The current SARS-CoV-2 infection [COVID-19] affects primarily the respiratory system, from nasopharyngeal symptoms to full blown pneumonia. Most of the severe and fatal COVID-19 cases seem to be associated with specific high-risk populations, including people over 65 years of age and those with compromised immune status and chronic conditions. Patients with sickle cell disease (SCD) have a weakened immune system and underlying cardiopulmonary co-morbidities that may predispose them to poor outcomes if they become infected with COVID-19. As to better understand how this new virus impacts SCD patients and to provide the best available care for the SCD community worldwide, the Secure-SCD registry has been established in the midst of the current COVID-19 pandemic to capture pediatric and adult SCD cases infected with COVID-19. Providers who care for these patients are encouraged to access the registry here and to report all their cases of COVID-19. The registry contains only de-identified data and is constantly updated to provide accurate and helpful health information and data concerning the disease.