GeneID: 48



Names

Common Name: GDF15 Type: Gene
Chromosome: 19 (NC_000019.10) Locus: N/A
HUGO Symbol: GDF15 Full Name: growth differentiation factor 15
Exons: 2 Introns: 1

Description:
GDF15 is a member of the transforming growth factor β (TGFβ) family. The protein is a stress response cytokine expressed in a variety of cell types. Protein levels are rapidly enhanced by stress stimuli such as tissue hypoxia, oxidative injury and inflammation. Increased GDF15 expression is linked to several biological processes including cancer and chronic inflammatory diseases. Polymorphisms in the GDF15 gene associated with elevated GDF15 and concomitant suppression of hepcidin (regulator of iron homeostasis) in Indian β-thalassemia patients.

Synonyms: MIC-1 , MIC1 , NAG-1 , PDF , PLAB , PTGFB

Comments:
N/A

Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Lawton LN, Bonaldo MF, Jelenc PC, Qiu L, Baumes SA, Marcelino RA, de Jesus GM, Wellington S, Knowles JA, Warburton D, Brown S, Soares MB, Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta., Gene , 203(1), 17-26, 1997 PubMed
  2. Kempf T, Wollert KC, Growth-differentiation factor-15 in heart failure., Heart Fail Clin , 5(4), 537-47, 2009 PubMed
  3. Athiyarath R, George B, Mathews V, Srivastava A, Edison ES, Association of growth differentiation factor 15 (GDF15) polymorphisms with serum GDF15 and ferritin levels in β-thalassemia., Ann. Hematol. , 93(12), 2093-5, 2014 PubMed
Created on 2016-04-25 15:51:34, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Please publish modules in offcanvas position.