GeneID: 426


Common Name: TLR10 Type: Gene
Chromosome: 4 (NC_000004.12) Locus: NM_030956.4 (TLR10)
HUGO Symbol: TLR10 Full Name: toll like receptor 10
Exons: 4 Introns: 3

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR10 has a modulatory effect upon the inflammatory reactions exerted by other members of the TLR family. Several SNPs around TLR10 showed modest association with increasing alloantibodies in sickle cell disease.

Synonyms: CD290


Sequence Viewer

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Publications / Origin

  1. Oosting M, Cheng SC, Bolscher JM, Vestering-Stenger R, Plantinga TS, Verschueren IC, Arts P, Garritsen A, van Eenennaam H, Sturm P, Kullberg BJ, Hoischen A, Adema GJ, van der Meer JW, Netea MG, Joosten LA, Human TLR10 is an anti-inflammatory pattern-recognition receptor., Proc Natl Acad Sci U S A, 111(42), E4478-84, 2014 PubMed
  2. Hanchard NA, Moulds JM, Belmont JW, Chen A, A Genome-Wide Screen for Large-Effect Alloimmunization Susceptibility Loci among Red Blood Cell Transfusion Recipients with Sickle Cell Disease., Transfus Med Hemother, 41(6), 453-61, 2014 PubMed
Created on 2021-02-03 18:44:08, Last reviewed on 2021-02-03 18:52:11 (Show full history)

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