GeneID: 476
Names
Common Name: | miR-144 | Type: | Gene |
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Chromosome: | 17 (NC_000017.11) | Locus: | NR_029685.1 (MIR144) |
HUGO Symbol: | MIR144 | Full Name: | microRNA 144 |
Exons: | N/A | Introns: | N/A |
Description:
MicroRNAs (miRNAs), such as MIR144, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. It is involved in the regulation of human erythropoiesis by targeting the RAB14 GTPase, a component of the endosomal recycling pathway. It contributes to a severe anemia phenotype in sickle cell disease (SCD) via downregulation of the NRF2 gene [GeneID: 243] and subsequent reduction of oxidative stress tolerance in SCD erythrocytes. A concomitant reduction in γ-globin gene expression is seen in SCD erythrocytes. It is implicated in the hemolytic mechanism driving the occurence and clinical evolution of sickle leg ulcers.
Synonyms: MIRN144 , mir-144
Comments:
N/A
Number of entries/variants: 0
IthaScore
Sequence Viewer
Publications / Origin
- Sangokoya C, Telen MJ, Chi JT, microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease., Blood, 116(20), 4338-48, 2010 PubMed
- Li B, Zhu X, Ward CM, Starlard-Davenport A, Takezaki M, Berry A, Ward A, Wilder C, Neunert C, Kutlar A, Pace BS, MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease., Exp. Hematol., 70(0), 85-96.e5, 2019 PubMed
- Santos EDC, Melo GIV, Santana PVB, Quadros IGS, Yahouédéhou SCMA, Guarda CCD, Santiago RP, Fiuza LM, Carvalho SP, Adorno EV, Kaneto CM, Fonseca TCC, Goncalves MS, Aleluia MM, A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126., Biomolecules, 12(2), 0, 2022 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2022-03-11 20:29:33 | The IthaGenes Curation Team | Created |
2 | 2023-01-17 16:01:00 | The IthaGenes Curation Team | Reviewed. Reference added, Comment updated. |