GeneID: 94


Common Name: ACKR1 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_011626.1 (ACKR1)
HUGO Symbol: ACKR1 Full Name: atypical chemokine receptor 1 (Duffy blood group)
Exons: 3 Introns: 2

The Duffy antigen receptor for chemokines (DARC/ACKR1) belongs to the family of atypical chemokine receptors (ACKRs) that bind to a variety of proinflammatory chemokines without eliciting a biological signal. Members of this family share the seven-transmembrane α-helix structure of G protein-coupled receptors, but lack the entire DRYLAIV sequence at the end of the third transmembrane domain, which is required for G-protein coupling and subsequent signalling. DARC is present on erythrocytes and post-capillary endothelial cells, as well as on a subset of neurons such as cerebellar Purkinje cells. DARC appears to regulate chemokine bioavailability and, consequently, leukocyte recruitment that helps reduce inflammation by scavenging chemokines in the circulation. DARC also serves as the erythroid receptor for the malarial parasites Plasmodium vivax and Plasmodium knowlesi. Two transcript variants encoding different isoforms have been found for this gene. Polymorphisms in this gene associated with pulmonary hypertension.

Synonyms: FY , CCBP1 , Dfy , GPD , DARC , CD234


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Publications / Origin

  1. Ashley-Koch AE, Elliott L, Kail ME, De Castro LM, Jonassaint J, Jackson TL, Price J, Ataga KI, Levesque MC, Weinberg JB, Orringer EP, Collins A, Vance JM, Telen MJ, Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease., Blood , 111(12), 5721-6, 2008 PubMed
  2. Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, Mantovani A, Matsushima K, Murphy PM, Nibbs R, Nomiyama H, Power CA, Proudfoot AE, Rosenkilde MM, Rot A, Sozzani S, Thelen M, Yoshie O, Zlotnik A, International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors., Pharmacol. Rev. , 66(1), 1-79, 2014 PubMed
  3. Horuk R, The Duffy Antigen Receptor for Chemokines DARC/ACKR1., Front Immunol , 6(0), 279, 2015 PubMed
Created on 2016-04-27 09:20:00, Last reviewed on 2017-03-13 14:56:39 (Show full history)

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