GeneID: 402
Names
| Common Name: | ARHGEF3 | Type: | Gene |
|---|---|---|---|
| Chromosome: | 3 (NC_000003.12) | Locus: | NM_019555.3 (ARHGEF3) |
| HUGO Symbol: | ARHGEF3 | Full Name: | Rho guanine nucleotide exchange factor 3 |
| Exons: | 10 | Introns: | 9 |
Description:
ARHGEF3 belongs to the family of Rho guanine nucleotide exchange factors (RhoGEFs), which activate Rho GTPases by catalyzing the exchange of GDP for GTP. It specifically activates two members of the Rho GTPase family, RhoA and RhoB. RhoA is important for haematopoiesis. A series of experiments showed that ARHGEF3 regulates erythropoiesis, and is also involved in the regulatory mechanism of erythroid regeneration from anaemia induced by chemotherapy. Genetic variance in ARHGEF3 associated with F-cell levels in sickle cell disease.
Synonyms: GEF3 , STA3 , XPLN
Comments:
N/A
Number of entries/variants: 1
IthaScore
Sequence Viewer
Publications / Origin
- Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed
- Xie Y, Gao L, Xu C, Chu L, Gao L, Wu R, Liu Y, Liu T, Sun XJ, Ren R, Tang J, Zheng Y, Zhou Y, Shen S, ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients., Haematologica, 105(4), 925-936, 2020 PubMed
| A/A | Date | Curator(s) | Comments |
|---|---|---|---|
| 1 | 2020-10-06 16:57:30 | The IthaGenes Curation Team | Created |