GeneID: 349


Common Name: FOP Type: Gene
Chromosome: 1 (NC_000001.11) Locus: NG_030030.1 (CHTOP)
HUGO Symbol: CHTOP Full Name: chromatin target of PRMT1
Exons: 6 Introns: 5

This gene encodes a small nuclear protein that is characterized by a central arginine- and glycine-rich domain similar to that found in nucleolin and fibrillarin. The encoded protein may be involved in cell cycle progression and plays a role in the activation of estradiol-dependent transcription. It is a target of methylation by the PRMT1 and PRMT5 arginine methyltransferases, which are thought to regulate globin expression via histone modifications. Knockdown of FOP resulted in increased γ-globin gene expression in cultured primary human erythroid cells, suggesting that FOP is a critical modulator of fetal globin expression.

Synonyms: SRAG , SRAG-3 , SRAG-5 , pp7704 , C1orf77 , FL-SRAG , C10orf77


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Publications / Origin

  1. van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S, Fetal globin expression is regulated by Friend of Prmt1., Blood, 116(20), 4349-52, 2010 PubMed
  2. van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S, Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases., Mol. Cell. Biol., 30(1), 260-72, 2010 PubMed
Created on 2020-01-10 10:32:53, Last reviewed on 2020-03-27 11:56:10 (Show full history)

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