GeneID: 418


Common Name: UHRF1 Type: Gene
Chromosome: 19 (NC_000019.10) Locus: NG_033256.2 (UHRF1)
HUGO Symbol: UHRF1 Full Name: ubiquitin like with PHD and ring finger domains 1
Exons: 17 Introns: 16

The UHRF1 gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. It acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful maintenance of DNA methylation during DNA replication. Disruption of UHRF1 led to increased HbF protein levels in HUDEP-2 cells and in erythroid cells derived from normal adult blood CD34+ cells. UHRF1 regulates γ-globin transcription, likely through methylation of CpG sites at the γ-globin gene promoters. Source:

Synonyms: Np95 , hNP95 , ICBP90 , RNF106 , TDRD22 , hUHRF1 , huNp95


Sequence Viewer

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Publications / Origin

The are no peer-reviewed publications available for this gene.

Created on 2020-12-01 15:21:07, Last reviewed on 2020-12-01 15:24:37 (Show full history)

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