GeneID: 347



Names

Common Name: LIN28B Type: Gene
Chromosome: 6 (NC_000006.12) Locus: NG_032815.1 (LIN28B)
HUGO Symbol: LIN28B Full Name: lin-28 homolog B
Exons: 4 Introns: 3

Description:
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of retroviral-type CCHC zinc finger domains. It is highly expressed in the testis, fetal liver, and placenta. LIN28B binds and inhibits let-7 miRNAs, which function as important regulators of fetal-to-adult developmental transition in erythroid tissues. Overexpression of LIN28B proteins or decreased expression of its target let-7 miRNAs enhanced fetal haemoglobin (HbF) levels in adult erythroid cells and ameliorated the hypoxia-related sickling of cultured erythroblasts. Independently of its role in regulating let-7 microRNAs, LIN28B directly interacts with and suppresses BCL11A, a key regulator of developmental haemoglobin switching and silencing of HbF in adults. LIN28B is a candidate regulator of HbF expression.

Synonyms: CSDD2

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Lee YT, de Vasconcellos JF, Yuan J, Byrnes C, Noh SJ, Meier ER, Kim KS, Rabel A, Kaushal M, Muljo SA, Miller JL, LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo., Blood, 122(6), 1034-41, 2013 PubMed
  2. de Vasconcellos JF, Fasano RM, Lee YT, Kaushal M, Byrnes C, Meier ER, Anderson M, Rabel A, Braylan R, Stroncek DF, Miller JL, LIN28A expression reduces sickling of cultured human erythrocytes., PLoS ONE, 9(9), e106924, 2014 PubMed
  3. Basak A, Munschauer M, Lareau CA, Montbleau KE, Ulirsch JC, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, Mohandas N, Carr SA, Chen JJ, Orkin SH, Lander ES, Sankaran VG, Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation., Nat. Genet., 2020 PubMed
Created on 2020-01-09 12:35:14, Last reviewed on 2020-01-23 09:52:02 (Show full history)


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