GeneID: 273



Names

Common Name: COPE Type: Gene
Chromosome: 19 (NC_000019.10) Locus: NM_001330469.2 (COPE)
HUGO Symbol: COPE Full Name: coatomer protein complex subunit epsilon
Exons: 11 Introns: 10

Description:
The COPE gene encodes coatomer protein complex subunit epsilon, one of seven subunits (α, β, β', γ, δ, ε, ζ) comprising the coat protein complex I (COPI). COPI coats vesicles and mediates transport between the Golgi complex and endoplasmic reticulum. A variation in COPE associated with Hb F response to hydroxyurea (HU) in sickle cell disease cohorts. Components of the coat protein complex II (COPII) have been previously implicated in the regulation of γ-globin expression after HU treatment [see GeneID: 84 and 272].

Synonyms: epsilon-COP

Comments:
N/A

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Publications / Origin

  1. Hsu VW, Yang JS, Mechanisms of COPI vesicle formation., FEBS Lett., 583(23), 3758-63, 2009 PubMed
  2. Sheehan VA, Crosby JR, Sabo A, Mortier NA, Howard TA, Muzny DM, Dugan-Perez S, Aygun B, Nottage KA, Boerwinkle E, Gibbs RA, Ware RE, Flanagan JM, Whole exome sequencing identifies novel genes for fetal hemoglobin response to hydroxyurea in children with sickle cell anemia., PLoS ONE , 9(10), e110740, 2014 PubMed
Created on 2019-09-24 16:23:09, Last reviewed on (Show full history)


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