GeneID: 349

Description:
This gene encodes a small nuclear protein that is characterized by a central arginine- and glycine-rich domain similar to that found in nucleolin and fibrillarin. The encoded protein may be involved in cell cycle progression and plays a role in the activation of estradiol-dependent transcription. It is a target of methylation by the PRMT1 and PRMT5 arginine methyltransferases, which are thought to regulate globin expression via histone modifications. Knockdown of FOP resulted in increased γ-globin gene expression in cultured primary human erythroid cells, suggesting that FOP is a critical modulator of fetal globin expression.

Synonyms: SRAG , SRAG-3 , SRAG-5 , pp7704 , C1orf77 , FL-SRAG , C10orf77

Comments:
N/A

Number of entries/variants: 0

1. van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S, Fetal globin expression is regulated by Friend of Prmt1., Blood, 116(20), 4349-52, 2010 PubMed
2. van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S, Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases., Mol. Cell. Biol., 30(1), 260-72, 2010 PubMed