GeneID: 355



Names

Common Name: IKZF4 Type: Gene
Chromosome: 12 (NC_000012.12) Locus: NM_022465.4 (IKZF4)
HUGO Symbol: IKZF4 Full Name: IKAROS family zinc finger 4
Exons: 8 Introns: 7

Description:
The protein encoded by this gene belongs to the Ikaros (ZNFN1A1) family of transcription factors, which also includes Aiolos (IKZF3) and Helios (IKZF2). IKZF4 binds to the WGGGAAT Ikaros recognition site and functions as a transcriptional repressor. It interacts with FOXP3 and mediates FOXP3-dependent gene silencing in regulatory T-cells via recruitment of co-repressor CTBP1. It decreases the interaction between the β-globin locus control region (LCR) and the promoter regions of γ-globin genes via recruitment of chromatin modifying and remodeling proteins, including HDAC1 and Mi-2. IKZF4 is a key player in the transcriptional regulation of the γ-globin gene during erythroid differentiation.

Synonyms: Eos , ZNFN1A4

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Pan F, Yu H, Dang EV, Barbi J, Pan X, Grosso JF, Jinasena D, Sharma SM, McCadden EM, Getnet D, Drake CG, Liu JO, Ostrowski MC, Pardoll DM, Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells., Science, 325(5944), 1142-6, 2009 PubMed
  2. Bottardi S, Ross J, Bourgoin V, Fotouhi-Ardakani N, Affar el B, Trudel M, Milot E, Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes., Mol. Cell. Biol., 29(6), 1526-37, 2009 PubMed
  3. Yu HC, Zhao HL, Wu ZK, Zhang JW, Eos negatively regulates human γ-globin gene transcription during erythroid differentiation., PLoS ONE, 6(7), e22907, 2011 PubMed
Created on 2020-01-13 23:44:10, Last reviewed on 2020-01-13 23:46:58 (Show full history)


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