GeneID: 78


Common Name: MAP7 Type: Gene
Chromosome: 6 (NC_000006.12) Locus: N/A
HUGO Symbol: MAP7 Full Name: microtubule associated protein 7
Exons: 18 Introns: 17

MAP7 encodes a microtubule-associated protein, which, like other MAPs, is involved in the regulation of microtubule organization and stability. Microtubules are major components of the cytoskeleton and essential for many cellular functions, including cell shape and polarity, intracellular trafficking, cell motility and cell division. MAP7 is a retinoic acid-inducible gene that is predominantly expressed in cells of epithelial origin. The encoded protein is implicated in microtubule function required for spermatogenesis. Polymorphisms in this gene associated with HbF levels in sickle cell patients. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: EMAP115 , E-MAP-115


Sequence Viewer

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Publications / Origin

  1. Komada M, McLean DJ, Griswold MD, Russell LD, Soriano P, E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis., Genes Dev. , 14(11), 1332-42, 2000 PubMed
  2. Wyszynski DF, Baldwin CT, Cleves MA, Amirault Y, Nolan VG, Farrell JJ, Bisbee A, Kutlar A, Farrer LA, Steinberg MH, Polymorphisms near a chromosome 6q QTL area are associated with modulation of fetal hemoglobin levels in sickle cell anemia., Cell. Mol. Biol. (Noisy-le-grand) , 50(1), 23-33, 2004 PubMed
Created on 2016-04-26 15:50:01, Last reviewed on 2016-04-26 15:51:10 (Show full history)

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