GeneID: 357

Names

Common Name:	NAT1	Type:	Gene
Chromosome:	8 (NC_000008.11)	Locus:	NG_012245.2 (NAT1)
HUGO Symbol:	NAT1	Full Name:	N-acetyltransferase 1
Exons:	4	Introns:	3

Description:
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Genetic variance in NAT1 gene associated with episodes of pain in patients with sickle cell disease.

Synonyms: AAC1 , MNAT , NATI , NAT-1

Comments:
N/A

Number of entries/variants: 0

External Links

NCBI Gene	UniProtKB
PDB	HGNC
OMIM

IthaScore

Sequence Viewer

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Publications / Origin

Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed

Created on 2020-01-23 14:41:14, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2020-01-23 14:41:14	The IthaGenes Curation Team	Created

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