GeneID: 34



Names

Common Name: ARG2 Type: Gene
Chromosome: 14 (NC_000014.9) Locus: NG_011964.1 (ARG2)
HUGO Symbol: ARG2 Full Name: arginase 2
Exons: 8 Introns: 7

Description:
Arginase catalyses the hydrolysis of arginine to ornithine and urea. The type II isoform encoded by this gene is located in the mitochondria and expressed in extra-hepatic tissues, especially the kidney. The physiological role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. Polymorphisms in the ARG2 gene associated with the HbF response to hydroxyurea (HU) in sickle cell patients.

Synonyms: arginase, type II

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Vockley JG, Jenkinson CP, Shukla H, Kern RM, Grody WW, Cederbaum SD, Cloning and characterization of the human type II arginase gene., Genomics , 38(2), 118-23, 1996 PubMed
  2. Iyer R, Jenkinson CP, Vockley JG, Kern RM, Grody WW, Cederbaum S, The human arginases and arginase deficiency., J. Inherit. Metab. Dis. , 21(0), 86-100, 1998 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-05-25 16:00:19 (Show full history)


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