It is believed that when androgen (testosterone) levels are below normal that there is a disturbance of normal bodily functioning that is associated with priapism in some men. Conversely, it is believed that testosterone replacement will improve the condition of priapism when the testosterone levels are brought to normal. In turn, this will also improve psychological well being in men with sickle cell disease.

This clinical trial will evaluate the efficacy of testosterone replacement therapy on the frequency of recurrent priapism in patients with SCD and will test the sub-hypothesis that T replacement to achieve serum T concentrations at a target range reduces recurrent priapism.

More information: clinicaltrials.gov, ITHANET Clinical Trials