GeneID: 385


Common Name: CREB1 Type: Gene
Chromosome: 2 (NC_000002.12) Locus: NG_023299.1 (CREB1)
HUGO Symbol: CREB1 Full Name: Cyclic AMP-responsive element-binding protein 1
Exons: 8 Introns: 7

The CREB1 gene encodes a transcription factor that belongs to the family of leucine zipper proteins (bZIP). The basic leucine zipper motif allows for dimerization and sequence-specific DNA-binding interactions. A series of knockdown experiments in erythroid cell lines and primary erythroid progenitors supported a role for CREB1 signaling in Gγ-globin gene transcription. CREB1 and its binding partner CREB binding protein (CBP) [GeneID: 386] co-localize at the Gγ-globin cAMP response element (G-CRE) located between -1222 and -1229 relative to the cap site to induce γ-globin expression through a p38 mitogen-activated protein kinase-dependent mechanism. Genetic variation in the G-CRE region associated with foetal haemoglobin (HbF) levels in sickle cell disease.

Synonyms: CREB , CREB-1


Sequence Viewer

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Publications / Origin

  1. Ramakrishnan V, Pace BS, Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway., Blood Cells Mol. Dis., 47(1), 12-22, 2011 PubMed
  2. Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS, A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease., Exp. Biol. Med. (Maywood) , 2016 PubMed
Created on 2020-09-18 10:35:07, Last reviewed on 2020-09-18 10:57:21 (Show full history)

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