GeneID: 446



Names

Common Name: BACH1 Type: Gene
Chromosome: 21 (NC_000021.9) Locus: NG_029658.2 (BACH1)
HUGO Symbol: BACH1 Full Name: BTB domain and CNC homolog 1
Exons: 5 Introns: 4

Description:
BACH1 is a member of the Cap ‘n' Collar and basic region leucine zipper family (CNC-bZip) of transcription factors that acts as a repressor or activator, depending on the context. It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity. It forms a heterodimer with small MAF proteins to bind MAF recognition elements (MAREs) in the promoters of target genes to supress their expression, including heme-responsive genes like α- and β-globin, and oxidative stress-response genes like heme oxygenase-1 (HO-1) and NADPH quinone oxidoreductase 1 (NQO1). The reduction of heme content in β-thalassaemia red cells led to an increase in BACH1 gene expression, which positively correlated to α-, β-, and γ-globin gene expression and to HO-1 gene expression. The expression of BACH1 could be elevated as a compensatory mechanism to decrease the α/β-globin chain imbalance and to reduce the oxidative stress produced by the imbalance.

Synonyms: BACH-1 , BTBD24

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Lee TY, Muniandy L, Teh LK, Abdullah M, George E, Sathar J, Lai MI, Correlation of BACH1 and Hemoglobin E/Beta-Thalassemia Globin Expression., Turk J Haematol, 33(1), 15-20, 2016 PubMed
  2. Zakaria NA, Islam MA, Abdullah WZ, Bahar R, Mohamed Yusoff AA, Abdul Wahab R, Shamsuddin S, Johan MF, Epigenetic Insights and Potential Modifiers as Therapeutic Targets in -Thalassemia., Biomolecules, 11(5), 0, 2021 PubMed
Created on 2021-08-19 15:48:33, Last reviewed on (Show full history)


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