GeneID: 476


Common Name: miR-144 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NR_029685.1 (MIR144)
HUGO Symbol: MIR144 Full Name: microRNA 144
Exons: N/A Introns: N/A

MicroRNAs (miRNAs), such as MIR144, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. miR-144 expression was elevated in the peripheral blood reticulocytes of sickle cell disease (SCD) patients with low fetal hemoglobin levels. Functional studies in vitro showed NRF2 gene [GeneID: 243] silencing by miR-144 and concomitant repression of γ-globin transcription in sickle erythroid progenitors. Also, miR-144 expression was increased in SCD patients with leg ulcers and associated with hemolytic biomarkers (e.g., NO metabolites, LDH, AST, GGT, iron and ferritin), in addition to an impaired clinical profile of sickle leg ulcers. miR-144 may be part of the genetic background responsible for hemolytic pathophysiology in the occurrence and clinical evolution of sickle cell ulcers.

Synonyms: MIRN144 , mir-144


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Publications / Origin

  1. Li B, Zhu X, Ward CM, Starlard-Davenport A, Takezaki M, Berry A, Ward A, Wilder C, Neunert C, Kutlar A, Pace BS, MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease., Exp. Hematol., 70(0), 85-96.e5, 2019 PubMed
  2. Santos EDC, Melo GIV, Santana PVB, Quadros IGS, Yahouédéhou SCMA, Guarda CCD, Santiago RP, Fiuza LM, Carvalho SP, Adorno EV, Kaneto CM, Fonseca TCC, Goncalves MS, Aleluia MM, A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126., Biomolecules, 12(2), 0, 2022 PubMed
Created on 2022-03-11 20:29:33, Last reviewed on (Show full history)

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