GeneID: 407
Names
Common Name: | MED27 | Type: | Gene |
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Chromosome: | 9 (NC_000009.12) | Locus: | NM_004269.4 (MED27) |
HUGO Symbol: | MED27 | Full Name: | mediator complex subunit 27 |
Exons: | 8 | Introns: | 7 |
Description:
The MED27 gene encodes a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Genetic variance in MED27 associated with F-cell levels in sickle cell anaemia.
Synonyms: MED3 , CRSP8 , CRAP34 , CRSP34 , TRAP37
Comments:
N/A
Number of entries/variants: 1
IthaScore
Sequence Viewer
Publications / Origin
- Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2020-10-15 12:30:31 | The IthaGenes Curation Team | Created |