GeneID: 287

Names

Common Name:	SULT2B1	Type:	Gene
Chromosome:	19 (NC_000019.10)	Locus:	NG_029063.1 (SULT2B1)
HUGO Symbol:	SULT2B1	Full Name:	sulfotransferase family 2B member 1
Exons:	7	Introns:	6

Description:
The human hydroxysteroid sulfotransferase (SULT) 2B1 gene, a member of the cytosolic SULT gene superfamily, encodes 2 isoforms, SULT2B1a and SULT2B1b. SULT2B1b catalyzes the sulfonation of 3-beta hydroxysteroid hormones and cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation. The SULT2B1 gene associated with diastolic dysfunction in patients with sickle cell disease (SCD) in spite of conflicting evidence in a pre-clinical SCD mouse model.

Synonyms: HSST2 , ARCI14

Comments:
N/A

Number of entries/variants: 0

External Links

NCBI Gene	UniProtKB
PDB	HGNC
OMIM

IthaScore

Sequence Viewer

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Publications / Origin

Ji Y, Moon I, Zlatkovic J, Salavaggione OE, Thomae BA, Eckloff BW, Wieben ED, Schaid DJ, Weinshilboum RM, Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics., J. Pharmacol. Exp. Ther., 322(2), 529-40, 2007 PubMed
Duarte JD, Desai AA, Sysol JR, Abbasi T, Patel AR, Lang RM, Gupta A, Garcia JG, Gordeuk VR, Machado RF, Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease., PLoS ONE , 11(9), e0163013, 2016 PubMed

Created on 2019-09-30 14:21:45, Last reviewed on (Show full history)

A/A	Date	Curator(s)	Comments
1	2019-09-30 14:21:45	The IthaGenes Curation Team	Created

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