Welcome to IthaMaps

IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.

IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge


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  General information for Mexico

Continent: North America
Capital: Mexico City
Population: 112468855
Area (in sq km): 1972550.0

Haemoglobinopathy-specific healthcare policy information for Mexico

Healthcare policyComment/InfoReference
Prevention programme: No
SCD newborn screening: No
Prenatal screening: No
Antenatal screening: No
Haemoglobinopathies patient registry: Yes (Regional)
Rare disease patient registry: No
Blood transfusion availability: Yes (National)
Iron chelation availability: Yes (National)In some haematology departments of local and national hospitals
MRI facilities: Yes (National)In some haematology departments of local and national hospitals
Patient associations: No
Genetic counselling: Yes (National)Offered by geneticists.

  Prevalence and incidence of major haemoglobinopathies in Mexico

Prevalence of β-thalassaemia carriers: 0.4 % of the population12-18% in selected populations.[PMID: 20184100]
Prevalence of sickle cell disease carriers: 1 % of the population0.4-1% in Mexican mestizos. In Mexicans with African ancestors the prevalence is 4-12.8% and in selected populations it is 4-7%.[PMID: 20184100]
Prevalence of Hb E carriers: 0 % of the populationFrom: Modell's Haemoglobinopathologist's Almanac.
Prevalence of Hb C carriers: 0.05 % of the populationFrom: Modell's Haemoglobinopathologist's Almanac.
Incidence of sickle cell disease: 641 affected births/yearMedian value estimated using statistical model and demographic data.[PMID: 23103089]

Mutation frequencies in Mexico

 Overview (most frequent mutations with their observed average values and range)


-α3.7 (type I): 50 %--FIL: 15.9 %
--SEA: 13.6 %IVS I-1 (-5 bp) GAGGTGAGG>GAGG----- donor: 9.1 %


CD 39 (CAG>TAG): 32.22 % (26.3 % – 38.96 %)IVS I-1 G>A: 12.66 % (5.3 % – 18.18 %)
IVS I-110 G>A: 10.93 % (5.3 % – 14.5 %)619 bp deletion: 10.5 %

 Detailed mutation frequencies

Entry IDLocusRegionEthnic GroupPopulation TypeSample SizeStudy period (from)Study period (to)ReferenceComments
19713β-locusGuadalajaraMexicanCarriers and Patients83200415315794Frequencies are shown for beta-globin gene mutations. Study samples were acquired from research centers in the Universidad de Guadalajara, Guadalajara. Seven of these were beta-thalassaemia patients.
19714β-locusMestizo MexicanCarriers and Patients1919911769663Frequencies are shown for beta-globin gene mutations, and were calculated by Ithanet.
19715α-locusMestizo MexicanCarriers and Patients44201527339814Frequencies are shown for alpha-globin gene mutations, and were calculated by Ithanet.
19716β-locusCountry-wideMexicanCarriers1542005201528603845Frequencies are shown for beta-globin gene mutations and were calculated by Ithanet. Study samples originated from all over the country, with the majority obtained from the Jalisco state.

  Organisations in Mexico

A list of all organisations in Mexico stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page

NameDepartmentOrganisation type
Universidad de GuadalajaraCentro Universitario en Ciencias de la SaludResearch Center, Higher Education


1Ibarra, Bertha2016-10-19Epidemiological data reviewed and updated.

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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.