GeneID: 421



Names

Common Name: FGF23 Type: Gene
Chromosome: 12 (NC_000012.12) Locus: NG_007087.1 (FGF23)
HUGO Symbol: FGF23 Full Name: fibroblast growth factor 23
Exons: 3 Introns: 2

Description:
FGF23 belongs to the fibroblast growth factor (FGF) family of proteins that are involved in a wide variety of cellular processes including proliferation, differentiation, migration and apoptosis. FGF23 is mainly secreted by skeletal osteocytes and osteoblasts, and plays a key role in the regulation of phosphate homeostasis by negative feedback mechanisms involving the kidney and parathyroid. It also controls the production of 1,25-dihydroxyvitamin D (1,25[OH]2D). High levels of FGF23 were reported in beta-thalassaemia patients with hypoparathyroidism, either due to a stimulatory effect of parathyroid hormone and 1,25(OH)2D3 on FGF23 production, or direct induction effect of ferritin.

Synonyms: ADHR , FGFN , HYPF , HFTC2 , HPDR2 , PHPTC

Comments:
N/A

Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Saki F, Salehifar A, Kassaee SR, Omrani GR, Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study., BMC Nephrol, 21(1), 482, 2020 PubMed
Created on 2021-01-25 16:06:27, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.