GeneID: 474


Common Name: Let-7i-5p Type: Gene
Chromosome: 12 (NC_000012.12) Locus: NR_029661.1 (MIRLET7I)
HUGO Symbol: MIRLET7I Full Name: microRNA let-7i
Exons: N/A Introns: N/A

MicroRNAs (miRNAs), such as MIRNLET7I, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. Homo sapiens (human) hsa-let-7i-5p sequence is a product of MIRLET7I. The let-7i-5p is an erythrocytic miRNA implicated in sickle cell disease (SCD) and malaria pathogenesis. It is differentially expressed in plasma exosomes isolated from individuals with different sickle hemoglobin variants. Functional studies in vitro revealed an increased expression of let-7i-5p in HbSS and HbAS erythrocytes without malaria. Predictions of let-7i-5p gene targets indicate that it may alter SCD and malaria pathogenesis through inflammatory pathways. Let-7i-5p is a candidate biomarker of pathogenesis for both diseases.

Synonyms: LET7I , let-7i , MIRNLET7I , hsa-let-7i


External Links

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Publications / Origin

  1. Oxendine Harp K, Bashi A, Botchway F, Dei-Adomakoh Y, Iqbal SA, Wilson MD, Adjei AA, Stiles JK, Driss A, MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria., J Clin Med, 11(3), , 2022 PubMed
Created on 2022-03-11 12:28:53, Last reviewed on (Show full history)

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