GeneID: 371


Common Name: Mi-2β Type: Gene
Chromosome: 12 (NC_000012.12) Locus: NG_052823.1 (CHD4)
HUGO Symbol: CHD4 Full Name: chromodomain helicase DNA binding protein 4
Exons: 40 Introns: 39

This gene encodes a member of the CHD family of proteins (ATP-dependent chromatin remodelers) which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD4 is a key component of NuRD, a protein complex that comprises both nucleosome remodeling and deacetylase activities. The NuRD complex has been associated with epigenetic mechanisms of transcriptional repression during development, and has been shown to play an important role in globin regulation. Κnockdown of the CHD4 protein led to an increase in embryonic and fetal globin gene expression in human adult erythroid cells. The effect of CHD4 on γ-globin gene silencing appears to be mediated both through the MBD2-NuRD repressor complex and through positive regulation of the KLF1 and BCL11A genes.

Synonyms: CHD-4 , Mi-2b , SIHIWES , Mi2-BETA


Sequence Viewer

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Publications / Origin

  1. Thein SL, Genetic association studies in β-hemoglobinopathies., Hematology Am Soc Hematol Educ Program, 2013(0), 354-61, 2013 PubMed
  2. Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC, Ginder GD, Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells., Blood, 121(17), 3493-501, 2013 PubMed
  3. Hoffmeister H, Fuchs A, Erdel F, Pinz S, Gröbner-Ferreira R, Bruckmann A, Deutzmann R, Schwartz U, Maldonado R, Huber C, Dendorfer AS, Rippe K, Längst G, CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality., Nucleic Acids Res., 45(18), 10534-10554, 2017 PubMed
Created on 2020-03-27 17:58:37, Last reviewed on (Show full history)

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