GeneID: 379


Common Name: ATF4 Type: Gene
Chromosome: 22 (NC_000022.11) Locus: NM_001675.4 (ATF4)
HUGO Symbol: ATF4 Full Name: activating transcription factor 4
Exons: 2 Introns: 1

The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These proteins bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. CRISPR-Cas screening in HUDEP-2 cells identified ATF4 as a regulator of γ-globin transcription through direct transcriptional control of BCL11A, a known repressor of γ-globin transcription. ATF4 stimulates transcription of BCL11A by binding to its enhancer (+55) and increasing enhancer-promoter contacts. ATF4 is regulated by HRI [GeneID: 264], and serves as a critical component in γ-globin silencing (linear signaling pathway from HRI to ATF4 to BCL11A to γ-globin).

Synonyms: CREB2 , TXREB , CREB-2 , TAXREB67


Sequence Viewer

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Publications / Origin

  1. Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA, The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression., Blood, 135(24), 2121-2132, 2020 PubMed
Created on 2020-06-15 16:06:35, Last reviewed on 2020-06-15 16:11:50 (Show full history)

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