GeneID: 481


Common Name: KLF6 Type: Gene
Chromosome: 10 (NC_000010.11) Locus: NG_012277.1 (KLF6)
HUGO Symbol: KLF6 Full Name: Kruppel like factor 6
Exons: 4 Introns: 3

The KLF6 gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator with key roles in several cellular processes and is considered a tumor suppressor. Functional studies showed that KLF6 suppression associates with an increase in γ-globin mRNA and protein levels in primary CD34+ HSPCs and HUDEP-2 cells. This is likely associated with microRNA miR-2355-5p [GeneID: 480], which specifically binds the seed region in the 3'UTR of KLF6. Overexpression of miR-2355-5p suppresses KLF6 and increases γ-globin synthesis. The miR-2355-5p/KLF6 interaction is a candidate therapeutic strategy for the treatment of patients with beta-haemoglobinopathies.

Synonyms: GBF , ZF9 , BCD1 , CBA1 , CPBP , PAC1 , ST12 , COPEB


Sequence Viewer

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Publications / Origin

  1. Cheng Y, Shang X, Chen D, Pang D, Zhao C, Xu X, MicroRNA-2355-5p regulates γ-globin expression in human erythroid cells by inhibiting KLF6., Br J Haematol, 193(2), 401-405, 2021 PubMed
Created on 2022-03-23 12:42:08, Last reviewed on (Show full history)

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