GeneID: 402


Common Name: ARHGEF3 Type: Gene
Chromosome: 3 (NC_000003.12) Locus: NM_019555.3 (ARHGEF3)
HUGO Symbol: ARHGEF3 Full Name: Rho guanine nucleotide exchange factor 3
Exons: 10 Introns: 9

ARHGEF3 belongs to the family of Rho guanine nucleotide exchange factors (RhoGEFs), which activate Rho GTPases by catalyzing the exchange of GDP for GTP. It specifically activates two members of the Rho GTPase family, RhoA and RhoB. RhoA is important for haematopoiesis. A series of experiments showed that ARHGEF3 regulates erythropoiesis, and is also involved in the regulatory mechanism of erythroid regeneration from anaemia induced by chemotherapy. Genetic variance in ARHGEF3 associated with F-cell levels in sickle cell disease.

Synonyms: GEF3 , STA3 , XPLN


Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed
  2. Xie Y, Gao L, Xu C, Chu L, Gao L, Wu R, Liu Y, Liu T, Sun XJ, Ren R, Tang J, Zheng Y, Zhou Y, Shen S, ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients., Haematologica, 105(4), 925-936, 2020 PubMed
Created on 2020-10-06 16:57:30, Last reviewed on (Show full history)

Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.