GeneID: 25



Names

Common Name: DHRS7C-GLP2R Type: Intergenic Region
Chromosome: 17 (NC_000017.11) Locus: NT_010718.16 (DHRS7C-GLP2R)
HUGO Symbol: DHRS7C-GLP2R Full Name: N/A
Exons: N/A Introns: N/A

Description:
DHRS7C is a member of the Short-Chain Dehydrogenase/Reductase and Related Enzymes (SDR), which are involved in the metabolism of a large variety of compounds, including steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. In humans, over 70 SDR genes have been identified. The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor and GLP1 receptor. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and is closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). Polymorphisms in this intergenic region (DHRS7C-GLP2R) associated with F-cell levels in sickle cell patients.

Synonyms: N/A

Comments:
N/A

External Links

No available links

Sequence Viewer

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Publications / Origin

  1. Munroe DG, Gupta AK, Kooshesh F, Vyas TB, Rizkalla G, Wang H, Demchyshyn L, Yang ZJ, Kamboj RK, Chen H, McCallum K, Sumner-Smith M, Drucker DJ, Crivici A, Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2., Proc. Natl. Acad. Sci. U.S.A. , 96(4), 1569-73, 1999 PubMed
  2. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U, The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative., Chem. Biol. Interact. , 178(1), 94-8, 2009 PubMed
  3. Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR, Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients., J. Hum. Genet. , 56(4), 316-23, 2011 PubMed
Created on 2014-04-01 14:19:10, Last reviewed on 2016-04-28 13:21:09 (Show full history)


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