GeneID: 492



Names

Common Name: PRKACB Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_029728.1 (PRKACB)
HUGO Symbol: PRKACB Full Name: protein kinase cAMP-activated catalytic subunit beta
Exons: 10 Introns: 9

Description:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP-dependent protein kinase (PKA), a tetrameric holoenzyme composed of 2 catalytic and 2 regulatory subunits. It plays a role in cAMP-dependent signaling, which is important to a number of processes, including cell proliferation and differentiation. PRKACB is predominantly expressed in the brain and has been implicated in neurodegenerative diseases. Sequence variation in this gene associated with stroke outcomes in patients with sickle cell disease.

Synonyms: CAFD2 , PKACB , PKA C-beta

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Brewin JN, Rooks H, Gardner K, Senior H, Morje M, Patel H, Calvet D, Bartolucci P, Thein SL, Menzel S, Rees DC, Genome wide association study of silent cerebral infarction in sickle cell disease (HbSS and HbSC)., Haematologica, 106(6), 1770-1773, 2021 PubMed
Created on 2022-03-29 13:31:19, Last reviewed on (Show full history)


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