GeneID: 421
Names
Common Name: | FGF23 | Type: | Gene |
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Chromosome: | 12 (NC_000012.12) | Locus: | NG_007087.1 (FGF23) |
HUGO Symbol: | FGF23 | Full Name: | fibroblast growth factor 23 |
Exons: | 3 | Introns: | 2 |
Description:
FGF23 belongs to the fibroblast growth factor (FGF) family of proteins that are involved in a wide variety of cellular processes including proliferation, differentiation, migration and apoptosis. FGF23 is mainly secreted by skeletal osteocytes and osteoblasts, and plays a key role in the regulation of phosphate homeostasis by negative feedback mechanisms involving the kidney and parathyroid. It also controls the production of 1,25-dihydroxyvitamin D (1,25[OH]2D). High levels of FGF23 were reported in beta-thalassaemia patients with hypoparathyroidism, either due to a stimulatory effect of parathyroid hormone and 1,25(OH)2D3 on FGF23 production, or direct induction effect of ferritin.
Synonyms: ADHR , FGFN , HYPF , HFTC2 , HPDR2 , PHPTC
Comments:
N/A
Sequence Viewer
Publications / Origin
- Saki F, Salehifar A, Kassaee SR, Omrani GR, Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study., BMC Nephrol, 21(1), 482, 2020 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2021-01-25 16:06:27 | The IthaGenes Curation Team | Created |