GeneID: 466
Names
Common Name: | OPG | Type: | Gene |
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Chromosome: | 8 (NC_000008.11) | Locus: | NG_012202.1 (TNFRSF11B) |
HUGO Symbol: | TNFRSF11B | Full Name: | TNF receptor superfamily member 11b |
Exons: | 5 | Introns: | 4 |
Description:
The TNFRSF11B gene, also known as OPG (osteoprotegerin), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays an important role in bone metabolism. It acts as a decoy receptor for TNFSF11 (or RANKL) [GeneID: 465], and thereby neutralizes its function in osteoclastogenesis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. Studies reported that the RANK/RANKL/OPG system may have an important role in regulating bone metabolism in transfusion-dependent β-thalassemia patients.
Synonyms: OPG , TR1 , OCIF , PDB5
Comments:
N/A
Number of entries/variants: 2
Sequence Viewer
Publications / Origin
- Ono T, Hayashi M, Sasaki F, Nakashima T, RANKL biology: bone metabolism, the immune system, and beyond., Inflamm Regen, 40(0), 2, 2020 PubMed
- Youssry I, Saad N, Madboly M, Samy RM, Hamed ST, Tawfik H, Elbatrawy SR, Kaddah N, Abd Elaziz D, Bone health in pediatric transfusion-dependent beta-thalassemia: Circulating osteoprotegerin and RANKL system., Pediatr Blood Cancer, 69(1), e29377, 2022 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2021-12-29 10:20:02 | The IthaGenes Curation Team | Created |