GeneID: 388
Names
Common Name: | JUN | Type: | Gene |
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Chromosome: | 1 (NC_000001.11) | Locus: | NG_047027.1 (JUN) |
HUGO Symbol: | JUN | Full Name: | Jun proto-oncogene, AP-1 transcription factor subunit |
Exons: | 1 | Introns: | 0 |
Description:
The oncogene JUN is the putative transforming gene of avian sarcoma virus 17; it appears to be derived from a gene of the chicken genome and has homologs in several other vertebrate species. A series of experiments demonstrated that JUN activates the Gγ-globin gene via binding to the upstream Gγ-globin gene cAMP response element (G-CRE) in a manner comparable to CREB [GeneID: 385] and ATF-2 [GeneID: 387]. JUN binds the G-CRE as a heterodimer with ATF-2 to modulate γ-globin expression.
Synonyms: AP1 , p39 , AP-1 , cJUN , c-Jun
Comments:
N/A
Number of entries/variants: 0
Sequence Viewer
Publications / Origin
- Kodeboyina S, Balamurugan P, Liu L, Pace BS, cJun modulates Ggamma-globin gene expression via an upstream cAMP response element., Blood Cells Mol. Dis., 44(1), 7-15, 2010 PubMed
A/A | Date | Curator(s) | Comments |
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1 | 2020-09-18 14:05:02 | The IthaGenes Curation Team | Created |