GeneID: 48


Common Name: GDF15 Type: Gene
Chromosome: 19 (NC_000019.10) Locus: N/A
HUGO Symbol: GDF15 Full Name: growth differentiation factor 15
Exons: 2 Introns: 1

GDF15 is a member of the transforming growth factor β (TGFβ) family. The protein is a stress response cytokine expressed in a variety of cell types. Protein levels are rapidly enhanced by stress stimuli such as tissue hypoxia, oxidative injury and inflammation. Increased GDF15 expression is linked to several biological processes including cancer and chronic inflammatory diseases. Polymorphisms in the GDF15 gene associated with elevated GDF15 and concomitant suppression of hepcidin (regulator of iron homeostasis) in Indian β-thalassemia patients.

Synonyms: MIC-1 , MIC1 , NAG-1 , PDF , PLAB , PTGFB


Sequence Viewer

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Publications / Origin

  1. Lawton LN, Bonaldo MF, Jelenc PC, Qiu L, Baumes SA, Marcelino RA, de Jesus GM, Wellington S, Knowles JA, Warburton D, Brown S, Soares MB, Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta., Gene , 203(1), 17-26, 1997 PubMed
  2. Kempf T, Wollert KC, Growth-differentiation factor-15 in heart failure., Heart Fail Clin , 5(4), 537-47, 2009 PubMed
  3. Athiyarath R, George B, Mathews V, Srivastava A, Edison ES, Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in β-thalassemia., Ann. Hematol. , 93(12), 2093-5, 2014 PubMed
Created on 2016-04-25 15:51:34, Last reviewed on (Show full history)

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