GeneID: 245



Names

Common Name: ZBTB7A Type: Gene
Chromosome: 19 (NC_000019.10) Locus: N/A
HUGO Symbol: ZBTB7A Full Name: zinc finger and BTB domain containing 7A
Exons: 3 Introns: 2

Description:
The ZBTB7A gene encodes LRF (lymphoma/leukemia-related factor), a member of the BTB/POZ and Krüppel (POK) family of transcription factors. This family of proteins is characterized by one or more C-terminal C2H2/Krüppel-type zinc finger DNA-binding domains and an N-terminal BTB/POZ domain that tethers transcriptional repressor complexes. The POK transcription factors are crucial regulators of haematopoietic lineage commitment and differentiation, and have been implicated in tumorigenesis. ZBTB7A/LRF plays a crucial role in B-cell lineage commitment and functions as a tumour suppressor by transcriptionally repressing glycolytic and oncogenic pathways. Moreover, ZBTB7A/LRF has emerged as a crucial regulator of γ-globin gene expression in erythroid cells. It is a KLF1 target gene associated with HbF repression, and thus a promising target for therapeutic induction of HbF levels in patients with β-globinopathies.

Synonyms: LRF , pokemon , FBI1 , FBI-1 , TIP21 , ZBTB7 , ZNF857A

Comments:
N/A

Sequence Viewer

Note: The NCBI Sequence Viewer is not installed on the ITHANET servers but it is embedded in this page from the NCBI. Therefore, IthaGenes has no responsibility over any temporary unavailability of the service. In such a case, please Refresh the page or retry at a later stage.

Publications / Origin

  1. Lee SU, Maeda T, POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function., Immunol. Rev. , 247(1), 107-19, 2012 PubMed
  2. Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM, ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis., Genes Dev. , 28(17), 1917-28, 2014 PubMed
  3. Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP, LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair., Nat Commun , 6(0), 8325, 2015 PubMed
  4. Norton LJ, Funnell APW, Burdach J, Wienert B, Kurita R, Nakamura Y, Philipsen S, Pearson RCM, Quinlan KGR, Crossley M, KLF1 directly activates expression of the novel fetal globin repressor in erythroid cells., Blood Adv , 1(11), 685-692, 2017 PubMed
  5. Zhu C, Chen G, Zhao Y, Gao XM, Wang J, Regulation of the Development and Function of B Cells by ZBTB Transcription Factors., Front Immunol , 9(0), 580, 2018 PubMed
  6. Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M, Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding., Nat. Genet. , 50(4), 498-503, 2018 PubMed
Created on 2018-06-19 19:04:35, Last reviewed on (Show full history)


Disclaimer: The information on this website is provided as an information resource only and must not to be used as a substitute for professional diagnosis and treatment. The ITHANET Portal and IthaGenes are not responsible or liable for any advice, course of treatment, diagnosis or any other information, services or products that an individual obtains through this website.

Please publish modules in offcanvas position.