Welcome to IthaMaps
IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.
IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge
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General information for Cyprus
 Cyprus |
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Haemoglobinopathy-specific healthcare policy information for Cyprus
| Healthcare policy | Comment/Info | Reference | |
|---|---|---|---|
| Prevention programme: | Yes (National) | Based on premarital screening; since 1973. | [PMID: 6109998] |
| SCD newborn screening: | No | SCD is not included in the neonatal screening panel. | [PMID: 33808002] |
| Prenatal screening: | Yes (National) | Since 1973. | [PMID: 11773575] |
| Antenatal screening: | Yes (National) | [PMID: 24980780] | |
| Haemoglobinopathies patient registry: | Yes (National) | Cyprus Thalassaemia Patients Registry; covers all haemoglobinopathies [ERN-EuroBloodNet_Report on existing registries for RHD_2018] | [PMID: 30334577] |
| Rare disease patient registry: | No | [PMID: 24980780] | |
| Dedicated treatment centres: | Yes (National) | ENERCA report Aug. 2013. | |
| Blood transfusion availability: | Yes (National) | ||
| Iron chelation availability: | Yes (National) | ||
| Patient associations: | Yes (National) | e.g.: Cyprus Anti-Anaemia Association. | |
| Genetic counselling: | Yes (National) | [PMID: 11773575] |
Prevalence and incidence of major haemoglobinopathies in Cyprus
| Haemoglobinopathy | Comment/Info | Reference | |
|---|---|---|---|
| Prevalence of β-thalassaemia carriers: | 12 % of the population | [PMID: 24006929] | |
| Prevalence of sickle cell disease carriers: | 0.27 % of the population | [PMID: 24672827] | |
| Prevalence of α-thalassaemia carriers: | 20 % of the population | [PMID: 10975437] | |
| Expected incidence of β-thalassaemia: | 52 expected affected births/year | Extends between 50-60. | [PMID: 24672827] |
| Expected incidence of sickle cell disease: | 2 expected affected births/year | Mostly sickle cell/beta-thalassaemia. | |
| Incidence of β-thalassaemia: | 0 affected births/year | Extends between 0-6 new cases. | |
| Incidence of sickle cell disease: | 2 affected births/year | Median value estimated using statistical model and demographic data. | [PMID: 23103089] |
| Known β-thalassaemia patients: | 592 patients | [PMID: 27199182] | |
| Known sickle cell disease patients: | 18 patients | [PMID: 27199182] |
Global Burden of Disease data for Cyprus
Migration data for Cyprus
Mutation frequencies in Cyprus
Overview (most frequent mutations with their observed average values and range)
α-locus
| -α3.7 (type I): 62.89 % (50.6 % – 69.28 %) | IVS I-1 (-5 bp) GAGGTGAGG>GAGG----- donor: 15.12 % (12.59 % – 17.57 %) |
| --MED I: 13.62 % (8.78 % – 23.44 %) | -(α)20.5: 3.07 % (1.76 % – 4.95 %) |
β-locus
| IVS I-110 G>A: 77.56 % (68.33 % – 92.16 %) | CD 27 GCC>TCC [Ala>Ser] (Hb A2-Yialousa): 60.7 % |
| CD 4 ACT>ATT [Thr>Ile]: 17.8 % | IVS I-6 (T>C): 8.8 % (3.27 % – 14.14 %) |
Detailed mutation frequencies
| Entry ID | Locus | Region | Ethnic Group | Population Type | Sample Size | Study period (from) | Study period (to) | Reference | Comments | |
|---|---|---|---|---|---|---|---|---|---|---|
| 23134 | β-locus | Larnaca | Greek Cypriot | Carriers | 468 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. Data for Larnaca is merged with the smaller Famagusta district. | |
| 23135 | β-locus | Country-wide | Greek Cypriot | Carriers | 2335 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23136 | β-locus | Limassol | Greek Cypriot | Carriers | 525 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23137 | β-locus | Nicosia | Greek Cypriot | Carriers | 722 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23138 | β-locus | Paphos | Greek Cypriot | Carriers | 153 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23139 | β-locus | Larnaca | Greek Cypriot | Patients | 288 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. Data for Larnaca is merged with the smaller Famagusta district. | |
| 23140 | β-locus | Limassol | Greek Cypriot | Patients | 306 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23141 | β-locus | Nicosia | Greek Cypriot | Patients | 502 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23142 | β-locus | Paphos | Greek Cypriot | Patients | 88 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23143 | β-locus | Country-wide | Greek Cypriot | Patients | 1184 | 1995 | 2015 | 27199182 | Frequencies are shown for beta-globin gene mutations. | |
| 23144 | α-locus | Larnaca | Greek Cypriot | Carriers | 2415 | 1995 | 2015 | 27199182 | Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies. Data for Larnaca is merged with the smaller Famagusta district. | |
| 23145 | α-locus | Limassol | Greek Cypriot | Carriers | 2184 | 1995 | 2015 | 27199182 | Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies. | |
| 23146 | α-locus | Nicosia | Greek Cypriot | Carriers | 4145 | 1995 | 2015 | 27199182 | Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies. | |
| 23147 | α-locus | Paphos | Greek Cypriot | Carriers | 683 | 1995 | 2015 | 27199182 | Frequencies are shown for alpha-globin gene mutations. As these were not randomly sampled, the reported frequencies are an under-representation of the true population of allele frequencies. | |
| 23148 | β-locus | Nicosia | Greek Cypriot | Carriers | 56 | 2006 | 16987800 | Frequencies are shown for delta-globin gene mutations. Study samples were collected intermittently over a 15-month period from the Thalassaemia Centre at the Makarios Hospital, Nicosia, during routine carrier screening. |
Organisations in Cyprus
A list of all organisations in Cyprus stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page
| Name | Department | Organisation type |
|---|---|---|
| Archbishop Makarios Hospital III | Thalassaemia Center | Medical Center, Diagnostic Center |
| Electronic Infrastructure for Thalassaemia Research Network (ITHANET) | Research Project/Multi-Center Study, Scientific Organisation/Network | |
| Larnaca General Hospital | Thalassaemia Center | Medical Center |
| Limassol General Hospital | Thalassaemia Clinic | Medical Center |
| Pancyprian Thalassaemia Association | Patient Society | |
| Paphos General Hospital | Thalassaemia Center | Medical Center |
| Thalassaemia Center (Turkish Cypriot) | Diagnostic Center | |
| Thalassaemia International Federation (TIF) | Scientific Society, Patient Society | |
| The Cyprus Institute of Neurology and Genetics (CING) | Molecular Genetics Thalassaemia Department | Research Center, Medical Center, Higher Education, Diagnostic Center |
Microattributions
| A/A | Contributor(s) | Date | Comments |
|---|---|---|---|
| 1 | Angastiniotis, Michael | 2016-03-28 | Provided information on healthcare policies and status of haemoglobinopathies as part of the HVP GG2020 Challenge. |
| 2 | Kleanthous, Marina | 2016-07-11 | Information reviewed. |
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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.
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