IthaID: 886
Names and Sequences
| Functionality: | Globin gene causative mutation | Pathogenicity: | Variant of Uncertain Significance |
|---|---|---|---|
| Common Name: | CD 24 GGT>GAT [Gly>Asp] | HGVS Name: | HBB:c.74G>A |
| Hb Name: | Hb Moscva | Protein Info: | β 24(B6) Gly>Asp |
Context nucleotide sequence:
GGCAAGGTGAACGTGGATGAAGTTG [A/G/T] TGGTGAGGCCCTGGGCAGGTTGGTA (Strand: -)
Protein sequence:
MVHLTPEEKSAVTALWGKVNVDEVDGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
Also known as:
We follow the HGVS sequence variant nomenclature and IUPAC standards.
Phenotype
| Hemoglobinopathy Group: | Structural Haemoglobinopathy |
|---|---|
| Hemoglobinopathy Subgroup: | β-chain variant |
| Allele Phenotype: | N/A |
| Stability: | Unstable |
| Oxygen Affinity: | Decreased Oxygen Affinity |
| Associated Phenotypes: | N/A |
Location
| Chromosome: | 11 |
|---|---|
| Locus: | NG_000007.3 |
| Locus Location: | 70668 |
| Size: | 1 bp |
| Located at: | β |
| Specific Location: | Exon 1 |
Other details
| Type of Mutation: | Point-Mutation(Substitution) |
|---|---|
| Effect on Gene/Protein Function: | Missense codons (Protein Structure) |
| Ethnic Origin: | Russian, Mauritanian |
| Molecular mechanism: | N/A |
| Inheritance: | Recessive |
| DNA Sequence Determined: | Yes |
In silico pathogenicity prediction
Note:
The impact thresholds provided in this section are based on the analyses performed in Tamana et.al. For any given tool, the impact thresholds defined for the set of variants with the same effect on function as the variant examined, are preferred over those defined for the full dataset.
Sequence Viewer
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Publications / Origin
- Idelson LI, Didkowsky NA, Casey R, Lorkin PA, Lehmann H, New unstable haemoglobin (Hb Moscva, beta24 (B4) Gly leads to Asp) found in the USSR., Nature, 249(459), 768-70, 1974 PubMed
- Ghaber SM, Trabelsi N, Salem ML, Haddad F, Abba A, Darragi I, Abbes S, Hb Moscva [β24(B6)Gly→Asp (GGT>GAT), HBB: c.74G>A]: An Unstable Hemoglobin Newly Detected as a De Novo Mutation in a Mauritanian Patient., Hemoglobin , 2018 PubMed
Created on 2010-06-16 16:13:16,
Last reviewed on 2018-04-03 18:11:39 (Show full history)
| A/A | Date | Curator(s) | Comments |
|---|---|---|---|
| 1 | 2010-06-16 16:13:16 | The IthaGenes Curation Team | Created |
| 2 | 2013-10-15 17:00:14 | The IthaGenes Curation Team | Reviewed. |
| 3 | 2018-04-03 18:11:39 | The IthaGenes Curation Team | Reviewed. Common name edited, Other details and Reference added. |
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IthaGenes was last updated on 2024-11-20 13:24:07