GeneID: 480


Common Name: miR-2355-5p Type: Gene
Chromosome: 2 (NC_000002.12) Locus: NR_036227.1 (MIR2355)
HUGO Symbol: MIR2355 Full Name: microRNA 2355
Exons: N/A Introns: N/A

MicroRNAs (miRNAs), such as MIR2355, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. The miR-2355-5p sequence is a product of MIR2355. Functional studies showed that overexpression of miR-2355-5p in primary CD34+ HSPCs and HUDEP-2 cells correlates with an increase in γ-globin synthesis by suppressing KLF6 [GeneID: 481] expression. miR-2355-5p specifically binds the seed region in the 3'UTR of KLF6. The miR-2355-5p/KLF6 interaction is a candidate therapeutic strategy for the treatment of patients with beta-haemoglobinopathies.

Synonyms: N/A


External Links

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Publications / Origin

  1. Cheng Y, Shang X, Chen D, Pang D, Zhao C, Xu X, MicroRNA-2355-5p regulates γ-globin expression in human erythroid cells by inhibiting KLF6., Br J Haematol, 193(2), 401-405, 2021 PubMed
Created on 2022-03-23 12:38:49, Last reviewed on (Show full history)

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