GeneID: 372


Common Name: IKAROS Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NG_034231.1 (IKZF1)
HUGO Symbol: IKZF1 Full Name: IKAROS family zinc finger 1
Exons: 8 Introns: 7

The IKZF1 gene encodes a member of a family of haematopoietic zinc finger transcription factors. It is a transcription regulator of haematopoietic cell differentiation. It has been associated with histone-modifying and chromatin-remodeling activities and shown to target the PYR complex (SWI/SNF and NuRD components) to a region between the γ- and β-globin genes, promoting globin gene switching. It interacts with GATA-1, a major erythroid transcription factor, and enhances its binding to different regulatory regions across the β-globin gene locus. Ikaros has been associated with γ-globin gene silencing.

Synonyms: K1 , LYF1 , LyF-1 , CVID13 , IKAROS , PPP1R92 , PRO0758 , ZNFN1A1 , Hs.54452


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Publications / Origin

  1. Dijon M, Bardin F, Murati A, Batoz M, Chabannon C, Tonnelle C, The role of Ikaros in human erythroid differentiation., Blood, 111(3), 1138-46, 2008 PubMed
  2. Bottardi S, Ross J, Bourgoin V, Fotouhi-Ardakani N, Affar el B, Trudel M, Milot E, Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes., Mol. Cell. Biol., 29(6), 1526-37, 2009 PubMed
Created on 2020-03-27 19:13:39, Last reviewed on 2020-03-27 19:14:34 (Show full history)

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