GeneID: 388


Common Name: JUN Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_047027.1 (JUN)
HUGO Symbol: JUN Full Name: Jun proto-oncogene, AP-1 transcription factor subunit
Exons: 1 Introns: 0

The oncogene JUN is the putative transforming gene of avian sarcoma virus 17; it appears to be derived from a gene of the chicken genome and has homologs in several other vertebrate species. A series of experiments demonstrated that JUN activates the Gγ-globin gene via binding to the upstream Gγ-globin gene cAMP response element (G-CRE) in a manner comparable to CREB [GeneID: 385] and ATF-2 [GeneID: 387]. JUN binds the G-CRE as a heterodimer with ATF-2 to modulate γ-globin expression.

Synonyms: AP1 , p39 , AP-1 , cJUN , c-Jun


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Publications / Origin

  1. Kodeboyina S, Balamurugan P, Liu L, Pace BS, cJun modulates Ggamma-globin gene expression via an upstream cAMP response element., Blood Cells Mol. Dis., 44(1), 7-15, 2010 PubMed
Created on 2020-09-18 14:05:02, Last reviewed on (Show full history)

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