GeneID: 257



Names

Common Name: TRPV1 Type: Gene
Chromosome: 17 (NC_000017.11) Locus: NG_029716.1 (TRPV1)
HUGO Symbol: TRPV1 Full Name: transient receptor potential cation channel subfamily V member 1
Exons: 17 Introns: 16

Description:
TRPV1 is a member of the transient receptor potential (TRP) family of ion channels that act as sensors of a wide range of cellular and environmental signals, mediating pain sensitivity. There are seven TRP protein sub-families; TRPV (vanilloid), TRPC (canonical), TRPM (melastatin), TRPML (mucolipin), TRPA (ankyrin), TRPP (polycystin), and TRPN (NOMPC-like; only in invertebrates and fish). TRP channels contain six-transmembrane polypeptide subunits forming tetramers with a central ion conducting pore. TRPV1 is a polymodal receptor activated by diverse sensory processes, including the vanilloid compound capsaicin (the pungent ingredient of 'hot' chili peppers), animal toxins (e.g., RhTx in centipede venom), noxious heat (>42 °C), extracellular protons, and inflammatory agents (e.g., bradykinin, serotonin, histamine, or prostaglandins). TRPV1 activity can be modulated by protein kinase-dependent phosphorylation (e.g., protein kinase A, protein kinase C, calcium calmodulin–dependent kinase II (CaMKII), or Src kinase). TRPV1 is a non-selective cation channel expressed predominantly in the primary sensory neurons (nociceptors) and also different regions of the brain. Activation of TRPV1 triggers an influx of sodium and calcium ions that results in the depolarization of the cellular membrane, neuronal firing and finally the sensation of pain. TRPV1 plays a major role in the generation and/or maintenance of inflammatory and neuropathic pain. Chemical inhibition of TRPV1 attenuated nociceptor sensitization in a sickle cell disease (SCD) mouse model. No study has yet replicated the association of genetic variants of TRPV1 with pain in human cohorts of SCD.

Synonyms: VR1

Comments:
N/A

Sequence Viewer

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Publications / Origin

  1. Hayes P, Meadows HJ, Gunthorpe MJ, Harries MH, Duckworth DM, Cairns W, Harrison DC, Clarke CE, Ellington K, Prinjha RK, Barton AJ, Medhurst AD, Smith GD, Topp S, Murdock P, Sanger GJ, Terrett J, Jenkins O, Benham CD, Randall AD, Gloger IS, Davis JB, Cloning and functional expression of a human orthologue of rat vanilloid receptor-1., Pain, 88(2), 205-15, 2000 PubMed
  2. Nilius B, Owsianik G, The transient receptor potential family of ion channels., Genome Biol., 12(3), 218, 2011 PubMed
  3. Hillery CA, Kerstein PC, Vilceanu D, Barabas ME, Retherford D, Brandow AM, Wandersee NJ, Stucky CL, Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease., Blood, 118(12), 3376-83, 2011 PubMed
  4. Brito R, Sheth S, Mukherjea D, Rybak LP, Ramkumar V, TRPV1: A Potential Drug Target for Treating Various Diseases., Cells, 3(2), 517-45, 2014 PubMed
  5. Yang F, Zheng J, Understand spiciness: mechanism of TRPV1 channel activation by capsaicin., Protein Cell, 8(3), 169-177, 2017 PubMed
  6. Jhun EH, Hu X, Sadhu N, Yao Y, He Y, Wilkie DJ, Molokie RE, Wang ZJ, Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease., Pharmacogenomics, 19(5), 401-411, 2018 PubMed
Created on 2019-03-19 12:07:55, Last reviewed on (Show full history)


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