GeneID: 466


Common Name: OPG Type: Gene
Chromosome: 8 (NC_000008.11) Locus: NG_012202.1 (TNFRSF11B)
HUGO Symbol: TNFRSF11B Full Name: TNF receptor superfamily member 11b
Exons: 5 Introns: 4

The TNFRSF11B gene, also known as OPG (osteoprotegerin), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays an important role in bone metabolism. It acts as a decoy receptor for TNFSF11 (or RANKL) [GeneID: 465], and thereby neutralizes its function in osteoclastogenesis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. Studies reported that the RANK/RANKL/OPG system may have an important role in regulating bone metabolism in transfusion-dependent β-thalassemia patients.

Synonyms: OPG , TR1 , OCIF , PDB5


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Publications / Origin

  1. Ono T, Hayashi M, Sasaki F, Nakashima T, RANKL biology: bone metabolism, the immune system, and beyond., Inflamm Regen, 40(0), 2, 2020 PubMed
  2. Youssry I, Saad N, Madboly M, Samy RM, Hamed ST, Tawfik H, Elbatrawy SR, Kaddah N, Abd Elaziz D, Bone health in pediatric transfusion-dependent beta-thalassemia: Circulating osteoprotegerin and RANKL system., Pediatr Blood Cancer, 69(1), e29377, 2022 PubMed
Created on 2021-12-29 10:20:02, Last reviewed on (Show full history)

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