GeneID: 255
Names
Common Name: | CERS4 | Type: | Gene |
---|---|---|---|
Chromosome: | 19 (NC_000019.10) | Locus: | N/A |
HUGO Symbol: | CERS4 | Full Name: | ceramide synthase 4 |
Exons: | 12 | Introns: | 11 |
Description:
The CERS4 gene encodes the enzyme ceramide synthase, which is involved in the de novo synthesis of ceramides. Ceramides are lipid molecules composed of sphingosine with a fatty acid, and are found in the cell membrane. Ceramide plays an important role as a modulator of membrane structure, also contributing to a variety of cellular signalling events, including proliferation, differentiation and programmed cell death. CERS4 is a member of a family of six ceramide synthases (CERS), each of which synthesizes ceramides with distinct acyl chain lengths. CERS catalyze the formation of an amide linkage between a fatty acyl-CoA and a sphingoid long chain base. CERS4 uses fatty acyl-CoA substrates of chain lengths from C18 to C20. The CERS4 gene is expressed at low levels in all tissues, but more prominently in skin, leukocytes, heart and liver. A CERS4 variant associated with leukocytosis in sickle cell anaemia.
Synonyms: Trh1 , LASS4
Comments:
N/A
Number of entries/variants: 1
IthaScore
Sequence Viewer
Publications / Origin
A/A | Date | Curator(s) | Comments |
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1 | 2019-03-19 11:55:29 | The IthaGenes Curation Team | Created |