GeneID: 335


Common Name: MCM6 Type: Gene
Chromosome: 2 (NC_000002.12) Locus: NG_008958.1 (MCM6)
HUGO Symbol: MCM6 Full Name: N/A
Exons: 17 Introns: 16

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. MCM6 is one of the proteins (MCM2-7) that play a role in 'licensing' the replication of DNA and are thought to bind to DNA after mitosis (G1) and to be removed from the DNA during replication (S phase). Low levels of MCM6 are linked with replication stress and functional deterioration of haematopoietic stem cells. Genetic variance in MCM6 gene associated with haematological parameters (e.g., white blood cell count).

Synonyms: Mis5 , P105MCM , MCG40308


Sequence Viewer

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Publications / Origin

  1. Harvey CB, Wang Y, Darmoul D, Phillips A, Mantei N, Swallow DM, Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21., FEBS Lett., 398(2), 135-40, 1996 PubMed
  2. Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Méndez J, Morrison CG, Passegué E, Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells., Nature, 512(7513), 198-202, 2014 PubMed
  3. Kim YK, Oh JH, Kim YJ, Hwang MY, Moon S, Low SK, Takahashi A, Matsuda K, Kubo M, Lee J, Kim BJ, Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach., Biomed Res Int , 2015(0), 914965, 2015 PubMed
Created on 2019-12-10 09:17:14, Last reviewed on (Show full history)

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