GeneID: 26


Common Name: EIF2S3 Type: Gene
Chromosome: X (NC_000023.11) Locus: NG_016387.1 (EIF2S3)
HUGO Symbol: EIF2S3 Full Name: eukaryotic translation initiation factor 2 subunit gamma
Exons: 12 Introns: 11

eIF-2 is a translation initiation factor that functions in the early steps of protein synthesis by forming a ternary complex with GTP and the initiator tRNA Met-tRNAi. This complex binds to the 40S ribosomal subunit, followed by binding of the mRNA to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyse another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzsed by eIF-2B. Polymorphisms in this gene associated with HbF levels in sickle cell patients.

Synonyms: EIF2G , EIF2 , EIF2gamma , eukaryotic translation initiation factor 2G


Sequence Viewer

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Publications / Origin

  1. Gaspar NJ, Kinzy TG, Scherer BJ, Hümbelin M, Hershey JW, Merrick WC, Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit., J. Biol. Chem. , 269(5), 3415-22, 1994 PubMed
  2. Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM, Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution., Hum. Mol. Genet. , 7(11), 1725-37, 1998 PubMed
  3. Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis DA, Klings ES, Farrer LA, Garrett ME, Ashley-Koch A, Telen MJ, Fucharoen S, Ha SY, Li CK, Chui DH, Baldwin CT, Steinberg MH, Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster., Blood , 115(9), 1815-22, 2010 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 13:30:04 (Show full history)

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