GeneID: 407



Names

Common Name: MED27 Type: Gene
Chromosome: 9 (NC_000009.12) Locus: NM_004269.4 (MED27)
HUGO Symbol: MED27 Full Name: mediator complex subunit 27
Exons: 8 Introns: 7

Description:
The MED27 gene encodes a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Genetic variance in MED27 associated with F-cell levels in sickle cell anaemia.

Synonyms: MED3 , CRSP8 , CRAP34 , CRSP34 , TRAP37

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed
Created on 2020-10-15 12:30:31, Last reviewed on (Show full history)


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