GeneID: 468


Common Name: FLVCR1 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_028131.1 (FLVCR1)
HUGO Symbol: FLVCR1 Full Name: FLVCR heme transporter 1
Exons: 10 Introns: 9

The FLVCR1 gene encodes the feline leukemia virus subgroup C receptor 1, a heme-transporter protein that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies.

Synonyms: PCA , AXPC1 , FLVCR , PCARP , MFSD7B , SLC49A1


Sequence Viewer

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Publications / Origin

The are no peer-reviewed publications available for this gene.

Created on 2022-01-19 10:35:05, Last reviewed on (Show full history)

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