GeneID: 373



Names

Common Name: ETO2 Type: Gene
Chromosome: 16 (NC_000016.10) Locus: NG_029533.1 (CBFA2T3 )
HUGO Symbol: CBFA2T3 Full Name: CBFA2/RUNX1 partner transcriptional co-repressor 3
Exons: 12 Introns: 11

Description:
CBFA2T3 (commonly known as ETO2) is a transcriptional repressor that interacts with several members of histone deacetylases (HDACs) critical to facilitate transcriptional repression. It is part of a TAL-1-containing complex in erythroid cells, recruited through interaction with E2A/HEB. Other TAL-1 partners include GATA-1, LMO2 and Ldb1. This complex occupies the β-globin locus control region (βLCR) and the BGL3 non-coding transcript region downstream of the HBG1 gene. Transcription of the BGLT3 locus is critical for γ-globin gene long-range looping interactions with the β-LCR. The γ-globin/BGL3 region is also occupied by BCL11A, a well-established negative regulator of fetal haemoglobin (HbF) expression. Knock-down of ETO2 upregulates γ-globin and BGL3 transcription in erythroid K562 cells. Ectopic expression and siRNA knockdown experiments in haematopoietic progenitor cells show that ETO2 actively represses erythroid TAL-1 target genes and regulates the expansion of erythroid progenitors.

Synonyms: MTG16 , MTGR2 , ZMYND4 , RUNX1T3

Comments:
N/A

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Publications / Origin

  1. Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T, ETO2 coordinates cellular proliferation and differentiation during erythropoiesis., EMBO J., 25(2), 357-66, 2006 PubMed
  2. Kiefer CM, Lee J, Hou C, Dale RK, Lee YT, Meier ER, Miller JL, Dean A, Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells., Blood, 118(23), 6200-8, 2011 PubMed
Created on 2020-03-27 19:55:05, Last reviewed on 2020-03-30 15:55:45 (Show full history)


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