GeneID: 289


Common Name: LYAR Type: Gene
Chromosome: 4 (NC_000004.12) Locus: NM_017816.3 (LYAR)
HUGO Symbol: LYAR Full Name: Ly1 antibody reactive
Exons: 10 Introns: 9

LYAR (Ly1 antibody reactive) is a zinc-finger transcription factor that binds to the 5'-GGTTAT-3' region of the 5' UTR of the Aγ-globin gene. It directly interacts with and recruits the methyltransferase PRMT5, which induces the repressive epigenetic mark H4R3me2s, in turn silencing γ-globin gene expression. LYAR knockdown leads to reactivation of embryonic β-like globin genes in MEL cells and to reactivation of Hb F in human erythroid cells. The rs368698783 G>A polymorphism resides in the LYAR-binding site of the Aγ-globin gene, attenuating binding of LYAR and its complexes to the target DNA sequence.

Synonyms: ZC2HC2 , ZLYAR


Sequence Viewer

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Publications / Origin

  1. Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L, Zou F, Ma C, Fang M, Tan R, Jane SM, Zhao Q, Human fetal globin gene expression is regulated by LYAR., Nucleic Acids Res., 42(15), 9740-52, 2014 PubMed
  2. Chen D, Zuo Y, Zhang X, Ye Y, Bao X, Huang H, Tepakhan W, Wang L, Ju J, Chen G, Zheng M, Liu D, Huang S, Zong L, Li C, Chen Y, Zheng C, Shi L, Zhao Q, Wu Q, Fucharoen S, Zhao C, Xu X, A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression., Am. J. Hum. Genet. , 101(1), 130-138, 2017 PubMed
  3. Gemmo C, Breveglieri G, Marzaro G, Lampronti I, Cosenza LC, Gasparello J, Zuccato C, Fabbri E, Borgatti M, Chilin A, Finotti A, Gambari R, Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia., Anal Bioanal Chem, 2019 PubMed
Created on 2019-09-30 14:56:05, Last reviewed on (Show full history)

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