Welcome to IthaMaps

IthaMaps is a global epidemiology database of heamoglobinopathies, illustrating published data on a dynamic global to regional map. Country-specific information on haemoglobinopathy-related policies, prevalence, incidence and overall disease burden is given, including relative allele frequencies of specific globin mutations in each country and/or region, dynamically linked to corresponding IthaGenes entries.

IthaMaps content was supported by partnership with the HVP Global Globin 2020 Challenge

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  General information for Bangladesh


Bangladesh
Continent: Asia
Capital: Dhaka
Population: 156118464
Area (in sq km): 144000.0

Haemoglobinopathy-specific healthcare policy information for Bangladesh

Healthcare policyComment/InfoReference
Prevention programme: Yes (National)National Thalassemia Prevention Program[PMID: 31941534]
SCD newborn screening: No[PMID: 28521805]
Prenatal screening: Yes (Regional)PND at Dhaka Shishu (Children) Hospital thalassaemia centre since 2014.
Antenatal screening: No[PMID: 25821805]
Haemoglobinopathies patient registry: Yes (Regional)Centre-based.
Dedicated treatment centres: Yes (Regional)E.g.: Thalassaemia Foundation Hospital in Dhaka.[PMID: 28521805]
Blood transfusion availability: Yes (Regional)[PMID: 28521805]
Iron chelation availability: Yes (Regional)[PMID: 28521805]
MRI facilities: No
Patient associations: Yes (National)E.g.: Bangladesh Thalassaemia Samity; Bangladesh Thalassaemia Foundation; Lab One Foundation of Thalassaemia; Thalassaemia Welfare Centre.
Genetic counselling: Yes (Regional)

  Prevalence and incidence of major haemoglobinopathies in Bangladesh

HaemoglobinopathyComment/InfoReference
Prevalence of β-thalassaemia carriers: 4.1 % of the population[PMID: 27040959]
Prevalence of sickle cell disease carriers: 1 % of the populationFrom: Thalassaemia Reports 2012, TIF Pan-Asian Conference.
Prevalence of Hb E carriers: 6.1 % of the populationIn tribal population at hill tract area at Chittagong & Bandarban District is about 41.7%.[PMID: 27040959]
Expected incidence of β-thalassaemia: 5477 expected affected births/year[PMID: 24672827]
Incidence of sickle cell disease: 16 affected births/yearMedian value estimated using statistical model and demographic data.[PMID: 23103089]
Known β-thalassaemia patients: 6880 patients[PMID: 24672827]

Mutation frequencies in Bangladesh

 Overview (most frequent mutations with their observed average values and range)

 β-locus

CD 26 GAG>AAG [Glu>Lys] (HbE): 60.32 % (40.2 % – 80.44 %) IVS I-5 (G>C): 27.10 % (15.11 % – 39.1 %)
CD 30 (G>C) or IVS I (-1) AGG>ACG (Arg>Thr) (Hb Monroe): 3.50 %CD 41/42 (-CTTT): 2.82 % (1.33 % – 4.3 %)

 Detailed mutation frequencies

Entry IDLocusRegionEthnic GroupPopulation TypeSample SizeStudy period (from)Study period (to)ReferenceComments
18752β-locusCountry-wideBangladeshiCarriers2252018201931941534Frequencies are shown for beta-globin gene mutations and were calculated by Ithanet. Marriage-age participants (n=1877) from 10 different institutions (universities, medical colleges and business organizations) of Dhaka city. The majority of study subjects carrying beta alleles were carriers (95.3%).
18753β-locusChittagongBangladeshiPatients256201526402558Frequencies are shown for beta-globin gene mutations. Study samples were acquired from the Thalassaemia Welfare Centre and originated from different areas of Chittagong.

  Organisations in Bangladesh

A list of all organisations in Bangladesh stored in the ITHANET database is shown below. For more information, click on the corresponding organisation name or visit the detailed ITHANET Organisations page

NameDepartmentOrganisation type
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)Research Center

 Microattributions

A/AContributor(s)DateComments
1Rahman, Hafizur2016-11-27Information on healthcare policies and the status of major haemoglobinopathies reviewed and updated.

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Important Note: The relative allele frequencies presented in IthaMaps are not calculated by ITHANET, but they are extracted from the corresponding publications. ITHANET is not responsible for any mistakes in the data. Please use this information with caution! We encourage scientists that have more detailed or updated epidemiological information to contact us.

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaMaps are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.