairview University Medical Center1 Jun 2000
A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling DisordersNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Mar 20001 Oct 2000
Mobilization and Handling of Stem Cells for Transplant From Healthy Volunteers With Sickle Cell TraitNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Jan 20001 Jul 2002
Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Dec 19991 Feb 2002
Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia IntermediaBoston University1 Mar 1999
Cord Blood Transplantation for Sickle Cell Anemia and ThalassemiaNational Heart, Lung, and Blood Institute (NHLBI)1 Jan 19991 Aug 2006
Combination Iron Chelation TherapyNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)1 Dec 19981 Nov 2002
Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia MajorNational Center for Research Resources (NCRR)1 Jun 19981 Aug 2000
Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell UlcersFDA Office of Orphan Products Development1 Sep 1997
Stem Cell Transplantation (SCT) for Genetic DiseasesNational Center for Research Resources (NCRR)1 Jan 1995
Allogeneic Bone Marrow Transplantation for the Treatment of Genetic Disorders of ErythropoiesisMemorial Sloan-Kettering Cancer Center1 Jan 19941 Aug 2008
Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl HydrazoneNational Heart, Lung, and Blood Institute (NHLBI)1 Jun 1989
Deferoxamine for the Treatment of HemochromatosisNational Heart, Lung, and Blood Institute (NHLBI)1 Apr 1985
Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional HemochromatosisNational Heart, Lung, and Blood Institute (NHLBI)1 Jan 1978
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood TransplantsJoanne Kurtzberg
A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell DiseaseSuvankar Majumdar

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