GeneID: 447


Common Name: PRDX1 Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NM_181697.3 (PRDX1)
HUGO Symbol: PRDX1 Full Name: peroxiredoxin 1
Exons: 6 Introns: 5

The PRDX1 gene encodes a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize hydrogen peroxide (H2O2) and act as a molecular chaperone, respectively. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. PRDX1 gene expression and protein levels were found to be elevated in the reticulocytes and erythrocytes of β-thalassaemia intermedia patients compared to healthy controls. Possible role in protecting red cells from oxidative damage.

Synonyms: PAG , PAGA , PAGB , PRX1 , PRXI , MSP23 , NKEFA , TDPX2 , NKEF-A


Sequence Viewer

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Publications / Origin

  1. Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021 PubMed
Created on 2021-08-19 16:53:31, Last reviewed on (Show full history)

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