GeneID: 369


Common Name: MBD2 Type: Gene
Chromosome: 18 (NC_000018.10) Locus: NG_029550.1 (MBD2)
HUGO Symbol: MBD2 Full Name: methyl-CpG binding domain protein 2
Exons: 7 Introns: 6

Methyl-CpG binding domain (MBD) protein 2 (MBD2) belongs to the methyl-CpG-binding protein (MCBP2) family. Members of this family share approximately 70 amino acid domains that selectively recognize methylated cytosine-guanosine dinucleotides (mCpGs). DNA methylation-mediated transcriptional repression is thought to be due to the recruitment of MCBPs and repressive protein complexes to methylated DNA. MBD2 is part of the Nucleosome Remodeling and Deacetylase (NuRD) complex, one of the major regulators of chromatin structure and transcription. The C-terminal coiled-coil domain of MBD2 binds a GATAD2 protein, thereby linking the histone deacetylase core subcomplex (HDCC; comprising the MTA, HDAC, and RBBP proteins) of NuRD with the CHD proteins (ATP-dependent chromatin remodelers). The NuRD complex plays an important role in globin regulation. Disruption of MBD2-NuRD in mouse models of human β-globin gene regulation as well as primary human cells and cell lines leads to an increase in the expression of fetal haemoglobin.

Synonyms: DMTase , NY-CO-41


Sequence Viewer

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Publications / Origin

  1. Rupon JW, Wang SZ, Gaensler K, Lloyd J, Ginder GD, Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice., Proc. Natl. Acad. Sci. U.S.A., 103(17), 6617-22, 2006 PubMed
  2. Leighton G, Williams DC, The Methyl-CpG-Binding Domain 2 and 3 Proteins and Formation of the Nucleosome Remodeling and Deacetylase Complex., J. Mol. Biol., 2019 PubMed
Created on 2020-03-27 17:02:28, Last reviewed on 2020-03-27 17:04:34 (Show full history)

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