GeneID: 294



Names

Common Name: GPR17 Type: Gene
Chromosome: 2 (NC_000002.12) Locus: NM_001161415.1 (GPR17)
HUGO Symbol: GPR17 Full Name: G protein-coupled receptor 17
Exons: 4 Introns: 3

Description:
The encoded protein is a member of the G protein-coupled receptor (GPCR) superfamily. GPCRs consist of 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The GPR17 receptor responds to both uracil nucleotides (e.g., UDP-glucose) and cysteinyl-leukotrienes (CysLTs; e.g., LTD4). Functional studies suggested that GPR17 acts as a mediator of the inflammatory effects induced by nucleotides and CysLTs. Variations in this gene associated with acute chest syndrome (ACS) in patients with sickle cell disease. ACS is a form of acute lung injury caused by vaso-occlusion within the pulmonary microvasculature. Etiologies either trigger vaso-occlusion (e.g., infection, asthma, hypoventilation) or are a result of vaso-occlusion (e.g., bone marrow and fat emboli).

Synonyms: N/A

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, Ferrario S, Parravicini C, Capra V, Gelosa P, Guerrini U, Belcredito S, Cimino M, Sironi L, Tremoli E, Rovati GE, Martini C, Abbracchio MP, The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor., EMBO J., 25(19), 4615-27, 2006 PubMed
  2. Melton CW, Haynes J, Sickle acute lung injury: role of prevention and early aggressive intervention strategies on outcome., Clin. Chest Med., 27(3), 487-502, vii, 2006 PubMed
  3. Daniele S, Trincavelli ML, Gabelloni P, Lecca D, Rosa P, Abbracchio MP, Martini C, Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands., J. Pharmacol. Exp. Ther., 338(2), 559-67, 2011 PubMed
  4. Galarneau G, Coady S, Garrett ME, Jeffries N, Puggal M, Paltoo D, Soldano K, Guasch A, Ashley-Koch AE, Telen MJ, Kutlar A, Lettre G, Papanicolaou GJ, Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients., Blood , 122(3), 434-42, 2013 PubMed
Created on 2019-10-03 10:18:49, Last reviewed on (Show full history)


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