GeneID: 458


Common Name: miR-96 Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NG_023385.1 (MIR96)
HUGO Symbol: MIR96 Full Name: microRNA 96
Exons: N/A Introns: N/A

MicroRNAs (miRNAs), such as MIR96, are small, non-coding RNAs that play key roles in the post-transcriptional regulation of gene expression by targeting specific mRNAs. Reporter gene assays demonstrated that MIR96 directly and sequence specifically targets the open reading frame (ORF) of the γ-globin mRNA, thereby inhibiting γ-globin expression. Additional evidence showed that MIR96 expression levels inversely correlated with increased HbF synthesis in erythroid cells of beta-thalassaemia patients. Therapeutic approaches that increase the HbF concentration have great potential for ameliorating the clinical and haematologic severity of beta-thalassaemia and other beta-haemoglobinopathies.

Synonyms: DFNA50 , MIRN96 , miR-96 , miRNA96 , hsa-mir-96


External Links

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Publications / Origin

  1. Azzouzi I, Moest H, Winkler J, Fauchère JC, Gerber AP, Wollscheid B, Stoffel M, Schmugge M, Speer O, MicroRNA-96 directly inhibits γ-globin expression in human erythropoiesis., PLoS One, 6(7), e22838, 2011 PubMed
  2. Eltaweel NH, ElKamah GY, Khairat R, Atia HAE, Amr KS, Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia., J Genet Eng Biotechnol, 19(1), 51, 2021 PubMed
Created on 2021-09-22 14:54:45, Last reviewed on (Show full history)

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