Welcome to IthaMaps

IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.

IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge

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  General information for Cyprus


Cyprus
Continent: Europe
Capital: Nicosia
Population: 1102677
Area (in sq km): 9250.0

Haemoglobinopathy-specific healthcare policy information for Cyprus

Healthcare policyComment/InfoReference
Prevention programme: Yes (National)Based on premarital screening; since 1973.[PMID: 6109998]
SCD newborn screening: No[PMID: 24980780]
Prenatal screening: Yes (National)Since 1973.[PMID: 11773575]
Antenatal screening: Yes (National)[PMID: 24980780]
Haemoglobinopathies patient registry: Yes (National)[PMID: 24980780]
Rare disease patient registry: No[PMID: 24980780]
Dedicated treatment centres: Yes (National)ENERCA report Aug. 2013.
Blood transfusion availability: Yes (National)
Iron chelation availability: Yes (National)
Patient associations: Yes (National)e.g.: Cyprus Anti-Anaemia Association.
Genetic counselling: Yes (National)[PMID: 11773575]

  Prevalence and incidence of major haemoglobinopathies in Cyprus

HaemoglobinopathyComment/InfoReference
Prevalence of β-thalassaemia carriers: 12 % of the population[PMID: 24006929]
Prevalence of sickle cell disease carriers: 0.27 % of the population[PMID: 24672827]
Prevalence of α-thalassaemia carriers: 20 % of the population[PMID: 10975437]
Expected incidence of β-thalassaemia: 52 expected affected births/yearExtends between 50-60.[PMID: 24672827]
Expected incidence of sickle cell disease: 2 expected affected births/yearMostly sickle cell/beta-thalassaemia.
Incidence of β-thalassaemia: 0 affected births/yearExtends between 0-6 new cases.
Incidence of sickle cell disease: 2 affected births/yearMedian value estimated using statistical model and demographic data.[PMID: 23103089]
Known β-thalassaemia patients: 592 patients[PMID: 27199182]
Known sickle cell disease patients: 18 patients[PMID: 27199182]

Mutation frequencies in Cyprus

 Overview (most frequent mutations with their observed average values and range)

 α-locus

-α3.7 (type I): 62.89 % (50.6 % – 69.28 %)IVS I-1 (-5 bp) GAGGTGAGG>GAGG----- donor: 15.12 % (12.59 % – 17.57 %)
--MED I: 13.62 % (8.78 % – 23.44 %)-(α)20.5: 3.07 % (1.76 % – 4.95 %)

 β-locus

IVS I-110 G>A: 77.56 % (68.33 % – 92.16 %)CD 27 GCC>TCC [Ala>Ser] (Hb A2-Yialousa): 60.7 %
CD 4 ACT>ATT [Thr>Ile]: 17.8 %IVS I-6 (T>C): 8.8 % (3.27 % – 14.14 %)

 Detailed mutation frequencies

Entry IDLocusRegionEthnic GroupPopulation TypeSample SizeStudy period (from)Study period (to)ReferenceComments
20593β-locusLarnacaGreek CypriotCarriers4681995201527199182Frequencies are shown for beta-globin gene mutations. Data for Larnaca is merged with the smaller Famagusta district.
20594β-locusCountry-wideGreek CypriotCarriers23351995201527199182Frequencies are shown for beta-globin gene mutations.
20595β-locusLimassolGreek CypriotCarriers5251995201527199182Frequencies are shown for beta-globin gene mutations.
20596β-locusNicosiaGreek CypriotCarriers7221995201527199182Frequencies are shown for beta-globin gene mutations.
20597β-locusPaphosGreek CypriotCarriers1531995201527199182Frequencies are shown for beta-globin gene mutations.
20598β-locusLarnacaGreek CypriotPatients2881995201527199182Frequencies are shown for beta-globin gene mutations. Data for Larnaca is merged with the smaller Famagusta district.
20599β-locusLimassolGreek CypriotPatients3061995201527199182Frequencies are shown for beta-globin gene mutations.
20600β-locusNicosiaGreek CypriotPatients5021995201527199182Frequencies are shown for beta-globin gene mutations.
20601β-locusPaphosGreek CypriotPatients881995201527199182Frequencies are shown for beta-globin gene mutations.
20602β-locusCountry-wideGreek CypriotPatients11841995201527199182Frequencies are shown for beta-globin gene mutations.
20603α-locusLarnacaGreek CypriotCarriers24151995201527199182Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies. Data for Larnaca is merged with the smaller Famagusta district.
20604α-locusLimassolGreek CypriotCarriers21841995201527199182Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies.
20605α-locusNicosiaGreek CypriotCarriers41451995201527199182Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies.
20606α-locusPaphosGreek CypriotCarriers6831995201527199182Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies.
20607β-locusNicosiaGreek CypriotCarriers56200616987800Frequencies are shown for delta-globin gene mutations. Study samples were collected intermittently over a 15-month period from the Thalassaemia Centre at the Makarios Hospital, Nicosia, during routine carrier screening.

  Organisations in Cyprus

A list of all organisations in Cyprus stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page

NameDepartmentOrganisation type
Archbishop Makarios Hospital IIIThalassaemia CenterMedical Center, Diagnostic Center
Electronic Infrastructure for Thalassaemia Research Network (ITHANET)Research Project/Multi-Center Study, Scientific Organisation/Network
Larnaca General HospitalThalassaemia CenterMedical Center
Limassol General HospitalThalassaemia ClinicMedical Center
Pancyprian Thalassaemia AssociationPatient Society
Paphos General HospitalThalassaemia CenterMedical Center
Thalassaemia Center (Turkish Cypriot)Diagnostic Center
Thalassaemia International Federation (TIF)Scientific Society, Patient Society
The Cyprus Institute of Neurology and Genetics (CING)Molecular Genetics Thalassaemia DepartmentResearch Center, Medical Center, Higher Education, Diagnostic Center

 Microattributions

A/AContributor(s)DateComments
1Angastiniotis, Michael2016-03-28Provided information on healthcare policies and status of haemoglobinopathies as part of the HVP GG2020 Challenge.
2Kleanthous, Marina2016-07-11Information reviewed.

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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.