GeneID: 314


Common Name: MTNR1A Type: Gene
Chromosome: 4 (NC_000004.12) Locus: NM_005958.4 (MTNR1A)
HUGO Symbol: MTNR1A Full Name: melatonin receptor 1A
Exons: 2 Introns: 1

This gene encodes one of two high affinity forms of a receptor for melatonin, a neurohormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for the circadian and reproductive effects of melatonin. The circadian effects of melatonin appear to be mediated by melatonin receptors in the hypothalamic suprachiasmatic nucleus, the site of a circadian clock. The reproductive effects of melatonin may be mediated by receptors in the hypophyseal pars tuberalis. Chronic pain syndromes are associated with various degrees of biological rhythm desynchronization, which are controlled by the suprachiasmatic nuclei of the hypothalamus. Many studies have demonstrated melatonin efficacy in relation to nociceptive and neuropathic pain. Genetic variance in MTNR1A gene associated with episodes of pain in patients with sickle cell disease.

Synonyms: MT1 , MEL-1A-R


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Publications / Origin

  1. Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM, Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)., Genomics, 27(2), 355-7, 1995 PubMed
  2. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
  3. Danilov A, Kurganova J, Melatonin in Chronic Pain Syndromes., Pain Ther, 5(1), 1-17, 2016 PubMed
Created on 2019-11-26 17:00:31, Last reviewed on (Show full history)

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