GeneID: 316


Common Name: CYP3A4 Type: Gene
Chromosome: 7 (NC_000007.14) Locus: NG_008421.1 (CYP3A4)
HUGO Symbol: CYP3A4 Full Name: cytochrome P450 family 3 subfamily A member 4
Exons: 13 Introns: 12

CYP3A4 is a member of the cytochrome P450 (CYP) superfamily of monooxygenases that catalyze the metabolism of various endogenous and exogenous substrates, including xenobiotics, steroids, and fatty acids. CYP3A4 is the most abundant enzyme of CYPs in the liver, metabolizing more than 50% of the clinically used drugs. Genetic variance in CYP3A4 gene associated with episodes of pain in patients with sickle cell disease.

Synonyms: CYP3A , NF-25 , CYP3A3 , P450C3 , CYPIIIA3 , CYPIIIA4


Sequence Viewer

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Publications / Origin

  1. Zhou SF, Xue CC, Yu XQ, Li C, Wang G, Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring., Ther Drug Monit, 29(6), 687-710, 2007 PubMed
  2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
Created on 2019-11-27 12:33:57, Last reviewed on (Show full history)

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